Browsing by Author "Vicente García, Rubén, 1978-"

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  • The antigen-binding fragment of human gamma immunoglobulin prevents amyloid β-peptide folding into β-sheet to form oligomers
    Valls Comamala, Victòria, 1987-; Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Puig, Marta; Perálvarez Marín, Alex; Palomer, Ernest; Fernàndez Busquets, Xavier; Altafaj, Xavier; Tajes Orduña, Marta; Puig Pijoan, Albert; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Impact Journals, 2017)
    The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both ...
  • The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism
    Matalonga, Jonathan; Kiefer, Kerstin, 1986-; Vicente García, Rubén, 1978-; Valledor, Annabel F. (Elsevier, 2017)
    Macrophages exert potent effector functions against invading microorganisms but constitute, paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of infection by Salmonella Typhimurium, ...
  • The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways
    Vicente García, Rubén, 1978-; Coma Camprodón, Mireia; Busquets, Silvia; Moore Carrasco, Rodrigo; López Soriano, Francisco J.; Argilés, Josep M.; Felipe, Antonio (Elsevier, 2004)
    TNF-alpha, generated during the systemic inflammatory response, triggers a wide range of biological activities that mediate the neurologic manifestations associated with cancer and infection. Since this cytokine regulates ...
  • Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis
    Martínez-Mármol, Ramón; Comes, Núria; Styrczewska, Katarzyna; Pérez Verdaguer, Mireia; Vicente García, Rubén, 1978-; Pujadas, Lluís; Soriano, Eduardo; Sorkin, Alexander; Felipe, Antonio (Springer, 2016)
    The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and ...
  • Understanding signatures of positive natural selection in human zinc transporter genes
    Roca-Umbert Würth, Ana; Caro Consuegra, Rocio; Londono-Correa, Diego; Rodriguez-Lozano, Gabriel Felipe; Vicente García, Rubén, 1978-; Bosch Fusté, Elena (Nature Research, 2022)
    Zinc is an essential micronutrient with a tightly regulated systemic and cellular homeostasis. In humans, some zinc transporter genes (ZTGs) have been previously reported as candidates for strong geographically restricted ...
  • Validation of ZIP4 as a tumour-associated antigen for nanotargeting
    Xu, Ruixue; Martínez Bosch, Neus; Rivera Hueto, Francisco; Mulens-Arias, Vladimir; Rubio Moscardó, Fanny; Conesa, José Javier; Navarro, Pilar; Vicente García, Rubén, 1978-; Rivera Gil, Pilar, 1976- (Taylor & Francis, 2024)
    Pancreatic ductal adenocarcinoma remains a highly aggressive and untreatable cancer. There is a need to develop a new PDAC-associated antigen-targeting drug delivery system to tackle this disease. We validated choosing ...
  • Zinc favors triple-negative breast cancer's microenvironment modulation and cell plasticity
    Vogel-González, Marina; Musa-Afaneh, Dunia; Rivera Gil, Pilar, 1976-; Vicente García, Rubén, 1978- (MDPI, 2021)
    Triple-negative breast cancer (TNBC) tends to metastasize to the brain, a step that worsens the patient's prognosis. The specific hallmarks that determine successful metastasis are motility and invasion, microenvironment ...

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