Browsing by Author "López Bigas, Núria"

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  • Porta-Pardo, Eduard; Kamburov, Atanas; Tamborero Noguera, David; Pons, Tirso; Grases, Daniela; Valencia, Alfonso; López Bigas, Núria; Getz, Gad; Godzik, Adam (Nature Publishing Group, 2017)
    Understanding genetic events that lead to cancer initiation and progression remains one of the biggest challenges in cancer biology. Traditionally, most algorithms for cancer-driver identification look for genes that have ...
  • Bailey, Matthew H.; López Bigas, Núria; Ding, Li (Elsevier, 2018)
    Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on large datasets are few. We report ...
  • Tamborero Noguera, David; González-Pérez, Abel; Pérez Llamas, Christian, 1976-; Déu Pons, Jordi; Kandoth, Cyriac; Reimand, Jüri; Lawrence, Michael S.; Getz, Gad; Bader, Gary D.; Ding, Li; López Bigas, Núria (Nature Publishing Group, 2013)
    With the ability to fully sequence tumor genomes/exomes, the quest for cancer driver genes can now be undertaken in an unbiased manner. However, obtaining a complete catalog of cancer genes is difficult due to the heterogeneous ...
  • Pérez Llamas, Christian (Universitat Pompeu Fabra, 2015-12-22)
    Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are exploiting these technologies ...
  • González-Pérez, Abel; López Bigas, Núria (Nature Research, 2013)
    The International Cancer Genome Consortium (ICGC) aims to catalog genomic abnormalities in tumors from 50 different cancer types. Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only ...
  • Kranas, Hanna (Universitat Pompeu Fabra, 2023-11-08)
    Living cells are exposed to naturally occurring DNA-damaging agents that promote the loss of genome integrity, threatening the proper functioning of the cell. To counteract the toxic accumulation of DNA damage, organisms ...
  • Bonet Giner, Jose (Universitat Pompeu Fabra, 2022-06-20)
    Sequencing technologies have recently evolved and generated large amounts of data. These datasets have had significant impacts in the cancer field and the detection of damage and repair mechanisms. Methodologies to analyze ...
  • Gundem, Gunes (Universitat Pompeu Fabra, 2012-01-26)
    In my thesis, I focused on integrative analysis of high-throughput oncogenomic data. This was done in two parts: In the first part, I describe IntOGen, an integrative data mining tool for the study of cancer. This system ...
  • Nicolay, Brandon N.; Bayarmagnai, Battuya; Islam, Abul, 1978-; López Bigas, Núria; Frolov, Maxim V. (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    The Hippo signaling pathway regulates organ size homeostasis, while its inactivation leads to severe hyperplasia in flies and mammals. The transcriptional coactivator Yorkie (Yki) mediates transcriptional output of the ...
  • Gallardo Hernández, Fernando; Padrón, Andreina; Garcia Carbonell, Ricard; Rius, Cristina; González-Pérez, Abel; Arumí, Montserrat; Iglesias Coma, Mar; Nonell Mazelón, Lara; Bellosillo Paricio, Beatriz; Segura Tigell, Sonia; Pujol Vallverdú, Ramon Maria; López Bigas, Núria; Bertran, Joan; Bigas Salvans, Anna; Espinosa Blay, Lluís (Impact Journal, 2015)
    Invasive malignant melanoma (MM) is an aggressive tumor with no curative therapy available in advanced stages. Nuclear corepressor (NCoR) is an essential regulator of gene transcription, and its function has been found ...
  • Bonet, Jose; Chen, Mandi; Dabad, Marc; Heath, Simon; Gonzalez-Perez, Abel; López Bigas, Núria; Lagergren, Jens (Oxford University Press, 2021)
    Motivation: DNA Methylation plays a key role in a variety of biological processes. Recently, Nanopore long-read sequencing has enabled direct detection of these modifications. As a consequence, a range of computational ...
  • Islam, Abul (Universitat Pompeu Fabra, 2012-10-10)
    Recent advances in high throughput technology have opened the door to systematic studies of epigenetic mechanisms. One of the key components in the regulation of the cell cycle and differentiation is the retinoblastoma ...
  • Nadeu, Ferran; Massoni-Badosa, Ramon; Ruiz Gil, Sara; Marchese, Domenica, 1986-; López Bigas, Núria; Gut, Ivo Glynne; Heyn, Holger; Campo, Elias (Nature Research, 2022)
    Richter transformation (RT) is a paradigmatic evolution of chronic lymphocytic leukemia (CLL) into a very aggressive large B cell lymphoma conferring a dismal prognosis. The mechanisms driving RT remain largely unknown. ...
  • Frigola Rissech, Joan (Universitat Pompeu Fabra, 2020-09-15)
    The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational biases that encompass ...
  • Furney, Simon J.; Albà Soler, Mar; López Bigas, Núria (BioMed Central, 2006)
    Background: Global analyses of human disease genes by computational methods have yielded important advances in the understanding of human diseases. Generally these studies have treated the group of disease genes uniformly, ...
  • López Bigas, Núria; De, Subhajyoti; Teichmann, Sarah A. (Universitat Pompeu Fabra, 2007-10)
    Mutations, genes and pathways involved in tumorigenesis across 4,623 cancer genomes/exomes from 13 cancer sites. IntOGen-mutations identifies cancer drivers across tumor types. Nature Methods 10, 2013, doi:10.1038/nmeth.2642
  • Shikhagaie, Medya; López Bigas, Núria (Universitat Pompeu Fabra, 2007-10)
    Web tool for the selection of SNPs from the STAR project with potential functional effect.
  • López Bigas, Núria; González-Pérez, Abel (Oxford University Press, 2012)
    Identifying cancer driver genes and pathways among all somatic mutations detected in a cohort of tumors is a key challenge in cancer genomics. Traditionally, this is done by prioritizing genes according to the recurrence ...
  • Beshiri, Michael L.; Islam, Abul, 1978-; DeWaal, Dannielle C.; Richter, William F.; Love, Jennifer; López Bigas, Núria; Benevolenskaya, Elizaveta V. (MYJoVE Corporation, 2010)
    Recruitment of transcriptional and epigenetic factors to their targets is a key step in their regulation. Prominently featured in recruitment are the protein domains that bind to specific histone modifications. One such ...
  • Pérez Llamas, Christian, 1976-; López Bigas, Núria; Schroeder, Michael Philipp, 1986-; Déu Pons, Jordi (Universitat Pompeu Fabra, 2016-07-05)
    Gitools is a framework for analysis and visualization of multidimensional genomic data using interactive heat-maps

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