Browsing by Author "García de Herreros, Antonio"

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  • Moustakas, Aristidis; García de Herreros, Antonio (Wiley, 2017)
  • Peláez García, Alberto; Barderas, Rodrigo; Torres, Sofía; Teixidó, Joaquín; Bonilla, Félix; García de Herreros, Antonio; Hernández-Varas, Pablo; Casal, José Ignacio (Public Library of Science (PLoS), 2013)
    Fibroblast growth factor receptor 4 (FGFR4) is vital in early development and tissue repair. FGFR4 expression levels are very restricted in adult tissues, except in several solid tumors including colorectal cancer, which ...
  • Mestre-Farrera, Aida, 1992-; Bruch-Oms, Marina; Peña Arranz, Raúl, 1976-; Rodríguez-Morató, Jose, 1987-; Alba Castellón, Lorena, 1984-; Comerma Blesa, Laura, 1983-; Quintela-Fandino, Miguel; Duñach, Mireia; Baulida i Estadella, Josep, 1965-; Pozo Mendoza, Óscar J., 1975-; García de Herreros, Antonio (American Association for Cancer Research (AACR), 2021)
    Tumors are complex tissues composed of transformed epithelial cells as well as cancer-activated fibroblasts (CAF) that facilitate epithelial tumor cell invasion. We show here that CAFs and other mesenchymal cells rely much ...
  • Yang, Jing; García de Herreros, Antonio; Sheng, Guojun; EMT International Association (TEMTIA) (Nature Research, 2020)
    Epithelial-mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a ...
  • Millanes Romero, Alba, 1986- (Universitat Pompeu Fabra, 2014-01-21)
    Although heterochromatin is enriched with repressive traits, it is actively transcribed, giving rise to large amounts of non-coding RNAs. These transcripts are responsible for the formation and maintenance of heterochromatin, ...
  • Iturbide Martínez de Albéniz, Ane, 1989- (Universitat Pompeu Fabra, 2017-11-20)
    Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
  • García de Herreros, Antonio; Duñach, Mireia (MDPI, 2019)
    In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This ...
  • Pascual-Reguant, Laura; Blanco, Enrique; Galan Martínez, Silvia, 1992-; Le Dily, François; Cuartero, Yasmina; Serra Bardenys, Gemma, 1992-; Di Carlo, Valerio; Iturbide Martínez de Albéniz, Ane, 1989-; Cebrià i Costa, Joan Pau, 1989-; Nonell Mazelón, Lara; García de Herreros, Antonio; Di Croce, Luciano; Marti-Renom, Marc A.; Peiró Sales, Sandra (Nature Publishing Group, 2018)
    Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, ...
  • Iturbide Martínez de Albéniz, Ane, 1989-; Pascual-Reguant, Laura; Fargas Madriles, Laura, 1989-; Cebrià i Costa, Joan Pau, 1989-; Alsina i Español, Berta; García de Herreros, Antonio; Peiró Sales, Sandra (Elsevier, 2015)
    Protein function is often regulated and controlled by posttranslational modifications, such as oxidation. Although oxidation has been mainly considered to be uncontrolled and nonenzymatic, many enzymatic oxidations occur ...
  • Cebrià i Costa, Joan Pau, 1989-; Pascual-Reguant, Laura; Gonzalez-Perez, Abel; Serra Bardenys, Gemma, 1992-; Querol, J.; Cosín, M.; Verde, Gaetano; Cigliano, Riccardo Aiese; Sanseverino, Walter; Segura-Bayona, Sandra; Iturbide Martínez de Albéniz, Ane, 1989-; Andreu Martínez, David; Nuciforo, Paolo G.; Bernado-Morales, C.; Rodilla, Verónica; Arribas, Joaquín; Yélamos López, José; García de Herreros, Antonio; Stracker, Travis; Peiró Sales, Sandra (Nature Research, 2020)
    Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) ...
  • Herranz Martín, Nicolás; Dave, Natàlia; Millanes Romero, Alba, 1986-; Morey Ramonell, Lluís; Díaz, Víctor M.; Lórenz Fonfria, Víctor; Gutiérrez Gallego, Ricardo, 1968-; Jerónimo, Celia; Di Croce, Luciano; García de Herreros, Antonio; Peiró Sales, Sandra (American Society for Cell Biology, 2012)
    Methylation of lysine 4 (K4) within histone H3 has been linked to active transcription and is removed by LSD1 and the JmjC domain-containing proteins by amino-oxidation or hydroxylation, respectively. Here, we describe the ...
  • Domínguez Solà, David (Universitat Pompeu Fabra, 2003-04-03)
    Els factors de transcripció de la família Snail són fonamentals en la "transició epiteli-mesènquima", procés morfogènic essencial en el desenvolupament embrionari i en els fenòmens metastàsics tumorals.<br/>En els mamífers ...
  • Mestre-Farrera, Aida, 1992- (Universitat Pompeu Fabra, 2020-02-27)
    Tumors are complex tissues composed by multiple cell types, such as cancer associated fibroblasts (CAFs), that facilitate the invasive behavior of tumor cells. When we examined their nutrient requirements, we observed that ...
  • Vinyoles, Meritxell; Valle Pérez, Beatriz del; Curto, Josué; Viñas Castells, Rosa, 1985-; Alba Castellón, Lorena, 1984-; García de Herreros, Antonio; Duñach, Mireia (Elsevier, 2014)
    The Wnt canonical ligands elicit the activation of β-catenin transcriptional activity, a response dependent on, but not limited to, β-catenin stabilization through the inhibition of GSK3 activity. Two mechanisms have been ...
  • Aparicio i Prat, Estel (Universitat Pompeu Fabra, 2015-07-14)
    Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT is transcribed from a ...
  • Herranz Martín, Nicolás (Universitat Pompeu Fabra, 2011-09-23)
    The epithelial to mesenchymal transition (EMT) is a highly conserved cellular program that allows well-­‐differentiated epithelial cells to convert to motile mesenchymal cells. EMT is critical for appropriate embryogenes ...
  • Olivera-Salguero, Rubén, 1991- (Universitat Pompeu Fabra, 2019-07-19)
    Snail1 is the master regulator of the Epithelial-to-Mesenchymal Transition (EMT) and is also crucial for fibroblast activation upon TGFβ signaling. In cancer, Snail1 expression in primary tumors correlates with the appearance ...
  • Fuertes, Guillem; Valle Pérez, Beatriz del; Pastor Ruiz, Javier; Andrades, Evelyn; Peña Arranz, Raúl, 1976-; García de Herreros, Antonio; Duñach, Mireia (EMBO Press, 2023)
    Colon tumors of the mesenchymal subtype have the lowest overall survival. Snail1 is essential for the acquisition of this phenotype, characterized by increased tumor stemness and invasion, and high resistance to chemotherapy. ...
  • Larriba, María Jesús; Casado Vela, Juan; Pendás Franco, Natalia; Peña, Raúl; García de Herreros, Antonio; Berciano, María Teresa; Lafarga, Miguel; Casal, José Ignacio; Muñoz, Alberto (Public Library of Science (PLoS), 2010)
    Background: The transcription factor Snail1 induces epithelial-to-mesenchymal transition (EMT), a process responsible for the acquisition of invasiveness during tumorigenesis. Several transcriptomic studies have ...
  • Viñas Castells, Rosa, 1985-; Frías Hernández, Àlex, 1985-; Robles Lanuza, Estefanía; Zhang, Kun; Longmore, Gregory D; García de Herreros, Antonio; Díaz, Víctor M. (Oxford University Press, 2014)
    The zinc finger transcription factor Snail1 regulates epithelial to mesenchymal transition, repressing epithelial markers and activating mesenchymal genes. Snail1 is an extremely labile protein degraded by the cytoplasmic ...

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