Visualitza per autoria "Valverde, M. A. (Miguel Ángel), 1963-"

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  • Posttranslational nitro-glycative modifications of albumin in Alzheimer's disease: implications in cytotoxicity and amyloid-β peptide aggregation
    Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Palomer, Ernest; Ill-Raga, Gerard, 1982-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Roman Degano, Irene; Eraso Pichot, Abel; Alcolea, Daniel; Fortea, Juan; Núñez, Laura; Páez, Antonio; Alameda Quitllet, Francisco; Fernàndez Busquets, Xavier; Lleó, Alberto; Elosua Llanos, Roberto; Boada, Mercè; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Glycation and nitrotyrosination are pathological posttranslational modifications that make proteins prone to losing their physiological properties. Since both modifications are increased in Alzheimer's disease (AD) due to ...
  • Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset alzheimer's disease patients alter calcium homeostasis
    Rubio Moscardó, Fanny; Bosch Morató, Mònica, 1986-; Plata, Cristina; Gené, Gemma; Muñoz López, Francisco José, 1964-; Valverde, M. A. (Miguel Ángel), 1963-; Clarimón Echevarría, Jordi (Public Library of Science (PLoS), 2013)
    Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer’s disease (AD). Recently, ...
  • Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies
    Carreño, Oriel; Corominas, Roser; Serra Pascual, Selma A., 1981-; Sintas, Cèlia; Fernández Castillo, Noelia; Vila Pueyo, Marta; Toma, Claudio; Gené, Gemma; Pons, Roser; Llaneza, Miguel; Sobrido, María Jesús; Grinberg, Daniel; Valverde, M. A. (Miguel Ángel), 1963-; Fernández-Fernández, José Manuel, 1967-; Macaya, Alfons; Cormand, Bru (Wiley, 2013)
    Hemiplegic migraine (HM) is a rare and severe subtype of autosomal dominant migraine, characterized by a complex aura including some degree of motor weakness. Mutations in four genes (CACNA1A, ATP1A2, SCN1A and PRRT2) have ...
  • Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells
    Sánchez, Alicia; Alvarez, Julio L.; Demydenko, Kateryna; Jung, Carole; Alpizar, Yeranddy A.; Alvárez Collazo, Julio; Cokic, Stevan M.; Valverde, M. A. (Miguel Ángel), 1963-; Hoet, Peter H.M.; Talavera, Karel (BioMed Central, 2017)
    BACKGROUND: Silica nanoparticles (SiNPs) have numerous beneficial properties and are extensively used in cosmetics and food industries as anti-caking, densifying and hydrophobic agents. However, the increasing exposure ...
  • Sodium channel TRPM4 and sodium/calcium exchangers (NCX) cooperate in the control of Ca2+-induced mucin secretion from goblet cells
    Cantero Recasens, Gerard, 1984-; Butnaru, Cristian M.; Brouwers, Nathalie; Mitrovic, Sandra; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (American Society for Biochemistry and Molecular Biology (ASBMB), 2019)
    Regulated mucin secretion is essential for the formation of the mucus layer that protects the underlying epithelial cells from foreign particles. Alterations in the quantity or quality of secreted mucins are therefore ...
  • Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
    Berna Erro, Alejandro; Izquierdo Serra, Mercè; Sepúlveda, Romina V.; Rubio Moscardó, Fanny; Doñate-Macián, Pau; Serra Pascual, Selma A., 1981-; Carrillo García, Julia, 1993-; Perálvarez Marín, Alex; González Nilo, Fernando; Fernández-Fernández, José Manuel, 1967-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2017)
    TRPV4 cation channel activation by cytochrome P450-mediated derivatives of arachidonic acid (AA), epoxyeicosatrienoic acids (EETs), constitute a major mechanisms of endothelium-derived vasodilatation. Besides, TRPV4 ...
  • Structural determinants of TRPV4 inhibition and identification of new antagonists with antiviral activity
    Doñate-Macián, Pau; Duarte, Yorley; Rubio Moscardo, Fanny; Pérez Vilaró, Gemma, 1985-; Canan, Jonathan; Díez Antón, Juana, 1962-; González Nilo, Fernando; Valverde, M. A. (Miguel Ángel), 1963- (Wiley, 2022)
    Background and purpose: The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting ...
  • The fluid shear stress sensor TRPM7 regulates tumor cell intravasation
    Yankaskas, Christopher L.; Bera, Kaustav; Stoletov, Konstantin; Serra, Selma A.; Carrillo García, Julia, 1993-; Tuntithavornwat, Soontorn; Mistriotis, Panagiotis; Lewis, John D.; Valverde, M. A. (Miguel Ángel), 1963-; Konstantopoulos, Konstantinos (American Association for the Advancement of Science (AAAS), 2021)
    Tumor cell intravasation preferentially occurs in regions of low fluid shear because high shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells avoid high shear during intravasation. ...
  • The mechanosensitive Piezo1 channel controls endosome trafficking for an efficient cytokinetic abscission
    Carrillo García, Julia, 1993-; Herrera-Fernández, Víctor; Serra, Selma A.; Rubio Moscardó, Fanny; Vogel-González, Marina; Doñate-Macián, Pau; Hevia, Covadonga F.; Pujades Corbi, Cristina; Valverde, M. A. (Miguel Ángel), 1963- (American Association for the Advancement of Science (AAAS), 2021)
    Mechanical forces are exerted throughout cytokinesis, the final step of cell division. Yet, how forces are transduced and affect the signaling dynamics of cytokinetic proteins remains poorly characterized. We now show that ...
  • The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior
    Venturini, Valeria; Pezzano, Fabio; Català Castro, Frederic; Häkkinen, Hanna-Maria; Jiménez-Delgado, Senda; Colomer-Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-López, Sonia; Valverde, M. A. (Miguel Ángel), 1963-; Weghuber, Julian; Loza-Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena (American Association for the Advancement of Science (AAAS), 2020)
    The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints ...
  • The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity
    Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...
  • Transient receptor potential genes, smoking, occupational exposures and cough in adults
    Smit, Lidwien AM; Kogevinas, Manolis; Antó i Boqué, Josep Maria; Bouzigon, Emmanuelle; González Ruiz, Juan Ramón; Moual, Nicole Le; Kromhout, Hans; Carsin, Anne-Elie; Pin, Isabelle; Jarvis, Deborah; Vermeulen, Roel; Janson, Christer; Heinrich, Joachim; Gut, Ivo Glynne; Lathrop, Mark; Valverde, M. A. (Miguel Ángel), 1963-; Demenais, Florence; Kauffmann, Francine (BioMed Central, 2012)
    Background: Transient receptor potential (TRP) vanilloid and ankyrin cation channels are activated by various noxious chemicals and may play an important role in the pathogenesis of cough. The aim was to study the influence ...
  • TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells
    Mitrovic, Sandra; Nogueira, Cristina; Cantero Recasens, Gerard, 1984-; Kiefer, Kerstin, 1986-; Fernández-Fernández, José Manuel, 1967-; Popoff, Jean-François; Casano, Laetitia; Bard, Frederic A.; Gómez, Raul; Valverde, M. A. (Miguel Ángel), 1963-; Malhotra, Vivek (eLife, 2013)
    Mucin 5AC (MUC5AC) is secreted by goblet cells of the respiratory tract and, surprisingly, also expressed de novo in mucus secreting cancer lines. siRNA-mediated knockdown of 7343 human gene products in a human colonic ...
  • TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells
    Alpizar, Yeranddy A.; Boonen, Brett; Sánchez, Alicia; Jung, Carole; López-Requena, Alejandro; Naert, Robbe; Steelant, Brecht; Luyts, Katrien; Plata, Cristina; Vooght, Vanessa De; Vanoirbeek, Jeroen A.J.; Meseguer, Victor M.; Voets, Thomas; Alvarez, Julio L.; Hellings, Peter W.; Hoet, Peter H.M.; Nemery, Benoit; Valverde, M. A. (Miguel Ángel), 1963-; Talavera, Karel (Nature Publishing Group, 2017)
    Lipopolysaccharides (LPS), the major components of the wall of gram-negative bacteria, trigger powerful defensive responses in the airways via mechanisms thought to rely solely on the Toll-like receptor 4 (TLR4) immune ...
  • Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle
    Fernández Mariño, Ana Isabel, 1984-; Cidad, Pilar; Zafra, Delia; Nocito, Laura; Domínguez, Jorge; Oliván Viguera, Aida; Köhler, Ralf; López López, José R.; Pérez García, María Teresa; Valverde, M. A. (Miguel Ángel), 1963-; Guinovart, Joan J. (Joan Josep), 1947-; Fernández-Fernández, José Manuel, 1967- (Public Library of Science (PLoS), 2015)
    Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular ...
  • Vitamin E but not 17B-estradiol protect against vascular toxicity induced by B-amyloid wild type and the Dutch amyploid variant
    Muñoz López, Francisco José, 1964-; Opazo, Carlos M.; Gil Gómez, Gabriel; Tapia, Gladys; Fernández, Virginia; Valverde, M. A. (Miguel Ángel), 1963-; Inestrosa, Nibaldo C. (Society for Neuroscience, 2002)
    Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...

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