Browsing by Author "Vrijheid, Martine"

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  • Cord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
    Alfano, Rossella; Zugna, Daniela; Barros, Henrique; Bustamante Pineda, Mariona; Chatzi, Leda; Ghantous, Akram; Herceg, Zdenko; Keski-Rahkonen, Pekka; Kok, Theo M. de; Nawrot, Tim S.; Relton, Caroline L.; Robinson, Oliver; Roumeliotaki, Theano; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Plusquin, Michelle (BioMed Central, 2023)
    Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interfacing ...
  • Cord blood metabolic signatures predictive of childhood overweight and rapid growth
    Handakas, Evangelos; Keski-Rahkonen, Pekka; Chatzi, Leda; Alfano, Rossella; Roumeliotaki, Theano; Plusquin, Michelle; Maitre, Léa; Richiardi, Lorenzo; Brescianini, Sonia; Scalbert, Augustin; Robinot, Nivonirina; Nawrot, Tim S.; Sassi, Franco; Vrijheid, Martine; Vineis, Paolo; Robinson, Oliver (Nature Research, 2021)
    Introduction: Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy ...
  • Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
    Alfano, Rossella; Plusquin, Michelle; Robinson, Oliver; Brescianini, Sonia; Chatzi, Leda; Keski-Rahkonen, Pekka; Handakas, Evangelos; Maitre, Léa; Nawrot, Tim S.; Robinot, Nivonirina; Roumeliotaki, Theano; Sassi, Franco; Scalbert, Augustin; Vrijheid, Martine; Vineis, Paolo; Richiardi, Lorenzo; Zugna, Daniela (Nature Research, 2022)
    Background: The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight ...
  • Determinants of the urinary and serum metabolome in children from six European populations
    Lau, Chung-Ho E.; Maitre, Léa; Urquiza, José M.; Casas Sanahuja, Maribel; Vrijheid, Martine; Coen, Muireann (BioMed Central, 2018)
    Background: Environment and diet in early life can affect development and health throughout the life course. Metabolic phenotyping of urine and serum represents a complementary systems-wide approach to elucidate ...
  • Diet as a source of exposure to environmental contaminants for pregnant women and children from six european countries
    Papadopoulou, Eleni, 1985-; Haug, Line Småstuen; Sakhi, Amrit Kaur; Andrušaitytė, Sandra; Basagaña Flores, Xavier; Brantsaeter, Anne Lise; Casas Sanahuja, Maribel; Fernández Barrés, Sílvia; Grazuleviciene, Regina; Knutsen, Helle Katrine; Maitre, Léa; Meltzer, Helle Margrete; McEachan, Rosemary R.C.; Roumeliotaki, Theano; Slama, Rémy; Vafeiadi, Marina, 1983-; Wright, John; Vrijheid, Martine; Thomsen, Cathrine; Chatzi, Leda (National Institute of Environmental Health Sciences, 2019)
    Background: Pregnant women and children are especially vulnerable to exposures to food contaminants, and a balanced diet during these periods is critical for optimal nutritional status. Objectives: Our objective was to ...
  • Dietary inflammatory index of mothers during pregnancy and Attention Deficit-Hyperactivity Disorder symptoms in the child at preschool age: a prospective investigation in the INMA and RHEA cohorts
    Lertxundi, Nerea; Molinuevo, Amaia; Valvi, Dania; Gorostiaga, Arantxa; Balluerka, Nekane; Shivappa, Nitin; Hebert, James R.; Navarrete-Muñoz, Eva-María; Vioque, Jesus; Tardón, Adonina; Vrijheid, Martine; Roumeliotaki, Theano; Koutra, Katerina; Chatzi, Leda; Ibarluzea, Jesús (Elsevier, 2022)
    Inflammation provides a substrate for mechanisms that underlie the association of maternal diet during pregnancy with Attention Deficit-Hyperactivity Disorder (ADHD) symptoms in childhood. However, no previous study has ...
  • DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
    Vehmeijer, Florianne O. L.; Salas Díaz, Lucas Andrés, 1980-; Ruiz Arenas, Carlos, 1990-; Vrijheid, Martine; Bustamante Pineda, Mariona; Felix, Janine Frédérique (BioMed Central, 2020)
    Background: DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely ...
  • DNA methylation changes associated with prenatal mercury exposure: A meta-analysis of prospective cohort studies from PACE consortium
    Lozano, Manuel; Vrijheid, Martine; Bustamante Pineda, Mariona; Llop, Sabrina (Elsevier, 2022)
    Mercury (Hg) is a ubiquitous heavy metal that originates from both natural and anthropogenic sources and is transformed in the environment to its most toxicant form, methylmercury (MeHg). Recent studies suggest that MeHg ...
  • DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
    Joubert, Bonnie R.; Salas Díaz, Lucas Andrés, 1980-; Ruiz, Carlos; Bustamante Pineda, Mariona; Gonzalez, Juan Ramon; Pinart, Mariona; Guerra, Stefano; Vrijheid, Martine; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; London, Stephanie J. (Elsevier, 2016)
    Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child ...
  • DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
    van Dongen, Jenny; Alemany, Silvia; González Ruiz, Juan Ramón; Sunyer Deu, Jordi; Vrijheid, Martine; Boomsma, Dorret I. (Nature Research, 2021)
    DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of genetic, stochastic, and environmental influences associated with aggression. Here, we report the first large meta-analysis of ...
  • Drinking water disinfection by-products during pregnancy and child neuropsychological development in the INMA Spanish cohort study
    Villanueva, Cristina M.; Gracia Lavedan, Esther; Julvez, Jordi; Santa Marina, Loreto; Lertxundi, Nerea; Ibarluzea, Jesús; Llop, Sabrina; Ballester Díez, Ferran; Fernández Somoano, Ana; Tardón, Adonina; Vrijheid, Martine; Guxens Junyent, Mònica; Sunyer Deu, Jordi (Elsevier, 2018)
    Background: Disinfection by-products (DBPs) constitute a complex mixture of prevalent chemicals in drinking water and there is evidence of neurotoxicity for some of them. Objectives: We evaluated the association between ...
  • Early childhood growth is associated with lung function at 7 years: a prospective population-based study
    Peralta, Gabriela P.; Abellan, Alicia; Montazeri, Parisa; Basterrechea, Mikel; Esplugues, Ana; González-Palacios, Sandra; Roda, Célina; Santa Marina, Loreto; Sunyer Deu, Jordi; Vrijheid, Martine; Casas Sanahuja, Maribel; Garcia Aymerich, Judith (European Respiratory Society, 2020)
    Previous studies have related early postnatal growth with later lung function but their interpretation is limited by the methods used to assess a child's growth. We aimed to assess the association of early childhood growth, ...
  • Early life exposure to air pollution, green spaces and built environment, and body mass index growth trajectories during the first 5 years of life: A large longitudinal study
    Bont, Jeroen de; Hughes, Rachael; Tilling, Kate; Díaz, Yesika; de Castro, Montserrat; Cirach, Marta; Fossati, Serena; Nieuwenhuijsen, Mark J.; Duarte Salles, Talita, 1985-; Vrijheid, Martine (Elsevier, 2020)
    Urban environments are characterized by multiple exposures that may influence body mass index (BMI) growth in early life. Previous studies are few, with inconsistent results and no evaluation of simultaneous exposures. ...
  • Early life exposure to perfluoroalkyl substances (PFAS) and ADHD: a meta-nalysis of nine european population-based studies
    Forns i Guzman, Joan, 1981-; Verner, Marc-Andre; Iszatt, Nina; Nowack, Nikola; Bach, Cathrine Carlsen; Vrijheid, Martine; Costa, Olga; Andiarena, Ainara; Sovcikova, Eva; Høyer, Birgit Bjerre; Wittsiepe, Jürgen; López Espinosa, Maria José; Ibarluzea, Jesús; Hertz-Picciotto, Irva; Toft, Gunnar; Stigum, Hein; Guxens Junyent, Mònica; Liew, Zeyan; Eggesbø, Merete (National Institute of Environmental Health Sciences, 2020)
    Introduction: To date, the evidence for an association between perfluoroalkyl substances (PFAS) exposure and attention deficit and hyperactivity disorder (ADHD) is inconclusive. Objective: We investigated the association ...
  • Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries
    Julvez, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Maitre, Léa; Philippat, Claire; Gützkow, Kristine B.; Guxens Junyent, Mònica; Evandt, Jorunn; Andrušaitytė, Sandra; Burgaleta Díaz, Miguel, 1981-; Casas Sanahuja, Maribel; Chatzi, Leda; de Castro, Montserrat; Donaire González, David; Gražulevičienė, Regina; Hernandez-Ferrer, Carles, 1987-; Heude, Barbara; McEachan, Rosie; Mon-Williams, Mark; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sakhi, Amrit Kaur; Sebastián Gallés, Núria; Slama, Rémy; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Thomsen, Cathrine; Urquiza, José M.; Vafeiadi, Marina, 1983-; Basagaña Flores, Xavier; Vrijheid, Martine (Elsevier, 2021)
    Epidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood environmental exposures and cognition. The study ...
  • Early life predictors of child growth trajectories and early adolescent cardiovascular health
    Montazeri, Parisa, 1988- (2021-12-17)
    Research over the previous decades has shown us that early life influences have long-term effects on health and disease. Emerging science supports a role in the pathogenesis of obesity and cardiovascular diseases (CVD) for ...
  • Early-life environmental exposure determinants of child behavior in Europe: A longitudinal, population-based study
    Maitre, Léa; Júlvez Calvo, Jordi; López Vicente, Mònica, 1988-; Warembourg, Charline; Tamayo-Uria, Ibon; Guxens Junyent, Mònica; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; de Castro, Montserrat; Gonzalez, Juan Ramon; Hernandez-Ferrer, Carles, 1987-; Marquez, Sandra; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Vrijheid, Martine (Elsevier, 2021)
    Background: Environmental exposures in early life influence the development of behavioral outcomes in children, but research has not considered multiple exposures. We therefore aimed to investigate the impact of a broad ...
  • Early-life environmental exposures and childhood obesity: an exposome-wide approach
    Vrijheid, Martine; Fossati, Serena; Maitre, Léa; Márquez, Sandra; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Basagaña Flores, Xavier; Chatzi, Leda (National Institute of Environmental Health Sciences, 2020)
    Background: Chemical and nonchemical environmental exposures are increasingly suspected to influence the development of obesity, especially during early life, but studies mostly consider single exposure groups. Objectives: ...
  • Early-life exposome and lung function in children in Europe: an analysis of data from the longitudinal, population-based HELIX cohort
    Agier, Lydiane; Basagaña Flores, Xavier; Maitre, Léa; Casas Sanahuja, Maribel; de Castro, Montserrat; Donaire González, David; Nieuwenhuijsen, Mark J.; Robinson, Oliver; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; Valentín, Antònia; Vrijheid, Martine; Siroux, Valérie (Elsevier, 2019)
    Background: Several single-exposure studies have documented possible effects of environmental factors on lung function, but none has relied on an exposome approach. We aimed to evaluate the association between a broad range ...
  • Efecto del empleo y de la carga doméstica en el desarrollo fetal y en la duración de la gestación en una cohorte de mujeres embarazadas
    Arizo-Luque, Vanessa; García, Ana María; Estarlich, Marisa; Ballester Díez, Ferran; Fernández-Tardón, Guillermo; Tardón, Adonina; Guxens Junyent, Mònica; Vrijheid, Martine; Lertxundi, Aitana; Santa Marina, Loreto; Ronda-Pérez, Elena (Ministerio de Sanidad y Consumo, 2018)
    Fundamentos: Los estudios publicados no son concluyentes sobre el impacto de determinadas exposiciones ocupacionales en el embarazo, evidenciando la necesidad de considerar el doble rol, profesional y familiar, de las ...