Browsing by Author "Meyerhans, Andreas"

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  • Banks, H. Thomas; Kapraun, Dustin F.; Peligero Cruz, Cristina, 1986-; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Academic Publications, 2015)
    We carry out computational inverse problem investigations to determine the importance of allowing for unequal label allocation to daughter cells during mitosis. Parameter estimations are performed using previously developed ...
  • Bocharov, Gennady A.; Grebennikov, Dmitry; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Elsevier, 2021)
    A fundamental unsolved issue in vaccine design is how neutralizing antibodies and cytotoxic CD8+ T cells cooperate numerically in controlling virus infections. We hypothesize on a viewpoint for the multiplicative cooperativity ...
  • Bessonov, Nickolay; Bocharov, Gennady A.; Meyerhans, Andreas; Popov, Vladimir; Volpert, Vitaly (Society for Industrial and Applied Mathematics, 2021)
    In this work, we develop a mathematical framework for predicting and quantifying virus diversity evolution during infection of a host organism. It is specified as a virus density distribution with respect to genotype and ...
  • Martinez, Javier P.; Bocharov, Gennady A.; Ignatovich, Anna; Reiter, Jochen; Dittmar, Matthias T; Wain-Hobson, Simon; Meyerhans, Andreas (Public Library of Science (PLoS), 2011)
    Fitness interactions between mutations, referred to as epistasis, can strongly impact evolution. For RNA viruses and retroviruses with their high mutation rates, epistasis may be particularly important to overcome fitness ...
  • Bocharov, Gennady A.; Grebennikov, Dmitry; Cebollada Rica, Paula; Domenjó Vila, Eva, 1993-; Casella, Valentina, 1991-; Meyerhans, Andreas (Frontiers, 2022)
    The clinical handling of chronic virus infections remains a challenge. Here we describe recent progress in the understanding of virus - host interaction dynamics. Based on the systems biology concept of multi-stability and ...
  • Kobayashi-Ishihara, Mie; Terahara, Kazutaka; Martínez Vesga, Javier Pablo; Yamagishi, Makoto; Iwabuchi, Ryutaro; Brander, Christian; Ato, Manabu; Watanabe, Toshiki; Meyerhans, Andreas; Tsunetsugu-Yokota, Yasuko (Frontiers, 2018)
    Latently infected T lymphocytes are an important barrier toward eliminating a persistent HIV infection. Here we describe an HIV-based recombinant fluorescent-lentivirus referred to as “rfl-HIV” that enables to analyze sense ...
  • Tsunetsugu-Yokota, Yasuko; Kobayashi-Ishihara, Mie; Wada, Yamato; Terahara, Kazutaka; Takeyama, Haruko; Kawana-Tachikawa, Ai; Tokunaga, Kenzo; Yamagishi, Makoto; Martínez Vesga, Javier Pablo; Meyerhans, Andreas (Frontiers, 2016)
    Homeostatic proliferation (HSP) is a major mechanism by which long-lived naïve and memory CD4+ T cells are maintained in vivo and suggested to contribute to the persistence of the latent HIV-1 reservoir. However, while ...
  • Bouchnita, Anass; Bocharov, Gennady A.; Meyerhans, Andreas; Volpert, Vitaly (BioMed Central, 2017)
    BACKGROUND: Moving from the molecular and cellular level to a multi-scale systems understanding of immune responses requires the development of novel approaches to integrate knowledge and data from different biological ...
  • Martinez, Javier P.; Hinkelmann, Bettina; Fleta Soriano, Eric, 1983-; Steinmetz, Heinrich; Jansen, Rolf; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2013)
    Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development ...
  • Moros, Alexandra; Prenafeta, Antoni; Barreiro, Antonio; Perozo, Eva; Fernández, Alex; Cañete, Manuel; González, Luis; Garriga, Carme; Pradenas, Edwards; Marfil, Silvia; Blanco Arbués, Julià; Cebollada Rica, Paula; Sisteré-Oró, Marta; Meyerhans, Andreas; Prat Cabañas, Teresa; March, Ricard; Ferrer, Laura (Elsevier, 2023)
    The continuing high global incidence of COVID-19 and the undervaccinated status of billions of persons strongly motivate the development of a new generation of efficacious vaccines. We have developed an adjuvanted vaccine ...
  • Domenjó Vila, Eva (2022-06-08)
    The contribution of cross-presenting XCR1+ dendritic cells (DC) in maintaining T cell function during exhaustion and immuno-therapeutic interventions of chronic infections remains poorly characterized. Using the mouse model ...
  • Gomara, Maria J.; Pérez, Yolanda; Gómez Gutiérrez, Patrícia; Herrera, Carolina; Ziprin, Paul; Martínez, Javier P.; Meyerhans, Andreas; Pérez, Juan J.; Haro, Isabel (Nature Research, 2020)
    Based on the structure of an HIV-1 entry inhibitor peptide two stapled- and a retro-enantio peptides have been designed to provide novel prevention interventions against HIV transmission. The three peptides show greater ...
  • Herrmann, Madeleine; Ruprecht, Klemens; Sauter, Marlies; Martinez, Javier P.; van Heteren, Pearl; Glas, Michael; Best, Barbara; Meyerhans, Andreas; Roemer, Klaus; Mueller-Lantzsch, Nikolaus (Elsevier, 2010)
    Retrovirus replication critically depends on a dynamic interplay between retroviral and host proteins. We report on the binding of the surface subunit (glycoprotein 120 (gp120)) of the human immunodeficiency virus type 1 ...
  • Grebennikov, Dmitry; Kholodareva, Ekaterina; Sazonov, Igor; Karsonova, Antonina; Meyerhans, Andreas; Bocharov, Gennady A. (MDPI, 2021)
    SARS-CoV-2 infection represents a global threat to human health. Various approaches were employed to reveal the pathogenetic mechanisms of COVID-19. Mathematical and computational modelling is a powerful tool to describe ...
  • Prochnow, Hans; Prado Martínez, Javier, 1987-; Meyerhans, Andreas; Brönstrup, Mark (American Society for Microbiology, 2020)
    To counteract the serious health threat posed by known and novel viral pathogens, drugs that target a variety of viruses through a common mechanism have attracted recent attention due to their potential in treating ...
  • Riera Domínguez, María Graciela (Universitat Pompeu Fabra, 2019-02-11)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina, 1991-; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Carreras Sureda, Amado, 1986-; Rubio Moscardó, Fanny; Olvera, Alex; Argilaguet Marqués, Jordi, 1977-; Kiefer, Kerstin, 1986-; Mothe, Beatriz; Meyerhans, Andreas; Brander, Christian; Vicente García, Rubén, 1978- (Public Library of Science (PLoS), 2016)
    Single nucleotide polymorphisms (SNPs) located in the chromosome region 17q12-q21 are risk factors for asthma. Particularly, there are cis-regulatory haplotypes within this region that regulate differentially the expression ...
  • Sazonov, Igor; Grebennikov, Dmitry; Meyerhans, Andreas; Bocharov, Gennady A. (MDPI, 2021)
    Replication of Human Immunodeficiency Virus type 1 (HIV) in infected CD4+ T cells represents a key driver of HIV infection. The HIV life cycle is characterised by the heterogeneity of infected cells with respect to ...
  • Sergeeva, Julia; Grebennikov, Dmitry; Casella, Valentina, 1991-; Cebollada Rica, Paula; Meyerhans, Andreas; Bocharov, Gennady A. (MDPI, 2023)
    The lymphocytic choriomeningitis virus (LCMV) is a non-cytopathic virus broadly used in fundamental immunology as a mouse model for acute and chronic virus infections. LCMV remains a cause of meningitis in humans, in ...

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