Browsing by Author "Grau-Rivera, Oriol"

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  • Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels
    Brugulat Serrat, Anna, 1986-; Cañas-Martínez, Alba; Canals-Gispert, Lidia; Marne, Paula; Gramunt Fombuena, Nina; Suárez-Calvet, Marc; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; ALFA Study (IOS Press, 2021)
    Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals ...
  • Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
    Cacciaglia, Raffaele; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; Falcón, Carles; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Grau-Rivera, Oriol; Gispert López, Juan Domingo; ALFA Study (Wiley, 2018)
    The neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies reported that larger brain ...
  • Exploring cognitive and biological correlates of sleep quality and their potential links with Alzheimer's disease (ALFASleep project). Protocol for an observational study
    Fauria, Karine; Minguillón, Carolina; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Suárez-Calvet, Marc; Domingo Gispert, Juan; Grau-Rivera, Oriol (BMJ Publishing Group, 2022)
    Introduction: the growing worldwide prevalence of Alzheimer's disease (AD) and the lack of effective treatments pose a dire medical challenge. Sleep disruption is also prevalent in the ageing population and is increasingly ...
  • Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Genius, Patricia; Rodríguez-Fernández, Blanca; Minguillón, Carolina; Sadeghi, Iman; González Escalante, Armand; Crous-Bou, Marta; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Esteller, Manel; Fauria, Karine; Molinuevo, José Luis; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Wiley, 2024)
    Introduction: In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive ...
  • Lifetime stressful events associated with Alzheimer's Pathologies, neuroinflammation and brain structure in a risk enriched cohort
    Palpatzis, Eleni; Akinci, Muge; Aguilar Dominguez, Pablo; Garcia Prat, Marina; Blennow, Kaj; Zetterberg, Henrik; Carboni, Margherita; Kollmorgen, Gwendlyn; Wild, Norbert; Fauria, Karine; Falcón, Carles; Gispert López, Juan Domingo; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; ALFA Study (Wiley, 2024)
    Objective: Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the ...
  • Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected
    Suárez-Calvet, Marc; Milà Alomà, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Minguillón, Carolina; Shekari, Mahnaz; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Sala Vila, Aleix; González de Echávarri, José Maria; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was ...
  • Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
    Brugulat Serrat, Anna, 1986-; Salvadó, Gemma; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Springer, 2019)
    White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and ...
  • Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Plasma and CSF biomarkers in a memory clinic: head-to-head comparison of phosphorylated tau immunoassays
    Ashton, Nicholas J.; Puig Pijoan, Albert; Milà Alomà, Marta; Fernández-Lebrero, Aida; Ortiz Romero, Paula, 1994-; Minguillón, Carolina; Navalpotro-Gómez, Irene; Grau-Rivera, Oriol; Manero, Rosa María; Puente Periz, Victor Manuel; Torre Fornell, Rafael de la; Roquer, Jaume; Suárez-Calvet, Marc (Wiley, 2023)
    Introduction: Direct comparisons of the main blood phosphorylated tau immunoassays in memory clinic populations are needed to understand possible differences. Methods: In the BIODEGMAR study, 197 participants presenting ...
  • Prepandemic alzheimer disease biomarkers and anxious-depressive symptoms during the COVID-19 confinement in cognitively unimpaired adults
    Akinci, Muge; Peña-Gómez, Cleofé; Operto, Grégory; Fuentes-Julian, Sherezade; Deulofeu, Carme; Sánchez Benavides, Gonzalo; Milà Alomà, Marta; Grau-Rivera, Oriol; Gramunt Fombuena, Nina; Navarro i Cuartiellas, Arcadi, 1969-; Minguillón, Carolina; Fauria, Karine; Suridjan, Ivonne; Kollmorgen, Gwendlyn; Bayfield, Anna; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer disease (AD), which may accelerate disease progression. We investigated whether β-amyloid, cortical ...
  • Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
    Sánchez Benavides, Gonzalo; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Milà Alomà, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Crous-Bou, Marta; Niñerola-Baizán, Aida; Perissinotti, Andrés; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) ...
  • Risk of cognitive decline progression is associated to increased blood-brain-barrier permeability: A longitudinal study in a memory unit clinical cohort
    Puig-Pijoan, Albert; Jimenez-Balado, Joan; Fernández-Lebrero, Aida; García-Escobar, Greta; Navalpotro-Gómez, Irene; Contador, Jose; Manero Borràs, Rosa María; Puente Periz, Victor Manuel; Suárez, Antoni; Muñoz, Francisco J.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Torre Fornell, Rafael de la; Roquer, Jaume; Ois Santiago, Angel Javier (Wiley, 2024)
    Introduction: This study examined the relationship between blood-brain-barrier permeability (BBBp), measured by cerebrospinal fluid/serum albumin ratio (QAlb), and cognitive decline progression in a clinical cohort. Methods: ...
  • Soundtrack of life: an fMRI study
    Falcon, Carles; Navarro-Plaza, Mari Carmen; Gramunt Fombuena, Nina; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Cacciaglia, Raffaele; González de Echávarri, José Maria; Sanchez-Benavides, Gonzalo; Operto, Grégory; Knezevic, Iva; Molinuevo, José Luis; Domingo Gispert, Juan (Elsevier, 2022)
    Most people have a soundtrack of life, a set of special musical pieces closely linked to certain biographical experiences. Autobiographical memories (AM) and music listening (ML) involve complex mental processes ruled by ...
  • Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort
    Salvadó, Gemma; Brugulat Serrat, Anna, 1986-; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2019)
    Background: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH associated with dementia ...
  • Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
    Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...
  • The mediating role of neuroimaging-derived biological brain age in the association between risk factors for dementia and cognitive decline in middle-aged and older individuals without cognitive impairment: a cohort study
    Cumplido-Mayoral, Irene; Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; González Escalante, Armand; Anastasi, Federica; Milà Alomà, Marta; López Martos, David; Akinci, Muge; Falcón, Carles; Shekari, Mahnaz; Cacciaglia, Raffaele; Arenaza Urquijo, Eider M.; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Vilaplana, Verónica; Gispert López, Juan Domingo; ALFA Study (Elsevier, 2024)
    Background: Neuroimaging-based brain-age delta has been shown to be a mediator linking cardiovascular risk factors to cognitive function. We aimed to assess the mediating role of brain-age delta in the association between ...
  • White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
    Brugulat Serrat, Anna, 1986-; Salvadó, Glòria; Operto, Grégory; Cacciaglia, Raffaele; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Minguillón, Carolina; Fauria, Karine; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Wiley, 2020)
    White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH lesion volume mediates the relationship ...
  • White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes
    Operto, Grégory; Cacciaglia, Raffaele; Grau-Rivera, Oriol; Falcón, Carles; Brugulat Serrat, Anna, 1986-; Ródenas, Pablo; Ramos, Rubén; Morán, Sebastián; Esteller, Manel; Bargalló-Gispert, Núria; Molinuevo, José Luis; Domingo Gispert, Juan; ALFA Study (BioMed Central, 2018)
    Background: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer’s disease. During middle age, cognitively healthy APOE-ε4 carriers already show several brain ...

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