Browsing by Author "Nadal Clanchet, Eulàlia de"

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  • LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions
    Serra, Selma A.; Stojakovic, Predrag; Amat, Ramon; Rubio Moscardó, Fanny; Latorre Doménech, Pablo, 1993-; Seisenbacher, Gerhard; Canadell, David; Böttcher, René; Aregger, Michael; Moffat, Jason; Nadal Clanchet, Eulàlia de; Valverde, M. A. (Miguel Ángel), 1963-; Posas Garriga, Francesc (National Academy of Sciences, 2021)
    Regulation of cell volume is essential for tissue homeostasis and cell viability. In response to hypertonic stress, cells need rapid electrolyte influx to compensate water loss and to prevent cell death in a process known ...
  • Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
    Duch, Alba; Canal de Torres, Berta, 1988-; Barroso, Sonia I.; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera, Andrés; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Nature Publishing Group, 2018)
    Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope ...
  • A novel role for lncRNAs in cell cycle control during stress adaptation
    Solé, Carme; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Springer, 2015)
    Eukaryotic cells have developed sophisticated systems to constantly monitor changes in the extracellular environment and to orchestrate a proper cellular response. To maximize survival, cells delay cell-cycle progression ...
  • Osmostress-induced gene expression--a model to understand how stress-activated protein kinases (SAPKs) regulate transcription
    Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Wiley, 2015)
    Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are ...
  • Phosphorylation and proteasome recognition of the mRNA-Binding protein Cth2 facilitates yeast adaptation to iron deficiency
    Romero, Antonia M.; Martínez Pastor, Mar; Du, Gang; Solé, Carme; Carlos, María; Vergara, Sandra V.; Sanvisens, Nerea; Wohlschlegel, James A.; Toczyski, David P.; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Martínez-Pastor, María T.; Thiele, Dennis J.; Puig, Sergi (American Society for Microbiology, 2018)
    Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the ...
  • Positive feedback induces switch between distributive and processive phosphorylation of Hog1
    Mosbacher, Maximilian; Lee, Sung Sik; Yaakov, Gilad; Nadal Ribelles, Mariona, 1984-; Nadal Clanchet, Eulàlia de; van Drogen, Frank; Posas Garriga, Francesc; Peter, Matthias; Claassen, Manfred (Nature Research, 2023)
    Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ...
  • Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock
    Amat, Ramon; Böttcher, René; Le Dily, François; Vidal Ocabo, Enrique; Quilez Oliete, Javier; Cuartero, Yasmina; Beato, Miguel; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    Nuclear architecture is decisive for the assembly of transcriptional responses. However, how chromosome organization is dynamically modulated to permit rapid and transient transcriptional changes in response to environmental ...
  • Regulation of alternative splicing by the p38 SAPK in response to stress
    Carbonell Núñez, Caterina, 1987- (Universitat Pompeu Fabra, 2018-12-20)
    Cells have the ability to respond and adapt to environmental changes through activation of stress-activated protein kinases (SAPKs). Activation of the p38 SAPK is critical to elicit the early gene expression program required ...
  • Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage
    Ulsamer, Arnau; Martínez Limón, Adrián; Bader, Sina; Rodríguez-Acebes, Sara; Freire, Raimundo; Méndez, Juan; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2022)
    Stress-activated protein kinases (SAPKs) enhance survival in response to environmental changes. In yeast, the Hog1 SAPK and Mrc1, a protein required for DNA replication, define a safeguard mechanism that allows eukaryotic ...
  • Regulation of transcription elongation in response to osmostress
    Silva, Andrea; Cavero, Santiago; Begley, Victoria; Solé, Carme; Böttcher, René; Chávez, Sebastián; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Public Library of Science (PLoS), 2017)
    Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell ...
  • Regulation of transcriptional activation in response to heat stress and osmostress
    Ruiz Roig, Clàudia (Universitat Pompeu Fabra, 2011-12-02)
    A Saccharomyces cerevisiae, un increment de la temperatura comporta diversos efectes deleteris en l’organització interna de la cèl∙lula i indueix una inducció ràpida, massiva i transitòria d’expressió gènica, que es controla ...
  • Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program
    Jiménez, Carlos; Antonelli, Roberta; Nadal-Ribelles, Mariona; Devis-Jauregui, Laura; Latorre Doménech, Pablo, 1993-; Solé, Carme; Masanas, Marc; Molero-Valenzuela, Adrià; Soriano, Aroa; Sánchez de Toledo, Josep; Llobet-Navas, David; Roma, Josep; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de; Gallego, Soledad; Moreno, Lucas; Segura, Miguel F. (BioMed Central, 2022)
    Background: Epigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the initiation of embryonal tumour development. In neuroblastoma, neural ...
  • The HOG pathway and the regulation of osmoadaptive responses in yeast
    Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Oxford University Press, 2022)
    Cells coordinate intracellular activities in response to changes in the extracellular environment to maximize their probability of survival and proliferation. Eukaryotic cells need to adapt to constant changes in the ...
  • The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms
    Ruiz Roig, Clàudia; Noriega Esteban, Núria; Duch, Alba; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (American Society for Cell Biology, 2012)
    Cells modulate expression of nuclear genes in response to alterations in mitochondrial function, a response termed retrograde (RTG) regulation. In budding yeast, the RTG pathway relies on Rtg1 and Rtg3 basic helix-loop-helix ...
  • The Hog1p kinase regulates Aft1p transcription factor to control iron accumulation
    Martins, Telma S.; Pereira, Clara; Canadell, David; Vilaça, Rita; Teixeira, Vítor; Moradas Ferreira, Pedro; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc; Costa, Vítor M.V. (Elsevier, 2018)
    Iron acquisition systems have to be tightly regulated to assure a continuous supply of iron, since it is essential for survival, but simultaneously to prevent iron overload that is toxic to the cells. In budding yeast, the ...
  • The p38 pathway: from biology to cancer therapy
    Martínez Limón, Adrián; Joaquin i Caudet, Manel; Caballero, María; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (MDPI, 2020)
    The p38 MAPK pathway is well known for its role in transducing stress signals from the environment. Many key players and regulatory mechanisms of this signaling cascade have been described to some extent. Nevertheless, p38 ...
  • The p57 CDKi integrates stress signals into cell-cycle progression to promote cell survival upon stress
    Joaquin i Caudet, Manel; Gubern, Albert; González Nuñez, Daniel; Ruiz, E. Josué; Ferreiro Neira, Isabel; Nadal Clanchet, Eulàlia de; Nebreda, Ángel R.; Posas Garriga, Francesc (Nature Publishing Group, 2012)
    The p57(Kip2) cyclin-dependent kinase inhibitor (CDKi) has been implicated in embryogenesis, stem-cell senescence and pathologies, but little is known of its role in cell cycle control. Here, we show that p57(Kip2) is ...
  • The regulation of Net1/Cdc14 by the Hog1 MAPK upon osmostress unravels a new mechanism regulating mitosis
    Jiménez, Javier; Queralt Badia, Ethel; Posas Garriga, Francesc; Nadal Clanchet, Eulàlia de (Taylor & Francis, 2020)
    During evolution, cells have developed a plethora of mechanisms to optimize survival in a changing and unpredictable environment. In this regard, they have evolved networks that include environmental sensors, signaling ...
  • The Role of histone modifications in transcriptional regulation upon stress
    Viéitez Manrique, Cristina, 1984- (Universitat Pompeu Fabra, 2016-05-19)
    In response to fluctuations in the environment, all living organisms have the ability to sense, respond and adapt to the new conditions. In budding yeast (Saccharomyces cerevisiae) there is a massive and rapid reorganization ...
  • The Role of the LRRC8A anion channel in adaptation to stress
    Stojakovic, Predrag (Universitat Pompeu Fabra, 2023-03-10)
    Cell volume regulation is essential for cellular homeostasis and adaptation to environmental osmotic changes. Upon hyperosmotic stress, cells need to rapidly restore osmotic balances in order to preserve the function of ...