Browsing by Author "Subirana Cachinero, Isaac"

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  • High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study
    Prats Uribe, Albert; Sayols Baixeras, Sergi, 1988-; Fernández Sanlés, Alba, 1988-; Subirana Cachinero, Isaac; Carreras-Torres, Robert; Vilahur, Gemma; Civeira, Fernando; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Hernáez, Álvaro; Elosua Llanos, Roberto (Elsevier, 2020)
    Background: To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). Methods: We designed a two-sample multivariate Mendelian ...
  • Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction
    Lucas, Gavin, 1977-; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Musameh, Muntaser D.; González Ruiz, Juan Ramón; Nelson, Christopher P.; Sentí Clapés, Mariano; Myocardial Infarction Genetics; Wellcome Trust Case Control Constortium; Schwartz, Stephen M; Siscovick, David; O'Donnell, Christopher J; Melander, Olle; Salomaa, Veikko; Purcell, Shaun; Altshuler, David; Samani, Nilesh J.; Kathiresan, Sekar; Elosua Llanos, Roberto (Public Library of Science (PLoS), 2012)
    The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential ...
  • Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.
    Sayols, Sergi; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Civeira, Fernando; Roquer, Jaume; Do, AN; Absher, Devin; Cenarro, A.; Muñoz, Dani; Soriano Tarraga, Carolina; Jiménez Conde, Jordi; Ordovás, José M.; Sentí Clapés, Mariano; Aslibekyan, Stella W.; Marrugat de la Iglesia, Jaume; Arnett, Donna K.; Elosua Llanos, Roberto (Oxford University Press, 2016)
    Lipid traits (total, low-densityand high-density lipoproteincholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is an inherited but also modifiable epigenetic mark ...
  • Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study.
    Sayols, Sergi; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Lucas A.; Vilahur Chiaraviglio, Nadia, 1982-; Corella, Dolores; Muñoz, Dani; Segura, Antoni, 1952-; Jiménez Conde, Jordi; Moran, Sebastian; Soriano Tarraga, Carolina; Roquer, Jaume; Lopez-Farré, Antonio; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Taylor & Francis, 2015)
    Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at ...
  • Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial
    Farràs Mañé, Marta; Swann, Jonathan Richard; Rowland, Ian; Rubió, Laura; Subirana Cachinero, Isaac; Catalán, Úrsula; Motilva, Maria-José; Solà, Rosa; Covas Planells, Maria Isabel; Blanco-Vaca, Francisco; Fitó Colomer, Montserrat; Mayneris Perxachs, Jordi (MDPI, 2022)
    Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A ...
  • Importancia pronóstica de la enfermedad arterial periférica diagnosticada mediante el índice tobillo-brazo en población general española
    Félix-Redondo, Francisco Javier; Subirana Cachinero, Isaac; Baena Díez, Jose M.; Ramos, Rafel; Cancho, Bárbara; Fernández-Bergés, Daniel; Roberto Robles, Nicolás (Elsevier, 2020)
    Objetivo: Determinar el valor pronóstico de tener un índice tobillo-brazo (ITB) bajo para padecer distintas enfermedades cardiovasculares y si mejora la capacidad predictiva de las principales funciones de riesgo cardiovascular. ...
  • In-hospital prognosis and long-term mortality of STEMI in a reperfusion network. "Head to head" analisys: invasive reperfusion vs optimal medical therapy
    García-García, Cosme; Ribas Barquet, Núria; Recasens, Lluís; Meroño, Oona; Subirana Cachinero, Isaac; Fernández, A.; Pérez, Ana; Miranda, F.; Tizón-Marcos, Helena; Martí-Almor, Julio; Bruguera-Cortada, Jordi; Elosua Llanos, Roberto (BioMed Central, 2017)
    BACKGROUND: ST Segment Elevation Acute myocardial infarction (STEMI) preferred treatment is culprit artery reperfusion with primary percutaneous coronary intervention (PPCI). We ought to analyze the benefit of early ...
  • Marcadores de daño miocárdico en la predicción del pronóstico a corto plazo de los pacientes con COVID-19
    Calvo-Fernández, Alicia; Izquierdo Marquisa, Andrea; Subirana Cachinero, Isaac; Farré López, Núria; Vila, Joan; Duran, Xavier; Garcia Guimaraes, Marcos; Valdivielso, Sandra; Cabero, Paula; Soler, Cristina; García-Ribas, Cora; Rodríguez¸ Clara; Llagostera Martín, Marc; Mojón Álvarez, Diana; Vicente Elcano, Miren; Solé-González, Eduard; Sánchez Carpintero, Andrea; Tevar Gómez, Cristina; Marrugat de la Iglesia, Jaume; Vaquerizo Montilla, Beatriz (Elsevier, 2021)
    Introducción y objetivos: La información sobre el daño miocárdico en la población con COVID-19 es muy escasa. Nuestro objetivo fue evaluar el daño cardiaco en pacientes con COVID-19 y determinar la correlación entre las ...
  • Mortality risk prediction dynamics after heart failure treatment optimization: repeat risk assessment using online risk calculators
    Codina, Pau; Zamora, Elisabet; Levy, Wayne C.; Revuelta-López, Elena; Borrellas, Andrea; Spitaleri, Giosafat; Cediel, German; Ruiz-Cueto, María; Cañedo, Elena; Santiago-Vacas, Evelyn; Domingo, Mar; Buchaca, David; Subirana Cachinero, Isaac; Santesmases, Javier; de la Espriella, Rafael; Núñez, Julio; Lupón, Josep; Bayes-Genis, Antoni (Frontiers, 2022)
    Objectives: heart failure (HF) management has significantly improved over the past two decades, leading to better survival. This study aimed to assess changes in predicted mortality risk after 12 months of management in a ...
  • Olive oil polyphenols decrease LDL concentrations and LDL atherogenicity in men in a randomized controlled trial.
    Hernáez, Álvaro; Remaley, Alan T.; Farràs Mañé, Marta; Fernández-Castillejo, Sara; Subirana Cachinero, Isaac; Schröder, Helmut, 1958-; Fernández-Mampel, Mireia; Muñoz Aguayo, Daniel; Sampson, Maureen; Solà, Rosa; Farré Albaladejo, Magí; Torre Fornell, Rafael de la; López Sabater, M. Carmen; Nyyssönen, Kristiina; Zunft, Hans-Joachim F.; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat (American Society for Nutrition, 2015)
    BACKGROUND: Olive oil polyphenols have shown protective effects on cardiovascular risk factors. Their consumption decreased oxidative stress biomarkers and improved some features of the lipid profile. However, their effects ...
  • Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease
    Dégano, Irene R.; Subirana Cachinero, Isaac; Fusco, Danilo; Tavazzi, Luigi; Kirchberger, Inge; Farmakis, Dimitrios; Ferrières, Jean; Azevedo, Ana; Torre, Marina; Garel, Pascal; Brosa, Max; Davoli, Marina; Meisinger, Christa; Bongard, Vanina; Araújo, Carla; Lekakis, John; Francés, Albert; Castell, Conxa; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; EUROTRACS investigators (Elsevier, 2017)
    BACKGROUND: Percutaneous coronary intervention (PCI) reduces mortality in most myocardial infarction (MI) patients but the effect on elderly patients with comorbidities is unclear. Our aim was to analyse the effect of PCI ...
  • Prediction of coronary disease incidence by biomarkers of inflammation, oxidation, and metabolism
    Subirana Cachinero, Isaac; Fitó Colomer, Montserrat; Díaz Gil, Oscar; Vila, Joan; Francés, Albert; Delpon, Eva; Sanchís, Juan; Elosua Llanos, Roberto; Muñoz-Aguayo, D.; Dégano, Irene R.; Marrugat de la Iglesia, Jaume (Nature Research, 2019)
    The effect of circulating biomarkers in predicting coronary artery disease (CAD) is not fully elucidated. This study aimed to determine the relationship with CAD and the predictive capacity of nine biomarkers of inflammation ...
  • Prognostic implications of chronic heart failure and utility of NT-proBNP levels in heart failure patients with SARS-CoV-2 infection
    Belarte Tornero, Laia Carla; Valdivielso Moré, Sandra; Vicente Elcano, Miren; Solé-González, Eduard; Ruíz Bustillo, Sonia; Calvo-Fernández, Alicia; Subirana Cachinero, Isaac; Cabero, Paula; Soler, Cristina; Cubero Gallego, Héctor; Vaquerizo Montilla, Beatriz; Farré López, Núria (MDPI, 2021)
    Background: The prevalence and prognostic value of chronic heart failure (CHF) in the setting of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has seldom been studied. The aim of this study was to ...
  • Standardized comparison of cardiovascular risk factors prevalence in spanish women and men living with HIV and in the general population
    Camps-Vilaró, Anna; Pérez-Fernández, Silvia; Subirana Cachinero, Isaac; Teira, Ramón; Estrada, Vicente; Domingo, Pere; Dégano, Irene R.; Marrugat de la Iglesia, Jaume (MDPI, 2021)
    People living with HIV (PLWH) have an increased risk of cardiovascular (CV) disease, likely due to a higher prevalence of CV risk factors. We compared the age-standardized prevalence and management of CV risk factors in ...
  • Usefulness of cardiac computed tomography in coronary risk prediction: A five-year follow-up of the SPICA study (Secure Prevention with Imaging of the Coronary Arteries)
    Viladés-Medel, David; Dégano, Irene R.; Subirana Cachinero, Isaac; Descalzo, Martin; Padilla, Mireia; Mundet-Tudurí, Xavier; Carreras Costa, Francesc; Alomar Serrallach, Xavier; Camps-Vilaró, Anna; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; Leta Petracca, Rubén (MDPI, 2022)
    Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification ...
  • Validity, reliability, and calibration of the physical activity unit 7 item screener (PAU-7S) at population scale
    Schröder, Helmut, 1958-; Subirana Cachinero, Isaac; Gómez, Santiago Felipe (BioMed Central, 2021)
    Background: Validation of self-reported tools, such as physical activity (PA) questionnaires, is crucial. The aim of this study was to determine test-retest reliability, internal consistency, and the concurrent, construct, ...
  • Vitamin D supplementation and COVID-19 risk: a population-based, cohort study
    Oristrell, Joaquim; Oliva, Joan Carles; Casado, Enrique; Subirana Cachinero, Isaac; Domínguez Herrera, Didier; Toloba, Andrea; Balado, A.; Grau Magaña, Maria (Springer, 2022)
    Purpose: To analyze the associations between cholecalciferol or calcifediol supplementation, serum 25-hydroxyvitamin D (25OHD) levels and COVID-19 outcomes in a large population. Methods: All individuals ≥ 18 years old ...
  • Weighted multi-marker genetic risk scores for incident coronary heart disease among individuals of african, latino and east-asian ancestry
    Iribarren, Carlos; Lu, Meng; Jorgenson, Eric; Martínez, Manuel; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Eduardo; Elosua Llanos, Roberto (Nature Research, 2018)
    We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. ...