Browsing by Author "Roquer, Jaume"

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  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
    Min, Josine L.; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Ruiz Arenas, Carlos, 1990-; Jiménez Conde, Jordi; Roquer, Jaume; González, Juan Ramón; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Relton, Caroline (Nature Research, 2021)
    Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait ...
  • Glycated hemoglobin value combined with initial glucose levels for evaluating mortality risk in patients with ischemic stroke.
    Roquer, Jaume; Giralt-Steinhauer, Eva; Cerdà, Georgina; Rodríguez Campello, Ana María; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Vivanco Hidalgo, Rosa María; Soriano Tarraga, Carolina; Roman Degano, Irene; Ois Santiago, Angel Javier (Karger, 2015)
    BACKGROUND: Hyperglycemia is a marker of poor outcome in acute ischemic stroke (IS) patients. We aimed at evaluating the effect of combined HbA1c and first glucose measurement values on 3-month mortality prediction. METHODS: ...
  • Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.
    Sayols, Sergi; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Civeira, Fernando; Roquer, Jaume; Do, AN; Absher, Devin; Cenarro, A.; Muñoz, Dani; Soriano Tarraga, Carolina; Jiménez Conde, Jordi; Ordovás, José M.; Sentí Clapés, Mariano; Aslibekyan, Stella W.; Marrugat de la Iglesia, Jaume; Arnett, Donna K.; Elosua Llanos, Roberto (Oxford University Press, 2016)
    Lipid traits (total, low-densityand high-density lipoproteincholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is an inherited but also modifiable epigenetic mark ...
  • Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study.
    Sayols, Sergi; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Lucas A.; Vilahur Chiaraviglio, Nadia, 1982-; Corella, Dolores; Muñoz, Dani; Segura, Antoni, 1952-; Jiménez Conde, Jordi; Moran, Sebastian; Soriano Tarraga, Carolina; Roquer, Jaume; Lopez-Farré, Antonio; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Taylor & Francis, 2015)
    Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at ...
  • Impact of COVID-19 on hospital admissions and healthcare quality indicators in non-COVID patients: a retrospective study of the first COVID-19 year in a university hospital in Spain
    Domingo, Laia; Comas Serrano, Mercè; Jansana Riera, Anna; Louro, Javier; Tizón-Marcos, Helena; Cos, Maria Lourdes; Roquer, Jaume; Chillarón Jordan, Juan José; Cirera Lorenzo, Isabel; Pascual Guàrdia, Sergi, 1979-; Sala, Maria; Castells, Xavier (MDPI, 2022)
    Few studies have assessed the impact of the COVID-19 pandemic on non-COVID diseases and healthcare quality. We aimed to evaluate changes in rates of hospitalisations, complications, in-hospital mortality, and readmissions ...
  • Inflammatory response of ischemic tolerance in circulating plasma: preconditioning-induced by transient ischemic attack (TIA) phenomena in acute ischemia patients (AIS)
    Colàs-Campàs, Laura; Farré, Joan; Mauri-Capdevila, Gerard; Molina-Seguín, Jessica; Aymerich, Núria; Ois Santiago, Angel Javier; Roquer, Jaume; Tur, Silvia; García-Carreira, María Del Carmen; Martí-Fàbregas, Joan; Cruz-Culebras, Antonio; Segura, Tomás; Arqué, Gloria; Purroy, Francisco (Frontiers, 2020)
    Introduction: Ischemic tolerance (IT) refers to a state where cells are resistant to the damaging effects caused by periods of ischemia. In a clinical scenario, the IT phenomenon would be activated by a recent transient ...
  • Interaction of sex and diabetes on outcome after ischemic stroke
    Soriano Reixach, Maria Montserrat; Vivanco Hidalgo, Rosa María; Ois Santiago, Angel Javier; Rodríguez-Campello, Ana; Roquer, Jaume (Frontiers, 2018)
    BACKGROUND: The relationship between ischemic stroke (IS), diabetes mellitus (DM), and sex is intriguing. The aim of this study was to assess the effect modification of sex in the association between DM and short- and ...
  • Ischemic stroke patients are biologically older than their chronological age.
    Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Mola Caminal, Marina; Vivanco Hidalgo, Rosa María; Ois Santiago, Angel Javier; Rodríguez‐Campello, Ana; Cuadrado-Godia, Elisa; Sayols, Sergi; Elosua Llanos, Roberto; Roquer, Jaume; Jiménez‐Conde, Jordi ( Impact Journals, 2016)
    Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference ...
  • Long-term cardiovascular prognosis after transient ischemic attack: Associated predictors
    Ois Santiago, Angel Javier; Zabalza, Ana; Moreira Villanueva, Antía; Cuadrado-Godia, Elisa; Jiménez Conde, Jordi; Giralt-Steinhauer, Eva; Rodríguez Campello, Ana María; Soriano Tarraga, Carolina; Roquer, Jaume (Lippincott Williams & Wilkins, 2018)
    OBJECTIVE: To determine long-term cardiovascular risk after TIA and to identify the factors associated with increased risk. METHODS: This was a prospective observational registry of TIA patients admitted to the emergency ...
  • Long-term stroke recurrence after transient ischemic attack: implications of etiology
    Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Giralt-Steinhauer, Eva; Jiménez Conde, Jordi; Soriano Tarraga, Carolina; Rodríguez Campello, Ana María; Avellaneda Gómez, Carla; Cascales Lahoz, Diego; Fernández-Pérez, Isabel; Roquer, Jaume (Korean Stroke Society, 2019)
    Background and purpose: To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification. Methods: A prospective cohort of 706 TIA patients ...
  • Misdiagnosis worsens prognosis in subarachnoid hemorrhage with good hunt and hess score
    Ois Santiago, Angel Javier; Vivas, Elio; Figueras-Aguirre, Georgina; Guimaraens, Leopoldo; Cuadrado-Godia, Elisa; Avellaneda Gómez, Carla; Bertran-Recasens, Bernat; Rodríguez-Campello, Ana; Gracia Arnillas, María Pilar; Villalba Martínez, Gloria; Saldaña, Jesus; Capellades Font, Jaume; Fernández-Candil, Juan-Luis; Roquer, Jaume (Lippincott Williams & Wilkins, 2019)
    Background and Purpose- Our aim was to describe variables associated with initial misdiagnosis of subarachnoid hemorrhage (SAH). We also analyzed the relationship of misdiagnosis with poor outcome and complications in good ...
  • Nitro-oxidative stress after neuronal ischemia induces protein nitrotyrosination and cell death
    Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Pérez Asensio, Fernando; Reyes Navarro, Mario; Caballo, Carolina; Galán, Ana M.; Alameda Quitllet, Francisco; Escolar, Ginès; Opazo, Carlos M.; Planas, Anna; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Hindawi, 2013)
    Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and brain vessel cells. Immediately after the stroke, the ischemic ...
  • Outcome after acute ischemic stroke is linked to sex-specific lesion patterns
    Bonkhoff, Anna K.; Jimenez-Conde, Jordi; Roquer, Jaume; Rost, Natalia (Nature Research, 2021)
    Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions ...
  • Prevalence of cardiovascular risk factors in people with epilepsy
    Vivanco Hidalgo, Rosa María; Gomez, Alejandra; Moreira Villanueva, Antía; Díez, Laura; Elosua Llanos, Roberto; Roquer, Jaume (Wiley, 2016)
    OBJECTIVES: Epilepsy has been associated with cardiovascular comorbidity. This study aimed to assess the potential association between cardiovascular risk factors (CRFs), antiepileptic drugs (AEDs), and etiology. MATERIAL ...
  • Prevención de ictus en pacientes con diabetes mellitus tipo 2 o prediabetes. Recomendaciones del Grupo de Estudio de Enfermedades Cerebrovasculares de la Sociedad Española de Neurología
    Fuentes Gimeno, Blanca Eulalia; Amaro, S.; Alonso de Leciñana, M.; Arenillas, J.F.; Ayo-Martín, O.; Castellanos, M.; Freijo, M.M.; García Pastor, A.; Gomis,M.; Gómez Choco, M.; López-Cancio Martínez, E.; Martínez Sánchez, P.; Morales, A.; Palacio-Portilla, E.J.; Rodríguez-Yáñez, M.; Roquer, Jaume; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, J.; Spanish Society of Neurology's Cerebrovascular Disease Study Group (Elsevier, 2021)
    Objetivo: actualizar las recomendaciones de la Sociedad Española de Neurología para la prevención del ictus en pacientes con DM-2 o prediabetes, analizando las evidencias disponibles sobre el efecto del control metabólico ...
  • Recognition of air pollution as a risk factor for stroke in clinical practice guidelines: a literature review.
    Avellaneda Gómez, Carla; Roquer, Jaume; Vivanco Hidalgo, Rosa María (Elsevier, 2021)
  • Recommendations of the Spanish Society of Neurology for the prevention of stroke. Interventions on lifestyle and air pollution
    García Pastor, A.; López-Cancio Martínez, E.; Rodríguez-Yáñez, M.; Alonso de Leciñana, M.; Amaro, S.; Arenillas, J.F.; Ayo-Martín, O.; Castellanos, M.; Fuentes Gimeno, Blanca Eulalia; Freijo, M.M.; Gomis, M.; Gómez Choco, M.; Martínez Sánchez, P.; Morales, A.; Palacio-Portilla, E.J.; Segura, Tomás; Serena, Joaquín; Vivancos-Mora, J.; Roquer, Jaume; Spanish Society of Neurology's Cerebrovascular Disease Study Group (Elsevier, 2021)
    Objective: to update the recommendations of the Spanish Society of Neurology regarding lifestyle interventions for stroke prevention. Development: We reviewed the most recent studies related to lifestyle and stroke risk, ...
  • Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort
    Medrano-Martorell, Santiago; Capellades Font, Jaume; Jiménez-Conde, Jordi; González-Ortiz, Sofía; Vilas-González, Marta; Rodríguez-Campello, Ana; Ois Santiago, Angel Javier; Cuadrado-Godia, Elisa; Avellaneda Gómez, Carla; Fernández, Isabel; Merino-Peña, Elisa; Roquer, Jaume; Martí-Fàbregas, Joan; Giralt-Steinhauer, Eva (Springer, 2022)
    Objectives: The spectrum of distribution of white matter hyperintensities (WMH) may reflect different functional, histopathological, and etiological features. We examined the relationships between cerebrovascular risk ...
  • RP11-362K2.2:RP11-767I20.1 Genetic variation is associated with post-reperfusion therapy parenchymal hematoma. A GWAS meta-analysis
    Muiño, Elena; Jiménez-Conde, Jordi; Roquer, Jaume; Giralt-Steinhauer, Eva; Soriano Tarraga, Carolina; The Spanish Stroke Genetic Consortium (MDPI, 2021)
    Stroke is one of the most common causes of death and disability. Reperfusion therapies are the only treatment available during the acute phase of stroke. Due to recent clinical trials, these therapies may increase their ...
  • Satisfaction with oral anticoagulants in patients with atrial fibrillation
    Suárez Fernández, Carmen; Castilla-Guerra, Luis; Cantero Hinojosa, Jesus; Suriñach, Josep Maria; Acosta de Bilbao, Fernando; Tamarit, Juan José; Diaz Diaz, José Luis; Hernández, Jose Luis; Pose, Antonio; Montero-Pérez-Barquero, Manuel; Roquer, Jaume; Gállego, Jaime; Vivancos, José; Mostaza, José María (Dove Medical Press, 2018)
    BACKGROUND: Although, by itself, atrial fibrillation is associated with an impairment of quality of life antithrombotic therapy may play a role. OBJECTIVE: To evaluate the satisfaction with anticoagulant treatment in ...