Browsing by Author "Minguillón, Carolina"

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  • Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
    Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Minguillón, Carolina; Castro de Moura, Manuel; Piñeyro, David; Esteller, Manel; Molinuevo, José Luis; Guigó Serra, Roderic; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; ALFA Study (MDPI, 2021)
    This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and ...
  • Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study
    Rodríguez-Fernández, Blanca; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Operto, Grégory; Minguillón, Carolina; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Sala Vila, Aleix; ALFA Study (BioMed Central, 2022)
    Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes ...
  • Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
    Brugulat Serrat, Anna, 1986-; Rojas, Santiago; Bargallo, Nuria; Conesa Bertrán, Gerardo; Minguillón, Carolina; Fauria, Karine; Gramunt Fombuena, Nina; Molinuevo, José Luis; Domingo Gispert, Juan (BMJ Publishing Group, 2017)
    Objectives: To describe the prevalence of brain MRI incidental findings (IF) in a cohort of cognitively normal first-degree descendants of patients with Alzheimer's disease (AD). Design: Cross-sectional observational study. ...
  • Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected
    Suárez-Calvet, Marc; Milà Alomà, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Minguillón, Carolina; Shekari, Mahnaz; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Sala Vila, Aleix; González de Echávarri, José Maria; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was ...
  • Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Plasma and CSF biomarkers in a memory clinic: head-to-head comparison of phosphorylated tau immunoassays
    Ashton, Nicholas J.; Puig Pijoan, Albert; Milà Alomà, Marta; Fernández-Lebrero, Aida; Ortiz Romero, Paula, 1994-; Minguillón, Carolina; Navalpotro-Gómez, Irene; Grau-Rivera, Oriol; Manero, Rosa María; Puente Periz, Victor Manuel; Torre Fornell, Rafael de la; Roquer, Jaume; Suárez-Calvet, Marc (Wiley, 2023)
    Introduction: Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences. Methods: In the BIODEGMAR study, 197 participants presenting ...
  • Plasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer's disease
    Milà Alomà, Marta; Shekari, Mahnaz; Salvadó, Gemma; Ortiz Romero, Paula, 1994-; González-Escalante, Armand; Sánchez Benavides, Gonzalo; Minguillón, Carolina; Gispert López, Juan Domingo; Suárez-Calvet, Marc; Blennow, Kaj (Nature Research, 2022)
    Blood biomarkers indicating elevated amyloid-β (Aβ) pathology in preclinical Alzheimer's disease are needed to facilitate the initial screening process of participants in disease-modifying trials. Previous biofluid data ...
  • Prepandemic alzheimer disease biomarkers and anxious-depressive symptoms during the COVID-19 confinement in cognitively unimpaired adults
    Akinci, Muge; Peña-Gómez, Cleofé; Operto, Grégory; Fuentes-Julian, Sherezade; Deulofeu, Carme; Sánchez Benavides, Gonzalo; Milà Alomà, Marta; Grau-Rivera, Oriol; Gramunt Fombuena, Nina; Navarro i Cuartiellas, Arcadi, 1969-; Minguillón, Carolina; Fauria, Karine; Suridjan, Ivonne; Kollmorgen, Gwendlyn; Bayfield, Anna; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; Arenaza-Urquijo, Eider M.; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer disease (AD), which may accelerate disease progression. We investigated whether β-amyloid, cortical ...
  • Prevention of cognitive decline in subjective cognitive decline APOE ε4 carriers after EGCG and a multimodal intervention (PENSA): Study design
    Forcano, Laura; Fauria, Karine; Soldevila-Domenech, Natalia; Minguillón, Carolina; Lorenzo, Thais; Cuenca Royo, Aida Ma, 1981-; Menezes Cabral, Sofia; Pizarro Lozano, Mª Nieves; Boronat Rigol, Anna, 1990-; Molinuevo, José Luis; Torre Fornell, Rafael de la; PENSA Study Group (Wiley, 2021)
    Introduction: Subjects exhibiting subjective cognitive decline (SCD) are at an increased risk for mild cognitive impairment and dementia. Given the delay between risk exposure and disease onset, SCD individuals are ...
  • Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
    Sánchez Benavides, Gonzalo; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Milà Alomà, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Crous-Bou, Marta; Niñerola-Baizán, Aida; Perissinotti, Andrés; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) ...
  • Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Operto, Grégory; Falcón, Carles; Cacciaglia, Raffaele; Minguillón, Carolina; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (SpringerOpen, 2022)
    Purpose: glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid ...
  • Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
    Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...
  • The ALFA project: A research platform to identify early pathophysiological features of Alzheimer's disease
    Molinuevo, José Luis; Gramunt Fombuena, Nina; Domingo Gispert, Juan; Fauria, Karine; Esteller, Manel; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Huesa, Gema; Morán, Sebastián; Dal-Ré, Rafael; Camí, Jordi, 1952- (Elsevier, 2016)
    Introduction: The preclinical phase of Alzheimer's disease (AD) is optimal for identifying early pathophysiological events and developing prevention programs, which are shared aims of the ALFA project, including the ALFA ...
  • The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
    Salvadó, Gemma; Operto, Grégory; Cumplido-Mayoral, Irene; Arenaza Urquijo, Eider M.; Cacciaglia, Raffaele; Falcón, Carles; Vilor Tejedor, Natàlia, 1988-; Minguillón, Carolina; Gispert López, Juan Domingo; ADNI (Wiley, 2022)
    Introduction: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired ...
  • White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
    Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)
    White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...