Browsing by Author "Salvadó, Gemma"

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  • Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Operto, Grégory; Falcón, Carles; Cacciaglia, Raffaele; Minguillón, Carolina; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (SpringerOpen, 2022)
    Purpose: glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid ...
  • Collij, Lyduine E.; Mastenbroek, Sophie E.; Salvadó, Gemma; Wink, Alle Meije; Visser, Pieter Jelle; Barkhof, Frederik; van Berckel, Bart N. M.; Lopes Alves, Isadora (Elsevier, 2021)
    Introduction: The value of quantitative longitudinal and regional amyloid beta (Aβ) measurements in predicting cognitive decline in initially cognitively unimpaired (CU) individuals remains to be determined. Methods: We ...
  • Salvadó, Gemma; Brugulat Serrat, Anna, 1986-; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2019)
    Background: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH associated with dementia ...
  • Collij, Lyduine E.; Salvadó, Gemma; Wottschel, Viktor; Mastenbroek, Sophie E.; Schoenmakers, Pierre; Heeman, Fiona; Aksman, Leon; Wink, Alle Meije; Berckel, Bart N.M.; van de Flier, Wiesje M.; Scheltens, Philip; Visser, Pieter Jelle; Barkhof, Frederik; Haller, Sven; Gispert López, Juan Domingo; Lopes Alves, Isadora; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage ...
  • Lopes Alves, Isadora; Heeman, Fiona; Collij, Lyduine E.; Salvadó, Gemma; Tolboom, Nelleke; Vilor Tejedor, Natàlia, 1988-; Markiewicz, Pawel; Yaqub, Maqsood; Cash, David; Mormino, Elizabeth C.; Insel, Philip S.; Boellaard, Ronald; van Berckel, Bart N. M.; Lammertsma, Adriaan A.; Barkhof, Frederik; Gispert López, Juan Domingo (BioMed Central, 2021)
    Background: Detecting subtle-to-moderate biomarker changes such as those in amyloid PET imaging becomes increasingly relevant in the context of primary and secondary prevention of Alzheimer's disease (AD). This work aimed ...
  • Cortés Canteli, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Toribio Fernández, Raquel; Tristão Pereira, Catarina; Falcón, Carles; Oliva, Belén; Mendiguren, José; Fernández Friera, Letícia; Sanz, Javier; García-Ruiz de Morales, José María; Fernández Ortiz, Antonio; Sánchez González, Javier; Ibáñez, Borja; Molinuevo, José Luis; Fuster, Valentín (Elsevier, 2021)
    Background: Atherosclerosis has been linked to cognitive decline in late life; however, the impact of cardiovascular risk factors (CVRFs) and subclinical atherosclerosis on brain metabolism at earlier stages remains ...
  • Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...
  • Salvadó, Gemma; Operto, Grégory; Cumplido-Mayoral, Irene; Arenaza Urquijo, Eider M.; Cacciaglia, Raffaele; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Minguillón, Carolina; Gispert López, Juan Domingo; ADNI (Wiley, 2022)
    Introduction: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired ...
  • Collij, Lyduine E.; Salvadó, Gemma; Shekari, Mahnaz; Lopes Alves, Isadora; Reimand, Juhan; Wink, Alle Meije; Zwan, Marissa; Niñerola-Baizán, Aida; Perissinotti, Andrés; Scheltens, Philip; Ikonomovic, Milos D.; Smith, Adrian P.L.; Farrar, Gill; Molinuevo, José Luis; Barkhof, Frederik; Buckley, Christopher, 1948-; van Berckel, Bart N. M. (Springer, 2021)
    Purpose: To investigate the sensitivity of visual read (VR) to detect early amyloid pathology and the overall utility of regional VR. Methods: [18F]Flutemetamol PET images of 497 subjects (ALFA+ N = 352; ADC N = 145) were ...

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