Browsing by Author "Tardón, Adonina"

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  • Genetic variation in the TP53 pathway and bladder cancer risk: a comprehensive analysis
    Pineda, Silvia; Milne, Roger L.; Calle, M. Luz; Rothman, Nathaniel; López De Maturana, Evangelina; Herranz, Jesús; Kogevinas, Manolis; Chanock, Stephen J.; Tardón, Adonina; Márquez, Mirari; Guey, Lin T.; García Closas, Montserrat; Lloreta Trull, Josep, 1958-; Baum, Erin; González Neira, Anna; Carrato, Alfredo; Navarro i Cuartiellas, Arcadi, 1969-; Silverman, Debra T.; Real, Francisco X.; Malats i Riera, Núria (Public Library of Science (PLoS), 2014)
    Introduction: Germline variants in TP63 have been consistently associated with several tumors, including bladder cancer, indicating the importance of TP53 pathway in cancer genetic susceptibility. However, variants in other ...
  • Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
    Morales, Eva; Vilahur Chiaraviglio, Nadia, 1982-; Salas Díaz, Lucas Andrés, 1980-; Motta, Valeria; Fernandez, Mariana F.; Murcia, Mario; Llop, Sabrina; Tardón, Adonina; Fernandez-Tardon, Guillermo; Santa Marina, Loreto; Gallastegui, Mara; Bollati, Valentina; Estivill, Xavier, 1955-; Olea, Nicolás; Sunyer Deu, Jordi; Bustamante Pineda, Mariona (Oxford University Press, 2016)
    BACKGROUND: We conducted an epigenome-wide association study (EWAS) of DNA methylation in placenta in relation to maternal tobacco smoking during pregnancy and examined whether smoking-induced changes lead to low birthweight. ...
  • Genomic DNA hypomethylation as a biomarker for bladder cancer susceptibility in the Spanish Bladder Cancer Study: a case-control study
    Moore, Lee E.; Pfeiffer, Ruth M.; Poscablo, Cristina; Real, Francisco X.; Kogevinas, Manolis; Silverman, Debra T.; García Closas, Reina; Chanock, Stephen J.; Tardón, Adonina; Serra, Consol; Carrato, Alfredo; Dosemeci, Mustafa; García Closas, Montserrat; Esteller, Manel; Fraga, Mario F.; Rothman, Nathaniel; Malats i Riera, Núria (Elsevier, 2008)
    BACKGROUND: DNA hypomethylation has been suggested to cause genomic instability and increase cancer risk. We aimed to test the hypothesis that DNA hypomethylation is associated with increased risk of bladder cancer. METHODS: ...
  • Insulin-like growth factor levels and chronic lymphocytic leukaemia: results from the MCC-Spain and EpiLymph-Spain studies
    Casabonne, Delphine; Benavente, Yolanda; Costas, Laura; Robles Hellín, Claudia, 1980-; González, Eva; de la Banda, Esmeralda; Alonso, Esther; Aymerich, Marta; Campo, Elias; Marcos-Gragera, Rafael; Tardón, Adonina; Olmedo-Requena, Rocío; Gimeno Vázquez, Eva; Martınez-Lopez, Alba; Casanovas, Oriol; Castaño Vinyals, Gemma; Aragonés, Núria; Pollan, Marina; Kogevinas, Manolis; de Sanjosé, Silvia (Wiley-Blackwell, 2019)
  • LINE-1 methylation in granulocyte DNA and trihalomethane exposure is associated with bladder cancer risk
    Salas, Lucas A.; Villanueva Belmonte, Cristina; Tajuddin, Salman Muhammad; Amaral, André F.S.; Fernández, Agustín F.; Moore, Lee E.; Carrato, Alfredo; Tardón, Adonina; Serra, Consol; García Closas, Reina; Basagaña Flores, Xavier; Rothman, Nathaniel; Silverman, Debra T.; Cantor, Kenneth P; Kogevinas, Manolis; Real, Francisco X.; Fraga, Mario F.; Malats i Riera, Núria (Taylor & Francis (Routledge), 2014)
    DNA methylation changes contribute to bladder carcinogenesis. Trihalomethanes (THM), a class of disinfection by-products, are associated with increased urothelial bladder cancer (UBC) risk. THM exposure in animal models ...
  • LINE-1 methylation in leukocyte DNA, interaction with phosphatidylethanolamine N-methyltransferase variants and bladder cancer risk
    Amaral, André F.S.; Tajuddin, Salman Muhammad; Fernández, Agustín F.; Chanock, Stephen J.; Silverman, Debra T.; Tardón, Adonina; Carrato, Alfredo; García Closas, Montserrat; Jackson, Brian P.; Toraño, Estela; Márquez, Miriam; González Urdinguio, Rocío; García Closas, Reina; Rothman, Nathaniel; Kogevinas, Manolis; Real, Francisco X.; Fernández Fraga, Mario; Malats i Riera, Núria (Cancer Research UK, 2014)
    Background: Aberrant global DNA methylation is shown to increase cancer risk. LINE-1 has been proven a measure of global DNA methylation. The objectives of this study were to assess the association between LINE-1 methylation ...
  • Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood
    López Vicente, Mònica, 1988-; Sunyer Deu, Jordi; Lertxundi, Nerea; González-Safont, Llúcia; Rodríguez Dehli, Cristina; Espada Sáenz-Torre, Mercedes; Vrijheid, Martine; Tardón, Adonina; Llop, Sabrina; Torrent Quetglas, Maties; Ibarluzea, Jesús; Guxens Junyent, Mònica (Nature Research, 2019)
    Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed to assess the association between maternal vitamin D3, the major circulatory form of vitamin D, at pregnancy ...
  • Maternal consumption of seafood in pregnancy and child neuropsychological development: a longitudinal study based on a population with high consumption levels
    Júlvez Calvo, Jordi; Mendez, Michelle A.; Fernández-Barrés, Sílvia; Romaguera Bosch, Dora; Vioque, Jesus; Llop, Sabrina; Ibarluzea, Jesús; Guxens Junyent, Mònica; Avella García, Claudia B., 1982-; Tardón, Adonina; Riaño, Isolina; Andiarena, Ainara; Robinson, Oliver; Arija, Victoria; Esnaola, Mikel; Ballester Díez, Ferran; Sunyer Deu, Jordi (Oxford University Press, 2016)
    Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but to our knowledge no large cohort studies with high fatty fish consumption have analyzed the association by ...
  • Maternal pre-pregnancy obesity and neuropsychological development in pre-school children: a prospective cohort study
    Casas Sanahuja, Maribel; Forns i Guzman, Joan, 1981-; Martínez Muriano, David; Guxens Junyent, Mònica; Fernández-Somoano, Ana; Ibarluzea, Jesús; Lertxundi, Nerea; Murcia, Mario; Rebagliato, Marisa; Tardón, Adonina; Sunyer Deu, Jordi; Vrijheid, Martine (Nature Publishing Group, 2017)
    BackgroundMaternal pre-pregnancy obesity may impair infant neuropsychological development, but it is unclear whether intrauterine or confounding factors drive this association.MethodsWe assessed whether maternal pre-pregnancy ...
  • Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome
    Rodríguez Santiago, Benjamín; Malats i Riera, Núria; Rothman, Nathaniel; Armengol i Dulcet, Lluís; García Closas, Montserrat; Kogevinas, Manolis; Villa, Olaya; Hutchinson, Amy; Earl, Julie; Marenne, Gaëlle; Jacobs, Kevin; Rico, Daniel; Tardón, Adonina; Carrato, Alfredo; Thomas, Gilles; Valencia, Alfonso; Silverman, Debra T.; Real, Francisco X.; Chanock, Stephen J.; Pérez Jurado, Luis Alberto (Elsevier, 2010)
    Mosaicism is defined as the coexistence of cells with different genetic composition within an individual, caused by postzygotic somatic mutation. Although somatic mosaicism for chromosomal abnormalities is a well-established ...
  • Omega-3 fatty acid intake during pregnancy and child neuropsychological development: A Multi-Centre Population-Based Birth cohort study in Spain
    Tahaei, Hana; Gignac, Florence; Pinar, Ariadna; Fernandez-Barrés, Silvia; Romaguera Bosch, Dora; Vioque, Jesus; Santa-Marina, Loreto; Subiza-Pérez, Mikel; Llop, Sabrina; Soler Blasco, Raquel; Arija, Victoria; Salas-Salvadó, Jordi; Tardón, Adonina; Riaño-Galán, Isolina; Sunyer Deu, Jordi; Guxens Junyent, Mònica; Júlvez Calvo, Jordi (MDPI, 2022)
    Background: There are few studies that look at the intake of all types of omega-3 polyunsaturated fatty acids (n-3 PUFAs) during the different stages of pregnancy along with a long-term neuropsychological follow-up of the ...
  • Polymorphisms in GSTT1, GSTZ1, AND CYP2E1, disinfection by-products, and risk of bladder cancer in Spain
    Cantor, Kenneth P; Villanueva Belmonte, Cristina; Silverman, Debra T.; Figueroa, Jonine D.; Real, Francisco X.; García Closas, Montserrat; Malats i Riera, Núria; Chanock, Stephen J.; Yeager, Meredith; Tardón, Adonina; García Closas, Reina; Serra, Consol; Carrato, Alfredo; Castaño Vinyals, Gemma; Samanic, Claudine; Rothman, Nathaniel; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2010)
    Background: Bladder cancer has been linked with long-term exposure to disinfection by-products (DBPs) in drinking water.Objectives: In this study we investigated the combined influence of DBP exposure and polymorphisms in ...
  • Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design
    Castano-Vinyals, Gemma; Aragonés, Núria; Pérez-Gómez, Beatriz; Martín, Vicente; Llorca, Javier; Moreno, Víctor; Altzibar, Jone Miren; Ardanaz, Eva; Sanjosé Llongueras, Silvia de; Jiménez-Moleón, José Juan; Tardón, Adonina; Alguacil, Juan; Peiró, Rosana; Marcos-Gragera, Rafael; Navarro, Carmen; Pollán, Marina; Kogevinas, Manolis; MCC-Spain Study Group (Elsevier, 2015)
    Introduction. We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods. Between 2008-2013, 10,183 ...
  • Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study
    Carrasco, Paula; Estarlich, Marisa; Iñiguez, Carmen; Ferrero, Amparo; Murcia, Mario; Esplugues, Ana; Vioque, Jesus; Santa Marina, Loreto; Zabaleta, Carlos; Iriarte, Gorka; Fernández-Somoano, Ana; Tardón, Adonina; Vrijheid, Martine; Sunyer Deu, Jordi; Ballester Díez, Ferran; Llop, Sabrina (Elsevier, 2021)
    Effects of mercury on maturing immune system have been reported, however the association with respiratory and allergy problems during infancy remains unclear. The aim of this study is to evaluate the association between ...
  • Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models.
    López De Maturana, Evangelina; Picornell, Antoni; Masson-Lecomte, Alexandra; Kogevinas, Manolis; Márquez, Mirari; Carrato, Alfredo; Tardón, Adonina; Lloreta Trull, Josep, 1958-; García Closas, Montserrat; Silverman, Debra T.; Rothman, Nathaniel; Chanock, Stephen J.; Real, Francisco X.; Goddard, M. E.; Malats i Riera, Núria; SBC/EPICURO Study Investigators (BioMed Central, 2016)
    BACKGROUND: We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to ...
  • Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
    Fossati, Serena; Valvi, Damaskini, 1983-; Martínez, David; Cirach, Marta; Estarlich, Marisa; Fernández-Somoano, Ana; Guxens Junyent, Mònica; Iñiguez, Carmen; Irizar, Amaia; Lertxundi, Aitana; Nieuwenhuijsen, Mark J.; Tamayo-Uria, Ibon; Vioque, Jesus; Tardón, Adonina; Sunyer Deu, Jordi; Vrijheid, Martine (Elsevier, 2020)
    Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of pregnancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth ...
  • Prenatal and postnatal exposure to NO2 and child attentional function at 4-5 years of age
    Sentís, Alexis; Sunyer Deu, Jordi; Dalmau Bueno, Albert; Andiarena, Ainara; Ballester Díez, Ferran; Cirach, Marta; Estarlich, Marisa; Fernández-Somoano, Ana; Ibarluzea, Jesús; Íñiguez, Carmen; Lertxundi, Aitana; Tardón, Adonina; Nieuwenhuijsen, Mark J.; Vrijheid, Martine; Guxens Junyent, Mònica (Elsevier, 2017)
    BACKGROUND: Prenatal and postnatal exposure to air pollution has been linked to cognitive impairment in children, but very few studies have assessed its association with attentional function. OBJECTIVES: To evaluate the ...
  • Prenatal exposure to cooking gas and respiratory health in infants is modified by tobacco smoke exposure and diet in the INMA birth cohort study
    Esplugues, Ana; Estarlich, Marisa; Sunyer Deu, Jordi; Fuentes Leonarte, Virginia; Basterrechea, Mikel; Vrijheid, Martine; Riaño, Isolina; Santa Marina, Loreto; Tardón, Adonina (BioMed Central, 2013)
    BACKGROUND: Studies that have evaluated the association between exposure to gas appliances emissions at home with respiratory health in children obtained heterogeneous and limited results. The aim of this study is to analyze ...
  • Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children
    Ibarluzea, Jesús; Gallastegi, Mara; Santa Marina, Loreto; Jiménez-Zabala, Ana; Arranz, Enrique; Molinuevo, Amaia; Lopez-Espinosa, Maria-José; Ballester Díez, Ferran; Villanueva, Cristina M.; Riano-Galan, Isolina; Sunyer Deu, Jordi; Tardón, Adonina; Lertxundi, Aitana (Elsevier, 2022)
    Background: Cross-sectional and prospective studies have provided evidence of the neurotoxic effect of early exposure to fluoride (F) in pregnancy. It has been negatively associated with cognitive development during ...
  • Prenatal exposure to mixtures of xenoestrogens and genome-wide DNA methylation in human placenta
    Vilahur Chiaraviglio, Nadia, 1982-; Bustamante Pineda, Mariona; Morales, Eva; Motta, Valeria; Fernandez, Mariana F.; Salas, Lucas A.; Escaramís, Geòrgia; Ballester Díez, Ferran; Murcia, Mario; Tardón, Adonina; Riaño, Isolina; Santa Marina, Loreto; Ibarluzea, Jesús; Arrebola, Juan Pedro; Estivill, Xavier, 1955-; Bollati, Valentina; Sunyer Deu, Jordi; Olea, Nicolás (Future Medicine, 2016)
    BACKGROUND: In utero exposure to xenostrogens may modify the epigenome. We explored the association of prenatal exposure to mixtures of xenoestrogens and genome-wide placental DNA methylation. MATERIALS & METHODS: Sex-specific ...