Browsing by Author "Navarro Medrano, Pilar"

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  • Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk
    Orozco, Carlos Alberto; Martínez Bosch, Neus; Enrique Guerrero, Pedro; Vinaixa Forner, Judith, 1991-; Dalotto-Moreno, Tomás; Iglesias García, Mar; Moreno, Mireia; Djurec, Magdolna; Poirier, Françoise; Gabius, Hans J.; Fernández-Zapico, Martin E.; Hwang, Rosa F.; Guerra, Carmen; Rabinovich, Gabriel A.; Navarro Medrano, Pilar (National Academy of Sciences, 2018)
    Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely low survival rates due to late diagnosis and resistance to standard therapies. A more comprehensive understanding of the ...
  • The Galectin family as molecular targets: hopes for defeating pancreatic cancer
    Manero Rupérez, Noemí; Martínez Bosch, Neus; Barranco Priego, Luis Eugenio; Visa Turmo, Laura; Navarro Medrano, Pilar (MDPI, 2020)
    Galectins are a family of proteins that bind β-galactose residues through a highly conserved carbohydrate recognition domain. They regulate several important biological functions, including cell proliferation, adhesion, ...
  • The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer.
    Martínez Bosch, Neus; Enrique Guerrero, Pedro; Moreno, Mireia; José Segarra-Martínez, Anabel; Iglesias García, Mar; Munné-Collado, Jessica; Anta Rodríguez, Héctor, 1988-; Gibert, Joan; Orozco, Carlos Alberto; Vinaixa Forner, Judith, 1991-; Fillat i Fonts, Cristina; Viñals, Francesc; Navarro Medrano, Pilar (Impact Journals, 2016)
    Current treatments for pancreatic ductal adenocarcinoma (PDA) are ineffective, making this the 4th leading cause of cancer deaths. Sunitinib is a broad-spectrum inhibitor of tyrosine kinase receptors mostly known for its ...
  • Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies
    Villanueva, Eneko; Navarro Medrano, Pilar; Rovira-Rigau, Maria; Sibilio, Annarita; Méndez Giraldez, Raúl; Fillat i Fonts, Cristina (Nature Publishing Group, 2017)
    Systemic treatment of cancer requires tumour-selective therapies that eliminate cancer cells yet preserve healthy tissues from undesired damage. Tumoral transformation is associated with profound effects in translational ...

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