Browsing by Author "Sabidó Aguadé, Eduard, 1981-"

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  • High-throughput proteomics reveals the unicellular roots of animal phosphosignaling and cell differentiation
    Sebé-Pedrós, Arnau; Peña Paz, Marcia I.; Capella Gutiérrez, Salvador Jesús, 1985-; Antó Subirats, Meritxell; Gabaldón Estevan, Juan Antonio, 1973-; Ruiz Trillo, Iñaki; Sabidó Aguadé, Eduard, 1981- (Elsevier, 2016)
    Cell-specific regulation of protein levels and activity is essential for the distribution of functions among multiple cell types in animals. The finding that many genes involved in these regulatory processes have a premetazoan ...
  • Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
    Maitre, Léa; De Bont, Jeroen, 1989-; Casas Sanahuja, Maribel; Robinson, Oliver; Basagaña Flores, Xavier; Borràs, Eva; Bustamante Pineda, Mariona; de Castro, Montserrat; Donaire González, David; Estivill, Xavier, 1955-; Fossati, Serena; González, Juan Ramón; Hernández-Ferrer, Carles; Júlvez Calvo, Jordi; Manzano Salgado, Cyntia Beatriz, 1987-; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; van Gent, Diana; Vives Usano, Marta, 1990-; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Vrijheid, Martine (BMJ Publishing Group, 2018)
    PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and ...
  • The Human Early-Life Exposome (HELIX): project rationale and design
    Vrijheid, Martine; Robinson, Oliver; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; van Gent, Diana; González Ruiz, Juan Ramón; Júlvez Calvo, Jordi; Kogevinas, Manolis; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2014)
    Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure–health effect relationships. The ...
  • IKKα kinase regulates the DNA damage response and drives chemo-resistance in cancer
    Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; Villanueva, Alberto; Vert, Anna; Pecharroman, Irene; Solé, Laura; González-Farré, Mónica; Alonso, Josune; Montagut Viladot, Clara; Martínez Iniesta, María; Bertran, Joan; Borràs, Eva; Iglesias, Mar; Sabidó Aguadé, Eduard, 1981-; Bigas Salvans, Anna; Boulton, Simon J.; Espinosa Blay, Lluís (Elsevier, 2019)
    Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-¿B signaling. Insights into the sources ...
  • In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
    Vives Usano, Marta, 1990-; Hernández-Ferrer, Carles; Maitre, Léa; Ruiz Arenas, Carlos, 1990-; Borràs, Eva; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; González, Juan Ramón; Sabidó Aguadé, Eduard, 1981-; Vrijheid, Martine; Bustamante Pineda, Mariona (BioMed Central, 2020)
    Background: The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only ...
  • Inflammation in multiple sclerosis induces a specific reactive astrocyte state driving non-cell-autonomous neuronal damage
    Matute-Blanch, Clara; Brito, Verónica; Midaglia, Luciana; Villar, Luisa Maria; Garcia-Diaz Barriga, Gerardo; Guzman de la Fuente, Alerie; Borrás, Eva; Fernández-García, Sara; Calvo-Barreiro, Laura; Miguez, Andrés; Costa-Frossard, Lucienne; Pinteac, Rucsanda; Sabidó Aguadé, Eduard, 1981-; Alberch, Jordi; Fitzgerald, Denise C.; Montalbán Gairín, Xavier; Comabella López, Manuel (Wiley Open Access, 2022)
  • Inter-laboratory evaluation of instrument platforms and experimental workflows for quantitative accuracy and reproducibility assessment
    Percy, Andrew J.; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Borchers, Christoph H. (Elsevier, 2015)
    The reproducibility of plasma protein quantitation between laboratories and between instrument types was examined in a large-scale international study involving 16 laboratories and 19 LC–MS/MS platforms, using two kits ...
  • Isotopologue multipoint calibration for proteomics biomarker quantification in clinical practice
    Chiva, Cristina; Pastor, Olga; Trilla Fuertes, Lucía; Gámez Pozo, Angelo; Fresno Vara, Juan Ángel; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2019)
    Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproducibility, accuracy, and precision. However, for targeted proteomics to be transferred to ...
  • Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest
    Belužić, Lucija; Grbeša, Ivana; Belužić, Robert; Park, Jong Hoon; Kong, Hyun Kyung; Kopjar, Nevenka; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Lepur, Adriana; Rokić, Filip; Jerić, Ivanka; Brkljačić, Lidija; Vugrek, Oliver (Nature Research, 2018)
    Recently, functional connections between S-adenosylhomocysteine hydrolase (AHCY) activity and cancer have been reported. As the properties of AHCY include the hydrolysis of S-adenosylhomocysteine and maintenance of the ...
  • Machine learning-based health environmental-clinical risk scores in European children
    Guimbaud, Jean-Baptiste; Sabidó Aguadé, Eduard, 1981-; Borràs, Eva; Júlvez Calvo, Jordi; Urquiza, José M.; Casas Sanahuja, Maribel; Bustamante Pineda, Mariona; Nieuwenhuijsen, Mark J.; Vrijheid, Martine; López Vicente, Mònica, 1988-; de Castro, Montserrat; Basagaña Flores, Xavier; Maitre, Léa (Nature Research, 2024)
    Background: Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental ...
  • Mass spectrometry identification of biomarkers in extracellular vesicles from plasmodium vivax liver hypnozoite infections
    Gualdrón-López, Melisa; Díaz Varela, Míriam; Aparici-Herraiz, Iris; Cuscó Pons, Pol, 1987-; González, Juan Ramón; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Fernandez-Becerra, Carmen; del Portillo, Hernando A. (Elsevier, 2022)
    Latent liver stages termed hypnozoites cause relapsing Plasmodium vivax malaria infection and represent a major obstacle in the goal of malaria elimination. Hypnozoites are clinically undetectable, and presently, there are ...
  • MassIVE.quant: a community resource of quantitative mass spectrometry-based proteomics datasets
    Choi, Meena; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Vitek, Olga (Nature Research, 2020)
    MassIVE.quant is a repository infrastructure and data resource for reproducible quantitative mass spectrometry-based proteomics, which is compatible with all mass spectrometry data acquisition types and computational ...
  • Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
    Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Melanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
    Mestre-Farràs, Neus; Guerrero Jijon, Santiago Xavier; Bley, Nadine; Rivero, Ezequiel; Coll, Olga; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Indacochea Cusirramos, Alberto; Casillas-Serra, Carlos; Järvelin, Aino I.; Oliva Miguel, Baldomero; Castello, Alfredo; Hüttelmaier, Stefan; Gebauer, Fátima (Oxford University Press, 2022)
    RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture (RIC) to characterize the melanoma RBPome ...
  • Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis
    Colomé, Núria; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; EuPA (Elsevier, 2022)
    Global analysis of protein phosphorylation by mass spectrometry proteomic techniques has emerged in the last decades as a powerful tool in biological and biomedical research. However, there are several factors that make ...
  • Multi-omics signatures of the human early life exposome
    Maitre, Léa; Bustamante Pineda, Mariona; Hernández Ferrer, Carles; Vives Usano, Marta, 1990-; Ruiz-Arenas, Carlos; Pelegrí-Sisó, Dolors; Casas Sanahuja, Maribel; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Urquiza, José M.; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Estivill, Xavier, 1955-; González, Juan Ramón; Vrijheid, Martine (Nature Research, 2022)
    Environmental exposures during early life play a critical role in life-course health, yet the molecular phenotypes underlying environmental effects on health are poorly understood. In the Human Early Life Exposome (HELIX) ...
  • Multicenter experiment for quality control of peptide-centric LC-MS/MS analysis - A longitudinal performance assessment with nLC coupled to orbitrap MS analyzers
    Campos, Alex; Díaz, Ramón; Martínez Bartolomé, Salvador; Sierra, Jose; Gallardo, Oscar; Sabidó Aguadé, Eduard, 1981-; López Lucendo, María; Casal, José Ignacio; Pasquarello, Carla; Scherl, Alexander; Chiva, Cristina; Borrás, Eva; Odena, Antonia; Elortza, Félix; Azkargorta, Mikel; Ibarrola, Nieves; Canals, Francesc; Albar, Juan Pablo; Oliveira, Eliandre (Elsevier, 2015)
    Proteomic technologies based on mass spectrometry (MS) have greatly evolved in the past years, and nowadays it is possible to routinely identify thousands of peptides from complex biological samples in a single LC-MS/MS ...
  • Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage
    Casas, Caty; Isús Díaz, Laura, 1989-; Herrando Grabulosa, Mireia; Mancuso, Francesco M.; Borrás, Eva; Sabidó Aguadé, Eduard, 1981-; Forés, Joaquim; Aloy, Patrick, 1972- (Nature Publishing Group, 2015)
    Neurodegenerative processes are preceded by neuronal dysfunction and synaptic disconnection. Disconnection between spinal motoneuron (MN) soma and synaptic target leads either to a retrograde degenerative process or to a ...
  • Origins of de novo genes in human and chimpanzee
    Ruiz Orera, Jorge, 1988-; Hernández Rodríguez, Jéssica, 1983-; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Kondova, Ivanela; Bontrop, Ronald E.; Marquès i Bonet, Tomàs, 1975-; Albà Soler, Mar (Public Library of Science, 2015)
    The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these ...
  • Peptide selection for targeted protein quantitation
    Chiva, Cristina; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2017)
    Targeted proteomics methods in their different flavors rely on the use of a few peptides as proxies for protein quantitation, which need to be specified either prior to or after data acquisition. However, in contrast with ...

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