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Browsing by Author "Muñoz López, Francisco José, 1964-"

Browsing by Author "Muñoz López, Francisco José, 1964-"

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  • Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Guix Ràfols, Francesc Xavier; Clarimón Echevarría, Jordi; Miscione, Gian Pietro; Boada, Mercè; Gil Gómez, Gabriel; Suzuki, Toshiharu; Molina, Henrik; Villà i Freixa, Jordi; Vicente García, Rubén, 1978-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Amyloid-β peptide (Aβ) aggregates induce nitro-oxidative stress, contributing to the characteristic neurodegeneration found in Alzheimer's disease (AD). One of the most strongly nitrotyrosinated proteins in AD is the ...
  • Tajes Orduña, Marta; Eraso Pichot, Abel; Rubio Moscardó, Fanny; Guivernau Almazán, Biuse, 1988-; Bosch Morató, Mònica, 1986-; Valls Comamala, Victòria, 1987-; Miscione, Gian Pietro; Villà i Freixa, Jordi; Suzuki, Toshiharu; Muñoz López, Francisco José, 1964- (Elsevier, 2014)
    Alzheimer's disease (AD) is characterized by the oxidative stress generated from amyloid β-peptide (Aβ) aggregates. It produces protein nitrotyrosination, after the reaction with nitric oxide to form peroxynitrite, being ...
  • Godoy Zeballos, Juan Alejandro, 1959-; Rios, Juvenal A.; Picón-Pagès, Pol; Herrera-Fernández, Víctor; Swaby, Bronte; Crepin, Giulia; Vicente García, Rubén, 1978-; Fernández-Fernández, José Manuel, 1967-; Muñoz López, Francisco José, 1964- (MDPI, 2021)
    Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic plasticity. Their functional integrity is ...
  • Guix Ràfols, Francesc Xavier; Wahle, Tina; Vennekens, Kristel; Snellinx, An; Chávez Gutiérrez, Lucía; Ill-Raga, Gerard, 1982-; Ramos Fernández, Eva, 1984-; Guardia Laguarta, Cristina; Lleó, Alberto; Arimon, Muriel; Berezovska, Oksana; Muñoz López, Francisco José, 1964-; Dotti, Carlos G.; De Strooper, Bart (Wiley-VCH Verlag, 2012)
    Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known ...
  • Hammouda, Souha; Ghzaiel, Imen; Picón-Pagès, Pol; Meddeb, Wiem; Khamlaoui, Wided; Hammami, Sonia; Muñoz López, Francisco José, 1964-; Hammami, Mohamed; Zarrouk, Amira (MDPI, 2021)
    Oxysterols are assumed to be the driving force behind numerous neurodegenerative diseases. In this work, we aimed to study the ability of 7β-hydroxycholesterol (7β-OHC) to trigger oxidative stress and cell death in human ...
  • Tajes Orduña, Marta; Ill-Raga, Gerard, 1982-; Palomer, Ernest; Ramos Fernández, Eva, 1984-; Guix Ràfols, Francesc Xavier; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Jiménez Conde, Jordi; Ois Santiago, Angel Javier; Pérez Asensio, Fernando; Reyes Navarro, Mario; Caballo, Carolina; Galán, Ana M.; Alameda Quitllet, Francisco; Escolar, Ginès; Opazo, Carlos M.; Planas, Anna; Roquer, Jaume; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Hindawi, 2013)
    Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and brain vessel cells. Immediately after the stroke, the ischemic ...
  • Coma Camprodón, Mireia; Guix Ràfols, Francesc Xavier; Ill-Raga, Gerard, 1982-; Uribesalgo Micàs, Iris; Alameda Quitllet, Francisco; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (Elsevier, 2008)
    Cerebral amyloid angiopathy, associated to most cases of Alzheimer's disease (AD), is characterized by the deposition of amyloid ss-peptide (Ass) in brain vessels, although the origin of the vascular amyloid deposits is ...
  • Ill-Raga, Gerard, 1982-; Tajes Orduña, Marta; Busquets Garcia, Arnau, 1985-; Ramos Fernández, Eva, 1984-; Vargas, Lina M.; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Valls Comamala, Victòria, 1987-; Eraso Pichot, Abel; Guix Ràfols, Francesc Xavier; Fandos, César; Rosen, Mark D.; Rabinowitz, Michael H.; Maldonado, Rafael, 1961-; Álvarez, Alejandra R.; Ozaita Mintegui, Andrés, 1969-; Muñoz López, Francisco José, 1964- (Mary Ann Liebert, Inc, 2015)
    AIMS: Hippocampus is the brain center for memory formation, a process that requires synaptogenesis. However, hippocampus is dramatically compromised in Alzheimer's disease due to the accumulation of amyloid β-peptide, whose ...
  • Palomer, Ernest; Ill-Raga, Gerard, 1982-; Tajes Orduña, Marta; Ramos Fernández, Eva, 1984-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Galán, José J; Clarimón Echevarría, Jordi; Antúnez, Carmen; Boada, Mercè; Real, Luis M; Fandos, César; Muñoz López, Francisco José, 1964- (Scientific Research Publishing, 2011)
    Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ß-peptide (Aß) produced by the cleavage of a transmembrane protein ...
  • Ramos Fernández, Eva, 1984-; Tajes Orduña, Marta; Palomer, Ernest; Ill-Raga, Gerard, 1982-; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Roman Degano, Irene; Eraso Pichot, Abel; Alcolea, Daniel; Fortea, Juan; Núñez, Laura; Páez, Antonio; Alameda Quitllet, Francisco; Fernàndez Busquets, Xavier; Lleó, Alberto; Elosua Llanos, Roberto; Boada, Mercè; Valverde, M. A. (Miguel Ángel), 1963-; Muñoz López, Francisco José, 1964- (IOS Press, 2014)
    Glycation and nitrotyrosination are pathological posttranslational modifications that make proteins prone to losing their physiological properties. Since both modifications are increased in Alzheimer's disease (AD) due to ...
  • Rubio Moscardó, Fanny; Bosch Morató, Mònica, 1986-; Plata, Cristina; Gené, Gemma; Muñoz López, Francisco José, 1964-; Valverde, M. A. (Miguel Ángel), 1963-; Clarimón Echevarría, Jordi (Public Library of Science (PLoS), 2013)
    Calcium signaling in the brain is fundamental to the learning and memory process and there is evidence to suggest that its dysfunction is involved in the pathological pathways underlying Alzheimer’s disease (AD). Recently, ...
  • Álvarez, Alejandra R.; Alarcón Martínez, Rodrigo; Opazo, Carlos M.; Campos, Eliseo O.; Muñoz López, Francisco José, 1964-; Calderón, Frances H.; Dajas, Federico; Gentry, Mary K.; Doctor, Bhupendra P.; Mello, Fernando G. de; Inestrosa, Nibaldo C. (Society for Neuroscience, 1998)
    Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (Abeta) during its assembly into filaments, in agreement with its colocalization with the Abeta deposits of Alzheimer's brain. The association ...
  • Valls Comamala, Victòria, 1987-; Guivernau Almazán, Biuse, 1988-; Bonet Martínez, Jaume, 1982-; Puig, Marta; Perálvarez Marín, Alex; Palomer, Ernest; Fernàndez Busquets, Xavier; Altafaj, Xavier; Tajes Orduña, Marta; Puig Pijoan, Albert; Vicente García, Rubén, 1978-; Oliva Miguel, Baldomero; Muñoz López, Francisco José, 1964- (Impact Journals, 2017)
    The amyloid beta-peptide (Aβ) plays a leading role in Alzheimer's disease (AD) physiopathology. Even though monomeric forms of Aβ are harmless to cells, Aβ can aggregate into β-sheet oligomers and fibrils, which are both ...
  • Tajes Orduña, Marta; Ramos Fernández, Eva, 1984-; Weng-Jiang, Xian; Bosch Morató, Mònica, 1986-; Guivernau Almazán, Biuse, 1988-; Eraso Pichot, Abel; Salvador, Bertrán; Fernàndez Busquets, Xavier; Roquer, Jaume; Muñoz López, Francisco José, 1964- (Taylor & Francis (Routledge), 2014)
    The blood-brain barrier (BBB) is constituted by a specialized vascular endothelium that interacts directly with astrocytes, neurons and pericytes. It protects the brain from the molecules of the systemic circulation but ...
  • Vicario Orri, Elena, 1989-; Opazo, Carlos M.; Muñoz López, Francisco José, 1964- (IOS Press, 2015)
    Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of axons and axon terminals relies on the transport of proteins, ...
  • Bellot, Alba; Guivernau Almazán, Biuse, 1988-; Tajes Orduña, Marta; Bosch Morató, Mònica, 1986-; Valls Comamala, Victòria, 1987-; Muñoz López, Francisco José, 1964- (Elsevier, 2014)
    Dendritic spines are actin-rich protrusions from the dendritic shaft, considered to be the locus where most synapses occur, as they receive the vast majority of excitatory connections in the central nervous system (CNS). ...
  • Muñoz López, Francisco José, 1964-; Opazo, Carlos M.; Gil Gómez, Gabriel; Tapia, Gladys; Fernández, Virginia; Valverde, M. A. (Miguel Ángel), 1963-; Inestrosa, Nibaldo C. (Society for Neuroscience, 2002)
    Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...
  • Marín, Tamara; Contreras, Pablo; Castro, Juan Francisco; Chamorro, David; Balboa, Elisa; Bosch Morató, Mònica, 1986-; Muñoz López, Francisco José, 1964-; Álvarez, Alejandra R.; Zanlungo, Silvana (MDPI, 2014)
    Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. We have previously reported that oxidative stress is the main upstream stimulus activating ...
  • Parodi, Jorge; Montecinos Oliva, Carla; Varas, Rodrigo; Alfaro, Iván E.; Serrano, Felipe G.; Varas Godoy, Manuel; Muñoz López, Francisco José, 1964-; Cerpa, Waldo; Godoy Zeballos, Juan Alejandro, 1959-; Inestrosa, Nibaldo C. (Elsevier, 2015)
    Hippocampal synapses play a key role in memory and learning processes by inducing long-term potentiation and depression. Wnt signaling is essential in the development and maintenance of synapses via several mechanisms. We ...

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