Browsing by Author "Maldonado, Rafael, 1961-"

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  • Vázquez-Oliver, Anna; Brambilla Pisoni, Cecilia, 1993-; Domingo-Gainza, Mikel; Maldonado, Rafael, 1961-; Ivorra Cano, Antoni, 1974-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Background: Vagus nerve stimulation (VNS) using non-invasive approaches have attracted great attention due to their anti-epileptic, anti-depressive and pro-cognitive effects. It has been proposed that auricular transcutaneous ...
  • Varani, Andrés P.; Aso Pérez, Ester; Maldonado, Rafael, 1961-; Balerio, Graciela N. (Elsevier, 2014)
    The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine ...
  • Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)
    Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
  • Carcolé Estrada, Mireia, 1988-; Zamamillo Castanedo, Daniel; Merlos, Manuel; Fernández-Pastor, Begoña; Cabañero Ferri, David; Maldonado, Rafael, 1961- (Frontiers, 2019)
    Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common ...
  • Gutiérrez Martos, Miriam, 1989-; Girard, Benoît; Mendonça Netto, Sueli; Perroy, Julie; Valjent, Emmanuel; Maldonado, Rafael, 1961-; Martín Sánchez, Miquel, 1971- (Wiley-Blackwell, 2018)
    High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the ...
  • Maldonado, Rafael, 1961-; Rodríguez de Fonseca, Fernando (Society for Neuroscience, 2002)
    The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid ...
  • Ruiz de Azua, Iñigo; Martín García, Elena, 1975-; Domingo Rodriguez, Laura, 1992-; Aparisi Rey, Alejandro; Pascual Cuadrado, Diego; Islami, Larglinda; Turunen, Petri; Remmers, Floortje; Lutz, Beat; Maldonado, Rafael, 1961- (Nature Research, 2021)
    Palatable food can promote overfeeding beyond homeostatic requirements, thereby constituting a major risk to obesity. Here, the lack of cannabinoid type 1 receptor (CB1) in dorsal telencephalic glutamatergic neurons ...
  • Aso Pérez, Ester; Andrés Benito, Pol; Carmona, Margarita; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2016)
    The endogenous cannabinoid system represents a promising therapeutic target to modify neurodegenerative pathways linked to Alzheimer's disease (AD). The aim of the present study was to evaluate the specific contribution ...
  • Navarro Romero, Alba, 1990-; Galera López, Lorena, 1993-; Ortiz Romero, Paula, 1994-; Llorente-Ovejero, Alberto; Los Reyes-Ramírez, Lucía de; Bengoetxea de Tena, Iker; Garcia-Elias Heras, Anna; Mas-Stachurska, Aleksandra; Reixachs i Solé, Marina; Pastor, Antonio; Torre Fornell, Rafael de la; Maldonado, Rafael, 1961-; Benito Villabriga, Begoña; Eyras Jiménez, Eduardo; Rodríguez-Puertas, Rafael; Campuzano Uceda, María Victoria; Ozaita Mintegui, Andrés, 1969- (eLife, 2022)
    Williams-Beuren syndrome (WBS) is a rare genetic multisystemic disorder characterized by mild-to-moderate intellectual disability and hypersocial phenotype, while the most life-threatening features are cardiovascular ...
  • Navarro-Romero, Alba; Vázquez-Oliver, Anna; Gomis González, Maria, 1988-; Garzón-Montesinos, Carlos; Falcón-Moya, Rafael; Pastor, Antonio; Martín García, Elena, 1975-; Pizarro Lozano, Mª Nieves; Busquets Garcia, Arnau, 1985-; Revest, Jean-Michel; Piazza, Pier Vincenzo; Bosch, Fatima; Dierssen, Mara; Torre Fornell, Rafael de la; Rodríguez-Moreno, Antonio; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2019)
    Intellectual disability is the most limiting hallmark of Down syndrome, for which there is no gold-standard clinical treatment yet. The endocannabinoid system is a widespread neuromodulatory system involved in multiple ...
  • Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Frontiers, 2013)
    Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical ...
  • Aso Pérez, Ester; Sánchez Pla, Alexandre; Vegas Lozano, Esteban; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2015)
    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating ...
  • Mayneris Perxachs, Jordi; Castells-Nobau, Anna; Arnoriaga Rodríguez, María; Garre-Olmo, Josep; Puig, Josep; Ramos, Rafel; Martínez Hernández, Francisco; Burokas, Aurelijus, 1982-; Coll, Clàudia; Moreno-Navarrete, José Maria; Zapata-Tona, Cristina; Pedraza, Salvador; Pérez Brocal, Vicente; Ramió-Torrentà, Lluís; Ricart, Wifredo; Moya, Andrés; Martínez García, Manuel; Maldonado, Rafael, 1961-; Fernández Real, Jose M. (Elsevier, 2022)
    Growing evidence implicates the gut microbiome in cognition. Viruses, the most abundant life entities on the planet, are a commonly overlooked component of the gut virome, dominated by the Caudovirales and Microviridae ...
  • Aso Pérez, Ester; Palomer, Ernest; Juvés, Salvador; Maldonado, Rafael, 1961-; Muñoz López, Francisco José, 1964-; Ferrer, Isidre (IOS Press, 2012)
    The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, ...
  • Touriño Raposo, Clara; Ledent, Catherine; Maldonado, Rafael, 1961-; Valverde Granados, Olga (Elsevier, 2008)
    Background: 3, 4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug widely abused by young people. The endocannabinoid system is involved in the addictive processes induced by different drugs of abuse. ...
  • Saravia Santos, Rocio, 1988-; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Mato, Susana; Aso Pérez, Ester; Castro, Elena; Martín, Miguel; Valverde Granados, Olga; Maldonado, Rafael, 1961-; Pazos, Ángel (Wiley-Blackwell, 2007)
    Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioural and biochemical responses in CB1 receptor knockout mice. CB1 knockout animals exhibited ...
  • Aso Pérez, Ester; Juvés, Salvador; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2013)
    The specific CB2 cannabinoid receptor agonist JWH-133 induced cognitive improvement in double AβPP/PS1 transgenic mice, a genetic model of Alzheimer's disease. This effect was more pronounced when administered at the ...
  • Kossatz, Elk; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Elsevier, 2016)
    The role of CB2 cannabinoid receptors (CB2R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB2R in the behavioural and biochemical ...

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