Browsing by Author "López-Botet, Miguel"

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  • Low cytomegalovirus seroprevalence in early multiple sclerosis: a case for the 'hygiene hypothesis'?
    Alari-Pahissa, Elisenda; Moreira Villanueva, Antía; Zabalza, Ana; Alvarez-Lafuente, Roberto; Munteis Olivas, Elvira; Vera, Andrea; Arroyo, Rafael; Álvarez Cermeño, Jose Carlos; Villar, Luisa Maria; López-Botet, Miguel; Martínez-Rodriguez, José E. (Wiley, 2018)
    BACKGROUND AND PURPOSE: Cytomegalovirus (CMV) infection has recently been associated with a lower multiple sclerosis (MS) susceptibility, although it remains controversial whether it has a protective role or is merely an ...
  • Natural Killer Cell-Based Immunotherapy in Acute Myeloid Leukemia: Lessons for the Future.
    Muntasell i Castellví, Aura, 1972-; López-Botet, Miguel (American Association for Cancer Research, 2016)
    The report by Curti et al. highlightsthe potential of NK cell-based adoptive cellular immunotherapy in oncology,currently boosted by advances in the knowledge on NK cell biology and in their ex-vivo GMP manipulation.Several ...
  • NK cells eliminate Epstein-Barr virus bound to B cells through a specific antibody-mediated uptake
    Alari-Pahissa, Elisenda; Ataya Fernández, Michelle, 1993-; Moraitis, Ilias; Campos Ruiz, Miriam; Altadill, Mireia; Muntasell i Castellví, Aura, 1972-; Moles, Anna; López-Botet, Miguel (Public Library of Science (PLoS), 2021)
    Epstein Barr virus (EBV) causes a highly prevalent and lifelong infection contributing to the development of some malignancies. In addition to the key role played by T cells in controlling this pathogen, NK cells mediate ...
  • Peripheral blood lymphocyte subsets change after steroid withdrawal in renal allograft recipients: a prospective study
    Llinàs-Mallol, Laura; Redondo Pachón, María Dolores; Pérez-Sáez, María José; Raïch-Regué, Dàlia; Mir, Marisa; Yélamos López, José; López-Botet, Miguel; Pascual Santos, Julio; Crespo Barrio, Marta (Nature Research, 2019)
    Several studies have assessed clinical outcomes after steroid withdrawal (SW) in kidney transplant (KT) recipients, but little is known about its potential impact on lymphocyte subpopulations. We designed a prospective ...
  • Pretransplant adaptive NKG2C+ NK cells protect against cytomegalovirus infection in kidney transplant recipients
    Ataya Fernández, Michelle, 1993-; Redondo Pachón, María Dolores; Llinàs-Mallol, Laura; Yélamos López, José; Heredia, Gemma; Pérez-Sáez, María José; Vila, Joan; Costa García, Marcel, 1989-; Raïch-Regué, Dàlia; Vilches, Carlos; Pascual, Julio (Pascual Santos); Crespo Barrio, Marta; López-Botet, Miguel (Wiley-Blackwell, 2019)
    Cytomegalovirus (CMV) infection constitutes a complication for kidney transplant recipients (KTR) and CMV-specific T cells reduce the risk of viral replication in seropositive patients. CMV promotes the adaptive differentiation ...
  • Priming of NK cell anti-viral effector mechanisms by direct recognition of human cytomegalovirus
    Muntasell i Castellví, Aura, 1972-; Costa-García, Marcel; Vera, Andrea; Marina-García, Noemí; Kirschning, Carsten J.; López-Botet, Miguel (Frontiers, 2013)
    Natural killer (NK) cells play an important role in the defense against viral infections. Activation of resting NK cells is tightly controlled by the balance of surface inhibitory and activating receptors and aided by ...
  • Serum cytokine levels as predictive biomarkers of benefit from ipilimumab in small cell lung cancer
    Hardy-Werbin, Max; Rocha, Pedro P.; Arpí Llucià, Oriol; Taus García, Álvaro; Nonell Mazelón, Lara; Duran Jordà, Xavier, 1974-; Villanueva, Xavier; Joseph-Pietras, Deborah; Nolan, Luke; Danson, Sarah; Griffiths, Richard; López-Botet, Miguel; Rovira Guerín, Ana; Albanell Mestres, Joan; Ottensmeier, Christian; Arriola Aperribay, Edurne (Taylor & Francis, 2019)
    Background. Immunotherapy has shown efficacy in small cell lung cancer (SCLC), but only a subset of patients benefits. Surrogate biomarkers are urgently needed. Our aim was to evaluate serum Th1, Th2, and proinflammatory ...