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Browsing by Author "Valverde, M. A. (Miguel Ángel), 1963-"

Browsing by Author "Valverde, M. A. (Miguel Ángel), 1963-"

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  • Localization and regulation of trpv4 channels in CILIATED epithelia
    Lorenzo Moldero, Ivan (Universitat Pompeu Fabra, 2008-07-24)
    La neteja del moc i dels patògens dels pulmons, i el transport de gàmets i embrions en els òrgans reproductius de les femelles són funcions clau en els epitelis ciliats, tals com aquells que es troben presents en les vies ...
  • LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
    Serra, Selma A.; Stojakovic, Predrag; Amat, Ramon; Rubio Moscardó, Fanny; Latorre Doménech, Pablo, 1993-; Seisenbacher, Gerhard; Canadell, David; Böttcher, René; Aregger, Michael; Moffat, Jason; Nadal Clanchet, Eulàlia de; Valverde, M. A. (Miguel Ángel), 1963-; Posas Garriga, Francesc (National Academy of Sciences, 2021)
    Regulation of cell volume is essential for tissue homeostasis and cell viability. In response to hypertonic stress, cells need rapid electrolyte influx to compensate water loss and to prevent cell death in a process known ...
  • Modulation of T lymphocite activation by ORMDL3
    Carreras Sureda, Amado, 1986- (Universitat Pompeu Fabra, 2014-07-17)
    Genome wide association studies (GWAS) have pointed out ORMDL3 gene as a risk factor for several proinflammatory and autoimmune diseases. The protein encoded by this gene belongs to a family of transmembrane proteins of ...
  • Molecular determinants of TRPV4 channel regulation
    Garcia-Elias Heras, Anna (Universitat Pompeu Fabra, 2011-06-30)
    TRPV4 is a non-selective cation channel with a wide expression and multiple cellular and systemic functions. Described initially as an osmosensor, it can also be activated by temperature and cell swelling. Due to this ...
  • Murine ES-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation
    Rovira Clusellas, Meritxell; Delaspre, Fabien; Massumi, Mohammad; Serra Pascual, Selma A., 1981-; Valverde, M. A. (Miguel Ángel), 1963-; Lloreta Trull, Josep, 1958-; Dufresne, Marlène; Payré, Bruno; Konieczny, Stephen F.; Savatier, Pierre; Real, Francisco X.; Skoudy, Anouchka (Elsevier, 2008)
    Background & Aims: Acinar cells constitute 90% of the pancreas epithelium, are polarized, and secrete digestive enzymes. These cells play a crucial role in pancreatitis and pancreatic cancer. However, there are limited ...
  • Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death
    Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Pérez Asensio, Fernando; Reyes Navarro, Mario; Caballo, Carolina; Galán, Ana M.; Alameda Quitllet, Francisco; Escolar, Ginès; Opazo, Carlos M.; Planas, Anna; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Hindawi, 2013)
    Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and brain vessel cells. Immediately after the stroke, the ischemic ...
  • Piezo ion channels in cancer cell mechanotransduction
    Pardo Pastor, Carlos, 1989- (Universitat Pompeu Fabra, 2018-01-24)
    The mechanical dependence of transformation and metastasis is an emerging field, but the role of mechanosensitive channels has been largely omitted. This thesis focuses on the roles played by the mechanosensitive ion ...
  • Polarized NHE1 and SWELL1 regulate migration direction, efficiency and metastasis
    Zhang, Yuqi; Li, Yizeng; Thompson, Keyata N.; Stoletov, Konstantin; Yuan, Qinling; Bera, Kaustav; Lee, Se Jong; Zhao, Runchen; Kiepas, Alexander; Wang, Yao; Mistriotis, Panagiotis; Serra, Selma A.; Lewis, John D.; Valverde, M. A. (Miguel Ángel), 1963-; Martin, Stuart S.; Sun, Sean X.; Konstantopoulos, Konstantinos (Nature Research, 2022)
    Cell migration regulates diverse (patho)physiological processes, including cancer metastasis. According to the Osmotic Engine Model, polarization of NHE1 at the leading edge of confined cells facilitates water uptake, cell ...
  • Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation
    Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Palomer, Ernest; Ill-Raga, Gerard, 1982-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Roman Degano, Irene; Eraso Pichot, Abel; Alcolea, Daniel; Fortea, Juan; Núñez, Laura; Páez, Antonio; Alameda Quitllet, Francisco; Fernàndez Busquets, Xavier; Lleó, Alberto; Elosua Llanos, Roberto; Boada, Mercè; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Glycation and nitrotyrosination are pathological posttranslational modifications that make proteins prone to losing their physiological properties. Since both modifications are increased in Alzheimer's disease (AD) due to ...
  • Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset alzheimer's disease patients alter calcium homeostasis
    Rubio Moscardó, Fanny; Bosch Morató, Mònica, 1986-; Plata, Cristina; Gené, Gemma; Muñoz López, Francisco José, 1964-; Valverde, M. A. (Miguel Ángel), 1963-; Clarimón Echevarría, Jordi (Public Library of Science (PLoS), 2013)
    Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer’s disease (AD). Recently, ...
  • Regulation of BK channel by tungstate and its relevance for the control of vascular tone and intracellular signalling
    Fernández Mariño, Ana Isabel, 1984- (Universitat Pompeu Fabra, 2013-07-29)
    The large-conductance Ca2+- and voltage-gated K+ (BK) channel containing the pore-forming and the regulatory B1 subunits play a pivotal role in the control of arterial tone and modification of channel function is associated ...
  • Regulation of Piezo1 channels and its impact on cell division
    Carrillo García, Julia, 1993- (2021-09-30)
    This project has aimed to investigate the regulation of the mechanosensitive ion channel Piezo1 by proteins that sense and modify membrane curvature. Our second objective has been to study this interplay in the context of ...
  • Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies
    Carreño, Oriel; Corominas, Roser; Serra Pascual, Selma A., 1981-; Sintas, Cèlia; Fernández Castillo, Noelia; Vila Pueyo, Marta; Toma, Claudio; Gené, Gemma; Pons, Roser; Llaneza, Miguel; Sobrido, María Jesús; Grinberg, Daniel; Valverde, M. A. (Miguel Ángel), 1963-; Fernández-Fernández, José Manuel, 1967-; Macaya, Alfons; Cormand, Bru (Wiley, 2013)
    Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in four genes (CACNA1A, ATP1A2, SCN1A and PRRT2) have ...
  • Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
    Sánchez, Alicia; Alvarez, Julio L.; Demydenko, Kateryna; Jung, Carole; Alpizar, Yeranddy A.; Alvárez Collazo, Julio; Cokic, Stevan M.; Valverde, M. A. (Miguel Ángel), 1963-; Hoet, Peter H.M.; Talavera, Karel (BioMed Central, 2017)
    BACKGROUND: Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure ...
  • Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
    Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Brouwers, Nathalie; Mitrovic, Sandra; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (American Society for Biochemistry and Molecular Biology (ASBMB), 2019)
    Regulated mucin secretion is essential for the formation of the mucus layer that protects the underlying epithelial cells from foreign particles. Alterations in the quantity or quality of secreted mucins are therefore ...
  • Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
    Berna Erro, Alejandro; Izquierdo Serra, Mercè; Sepúlveda, Romina V.; Rubio Moscardó, Fanny; Doñate-Macián, Pau; Serra Pascual, Selma A., 1981-; Carrillo García, Julia, 1993-; Perálvarez Marín, Alex; González Nilo, Fernando; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2017)
    TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 ...
  • Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
    Doñate-Macián, Pau; Duarte, Yorley; Rubio Moscardo, Fanny; Pérez Vilaró, Gemma, 1985-; Canan, Jonathan; Díez Antón, Juana, 1962-; González Nilo, Fernando; Valverde, M. A. (Miguel Ángel), 1963- (Wiley, 2020)
    Background and purpose: The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting ...
  • The fluid shear stress sensor TRPM7 regulates tumor cell intravasation
    Yankaskas, Christopher L.; Bera, Kaustav; Stoletov, Konstantin; Serra, Selma A.; Carrillo García, Julia, 1993-; Tuntithavornwat, Soontorn; Mistriotis, Panagiotis; Lewis, John D.; Valverde, M. A. (Miguel Ángel), 1963-; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2021)
    Tumor cell intravasation preferentially occurs in regions of low fluid shear because high shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells avoid high shear during intravasation. ...
  • The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
    Carrillo García, Julia, 1993-; Herrera-Fernández, Víctor; Serra, Selma A.; Rubio Moscardó, Fanny; Vogel-González, Marina; Doñate-Macián, Pau; Hevia, Covadonga F.; Pujades Corbi, Cristina; Valverde, M. A. (Miguel Ángel), 1963- (American Association for the Advancement of Science (AAAS), 2021)
    Mechanical forces are exerted throughout cytokinesis, the final step of cell division. Yet, how forces are transduced and affect the signaling dynamics of cytokinetic proteins remains poorly characterized. We now show that ...
  • The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
    Venturini, Valeria; Pezzano, Fabio; Català Castro, Frederic; Häkkinen, Hanna-Maria; Jiménez-Delgado, Senda; Colomer-Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-López, Sonia; Valverde, M. A. (Miguel Ángel), 1963-; Weghuber, Julian; Loza-Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena (American Association for the Advancement of Science (AAAS), 2020)
    The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints ...