Browsing by Author "Piñero González, Janet, 1977-"

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  • Piñero González, Janet, 1977-; Gonzalez-Perez, Abel; Guney, Emre; Aguirre Plans, Joaquim, 1993-; Sanz, Ferran; Oliva Miguel, Baldomero; Furlong, Laura I., 1971- (Frontiers, 2018)
    Understanding the mechanisms underlying drug therapeutic action and toxicity is crucial for the prevention and management of drug adverse reactions, and paves the way for a more efficient and rational drug design. The ...
  • Gualdi, Francesco; Oliva Miguel, Baldomero; Piñero González, Janet, 1977- (Oxford University Press, 2024)
    Knowledge graph embeddings (KGE) are a powerful technique used in the biomedical domain to represent biological knowledge in a low dimensional space. However, a deep understanding of these methods is still missing, and, ...
  • Aguirre Plans, Joaquim, 1993-; Piñero González, Janet, 1977-; Menche, Jörg; Sanz, Ferran; Furlong, Laura I., 1971-; Schmidt, Harald H.H.W.; Oliva Miguel, Baldomero; Guney, Emre (MDPI, 2018)
    The past decades have witnessed a paradigm shift from the traditional drug discovery shaped around the idea of “one target, one disease” to polypharmacology (multiple targets, one disease). Given the lack of ...
  • Gutiérrez Sacristán, Alba; Grosdidier, Solène; Valverde Granados, Olga; Torrens, Marta; Bravo Serrano, Àlex, 1984-; Piñero González, Janet, 1977-; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2015)
    PsyGeNET (Psychiatric disorders and Genes association NETwork) is a knowledge platform for the exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of a database and a web interface ...
  • Pérez-Granado, Judith; Piñero González, Janet, 1977-; Furlong, Laura I., 1971- (Oxford University Press, 2019)
    The clinical efficacy of therapeutic monoclonal antibodies for breast and colorectal cancer has greatly contributed to the improvement of patients' outcomes by individualizing their treatments according to their genomic ...
  • Campos Mata, Leire de, 1991-; Tejedor Vaquero, Sonia, 1988-; Tachó-Piñot, Roser; Piñero González, Janet, 1977-; Grasset, Emilie K.; Arrieta Aldea, Itziar; Rodrigo Melero, Natalia; Carolis, Carlo; Horcajada Gallego, Juan Pablo; Cerutti, Andrea, 1965-; Villar García, Judit; Magri, Giuliana, 1978- (Wiley Open Access, 2021)
    Objectives: SARS-CoV-2 infection induces virus-reactive memory B cells expressing unmutated antibodies, which hints at their emergence from naïve B cells. Yet, the dynamics of virus-specific naïve B cells and their impact ...
  • Piñero González, Janet, 1977-; Saüch Pitarch, Josep; Sanz, Ferran; Furlong, Laura I., 1971- (Elsevier, 2021)
    Thanks to the unbiased exploration of genomic variants at large scale, hundreds of thousands of disease-associated loci have been uncovered. In parallel, network-based approaches have proven to be essential to understand ...
  • Piñero González, Janet, 1977-; Ramírez Anguita, Juan Manuel; Saüch Pitarch, Josep; Ronzano, Francesco; Centeno, Emilio; Sanz, Ferran; Furlong, Laura I., 1971- (Oxford University Press, 2020)
    One of the most pressing challenges in genomic medicine is to understand the role played by genetic variation in health and disease. Thanks to the exploration of genomic variants at large scale, hundreds of thousands of ...
  • Salgado, David; Beltran, Sergi; Furlong, Laura I., 1971-; Gut, Ivo Glynne; Laurie, Steven, 1973-; Marquès i Bonet, Tomàs, 1975-; Piñero González, Janet, 1977-; Sanz, Ferran; Béroud, Christophe (F1000Research, 2020)
    Copy number variations (CNVs) are major causative contributors both in the genesis of genetic diseases and human neoplasias. While "High-Throughput" sequencing technologies are increasingly becoming the primary choice for ...
  • Pognan, François; Centeno, Emilio; Furlong, Laura I., 1971-; Guney, Emre; Mayer, Miguel Ángel, 1960-; Pastor Maeso, Manuel; Piñero González, Janet, 1977-; Ramírez Anguita, Juan Manuel; Ronzano, Francesco; Saüch Pitarch, Josep; Sanz, Ferran (MDPI, 2021)
    eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety ...
  • Callegaro, Giulia; Kunnen, Steven J.; Trairatphisan, Panuwat; Grosdidier, Solène; Niemeijer, Marije; den Hollander, Wouter; Guney, Emre; Piñero González, Janet, 1977-; Furlong, Laura I., 1971-; Webster, Yue W.; Saez-Rodriguez, Julio; Sutherland, Jeffrey J.; Mollon, Jennifer; Stevens, James L.; van de Water, Bob (SpringerOpen, 2021)
    Mechanism-based risk assessment is urged to advance and fully permeate into current safety assessment practices, possibly at early phases of drug safety testing. Toxicogenomics is a promising source of mechanisms-revealing ...
  • Piñero González, Janet, 1977-; Berenstein, Ariel José; González-Pérez, Abel; Chernomoretz, Ariel; Furlong, Laura I., 1971- (Nature Publishing group, 2016)
    Characterizing the behavior of disease genes in the context of biological networks has the potential to shed light on disease mechanisms, and to reveal both new candidate disease genes and therapeutic targets. Previous ...

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