Visualitza per autoria "Laayouni, Hafid, 1968-"

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  • Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes
    Colombo, Martino; Laayouni, Hafid, 1968-; Invergo, Brandon M., 1982-; Bertranpetit, Jaume, 1952-; Montanucci, Ludovica, 1978- (Wiley-VCH Verlag, 2014)
    Relationships between evolutionary rates and gene properties on a genomic, functional, pathway, or system level are being explored to unravel the principles of the evolutionary process. In particular, functional network ...
  • Natural selection in the great apes
    Cagan, Alexander; Theunert, Christoph; Laayouni, Hafid, 1968-; Santpere Baró, Gabriel, 1981-; Pybus Oliveras, Marc, 1985-; Casals López, Ferran; Prüfer, Kay; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Bertranpetit, Jaume, 1952-; Andrés Morán, Aida, 1976- (Oxford University Press, 2016)
    Natural selection is crucial for the adaptation of populations to their environments. Here, we present the first global study of natural selection in the Hominidae (humans and great apes) based on genome-wide information ...
  • PopHuman: the human population genomics browser
    Casillas, Sònia; Mulet, Roger; Villegas Mirón, Pablo; Hervas, Sergi; Sanz, Esteve; Velasco, Daniel; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968-; Barbadilla, Antonio (Oxford University Press, 2018)
    The 1000 Genomes Project (1000GP) represents the most comprehensive world-wide nucleotide variation data set so far in humans, providing the sequencing and analysis of 2504 genomes from 26 populations and reporting >84 ...
  • Positive selection in admixed populations from Ethiopia
    Walsh Capdevila, Sandra, 1991-; Pagani, Luca; Xue, Yali; Laayouni, Hafid, 1968-; Tyler-Smith, Chris; Bertranpetit, Jaume, 1952- (BioMed Central, 2020)
    Background: In the process of adaptation of humans to their environment, positive or adaptive selection has played a main role. Positive selection has, however, been under-studied in African populations, despite their ...
  • Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome
    Luisi, Pierre, 1985-; Alvarez-Ponce, David; Pybus Oliveras, Marc, 1985-; Fares, Mario A.; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2015)
    Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ...
  • Recent positive selection has acted on genes encoding proteins with more interactions within the whole human interactome
    Luisi, Pierre, 1985-; Álvarez Ponce, David; Pybus Oliveras, Marc, 1985-; Fares, Mario A.; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2015)
    Genes vary in their likelihood to undergo adaptive evolution. The genomic factors that determine adaptability, however, remain poorly understood. Genes function in the context of molecular networks, with some occupying ...
  • Selection in the introgressed regions of the chimpanzee genome
    Nye, Jessica; Laayouni, Hafid, 1968-; Kuhlwilm, Martin; Mondal, Mayukh, 1989-; Marquès i Bonet, Tomàs, 1975-; Bertranpetit, Jaume, 1952- (Oxford University Press, 2018)
    During the demographic history of the Pan clade, there has been gene-flow between species, likely >200,000 years ago. Bonobo haplotypes in three subspecies of chimpanzee have been identified to be segregating in modern-day ...
  • Signatures of genetic variation in human microRNAs point to processes of positive selection and population-specific disease risks
    Villegas Mirón, Pablo; Gallego, Alicia; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Springer, 2022)
    The occurrence of natural variation in human microRNAs has been the focus of numerous studies during the last 20 years. Most of them have been focused on the role of specific mutations in disease, while a minor proportion ...
  • Similarity in recombination rate estimates highly correlates with genetic differentiation in humans
    Laayouni, Hafid, 1968-; Montanucci, Ludovica, 1978-; Sikora, Martin, 1976-; Melé Messeguer, Marta, 1982-; Dall'Olio, Giovanni Marco, 1983-; Lorente-Galdós, Belén, 1981-; McGee, Kate M; Graffelman, Jan; Awadalla, Philip; Bosch Fusté, Elena; Comas, David, 1969-; Navarro i Cuartiellas, Arcadi, 1969-; Calafell i Majó, Francesc; Casals López, Ferran; Bertranpetit, Jaume, 1952- (Public Library of Science (PLoS), 2011)
    Recombination varies greatly among species, as illustrated by the poor conservation of the recombination landscape between humans and chimpanzees. Thus, shorter evolutionary time frames are needed to understand the evolution ...
  • The annotation and the usage of scientific databases could be improved with public issue tracker software
    Dall'Olio, Giovanni Marco, 1983-; Bertranpetit, Jaume, 1952-; Laayouni, Hafid, 1968- (Oxford University Press, 2010)
    Since the publication of their longtime predecessor The Atlas of Protein Sequences and Structures in 1965 by Margaret Dayhoff, scientific databases have become a key factor in the organization of modern science. All the ...
  • The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape
    Dobón Berenguer, Begoña, 1987-; Hassan, Hisham Y.; Laayouni, Hafid, 1968-; Luisi, Pierre, 1985-; Ricaño Ponce, Isis; Zhernakova, Alexandra; Wijmenga, Cisca; Tahir, Hanan; Comas, David, 1969-; Netea, Mihai G; Bertranpetit, Jaume, 1952- (Nature Publishing Group, 2015)
    East Africa is a strategic region to study human genetic diversity due to the presence of ethnically, linguistically, and geographically diverse populations. Here, we provide new insight into the genetic history of populations ...
  • The genetics of East African populations: a Nilo-Saharan component in the African genetic landscape [supplementary information]
    Dobon, Begoña; Hassan, Hisham Y.; Laayouni, Hafid, 1968-; Luisi, Pierre, 1985-; Ricaño Ponce, Isis; Zhernakova, Alexandra; Wijmenga, Cisca; Tahir, Hanan; Comas, David, 1969-; Netea, Mihai G; Bertranpetit, Jaume, 1952- (Universitat Pompeu Fabra, 2018-04-27)
  • The shaping of immunological responses through natural selection after the Roma Diaspora
    Dobón Berenguer, Begoña, 1987-; Ter Horst, Rob; Laayouni, Hafid, 1968-; Mondal, Mayukh, 1989-; Bianco, Erica; Comas, David, 1969-; Ioana, Mihai; Bosch Fusté, Elena; Bertranpetit, Jaume, 1952-; Netea, Mihai G (Nature Research, 2020)
    Autoinflammatory diseases (AIDs) were first described as clinical disorders characterized by recurrent episodes of seemingly unprovoked sterile inflammation. In the past few years, the identification of novel AIDs expanded ...
  • VCF2Networks: applying genotype networks to single-nucleotide variants data
    Dall'Olio, Giovanni Marco, 1983-; Vahdati, Ali R.; Bertranpetit, Jaume, 1952-; Wagner, Andreas; Laayouni, Hafid, 1968- (Oxford University Press, 2015)
    SUMMARY: A wealth of large-scale genome sequencing projects opens the doors to new approaches to study the relationship between genotype and phenotype. One such opportunity is the possibility to apply genotype networks ...
  • Y-chromosomal sequences of diverse Indian populations and the ancestry of the Andamanese
    Mondal, Mayukh, 1989-; Bergström, Anders; Xue, Yali; Calafell i Majó, Francesc; Laayouni, Hafid, 1968-; Casals López, Ferran; Majumder, Partha P.; Tyler-Smith, Chris; Bertranpetit, Jaume, 1952- (Springer, 2017)
    We present 42 new Y-chromosomal sequences from diverse Indian tribal and non-tribal populations, including the Jarawa and Onge from the Andaman Islands, which are analysed within a calibrated Y-chromosomal phylogeny ...

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