Browsing by Author "Espinosa Blay, Lluís"

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  • Modulation of mitochondrial and inflammatory homeostasis through RIP140 is neuroprotective in an adrenoleukodystrophy mouse model
    Ranea-Robles, Pablo; Galino, Jorge; Espinosa Blay, Lluís; Schlüter, Agatha; Ruiz, Montserrat; Calingasan, Noel Ylagan; Villarroya, Francesc; Naudí, Alba; Pamplona, Reinald; Ferrer, Isidre; Beal, M. Flint; Portero Otín, Manuel; Fourcade, Stéphane; Pujol, Aurora, 1968- (Wiley, 2022)
    Aims: Mitochondrial dysfunction and inflammation are at the core of axonal degeneration in several multifactorial neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease, and Parkinson's disease. The ...
  • NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
    Colomer Montañà, Carlota, 1990-; Marruecos, Laura; Vert, Anna; Bigas Salvans, Anna; Espinosa Blay, Lluís (MDPI, 2017)
    Nuclear factor-κB (NF-κB) has been long considered a master regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been linked with carcinogenesis in many types of cancer. In recent ...
  • NF-κB-dependent and -independent (moonlighting) IκBα functions in differentiation and cancer
    Espinosa Blay, Lluís (MDPI, 2021)
    IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, ...
  • Notch activation and downstream targets in embryonic hematopoiesis
    Guiu Sagarra, Jordi, 1983- (Universitat Pompeu Fabra, 2012-11-26)
    La regió de l’aorta-gonada-mesonefros (AGM) és el primer nínxol de les cèl·lules mare hematopoètiques. Està descrit que la via de Notch és necessària per generar artèries i cèl·lules mare hematopoètiques. Les cèl·lules ...
  • Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation
    Porcheri, Cristina; Golan, Ohad; Calero-Nieto, Fernando J.; Thambyrajah, Roshana; Ruiz-Herguido, Cristina; Wang, Xiaonan; Catto, Francesca; Guillén, Yolanda; Sinha, Roshani, 1989-; González, Jessica; Kinston, Sarah J.; Mariani, Samanta A.; Maglitto, Antonio; Vink, Chris S.; Dzierzak, Elaine; Charbord, Pierre; Göttgens, Bertie; Espinosa Blay, Lluís; Sprinzak, David; Bigas Salvans, Anna (Wiley-Blackwell, 2020)
    Hematopoietic stem cells (HSCs) develop from the hemogenic endothelium in cluster structures that protrude into the embryonic aortic lumen. Although much is known about the molecular characteristics of the developing ...
  • Notch signal strength controls cell fate in the haemogenic endothelium.
    Gama-Norton, Leonor; Ferrando Martorell, Eva, 1986-; Ruiz Herguido, Cristina; Liu, Zenhy; Guiu Sagarra, Jordi, 1983-; Islam, Abul, 1978-; Lee, Sung-Uk; Yan, Minhong; Guidos, Cynthia J.; López Bigas, Núria; Maeda, Takahiro; Espinosa Blay, Lluís; Kopan, Raphael; Bigas Salvans, Anna (Nature Publishing Group, 2015)
    Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta-gonad-mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the ...
  • Notch signalling in intestinal homeostasis and cancer: orchestrator of stemness
    López Arribillaga, Erika, 1986- (Universitat Pompeu Fabra, 2016-06-17)
    Wnt/β-catenin and Notch signalling cooperate in regulating the transcription of various genes specifically in the small intestinal stem and progenitor cell compartments. We characterized Bmi1 functionally in this context ...
  • Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma
    Gallardo Hernández, Fernando; Bertran, Joan; López Arribillaga, Erika, 1986-; González, Jessica; Menéndez, Silvia; Sánchez Güerri, Ignacio; Colomo Saperas, Luis Alberto; Iglesias Coma, Mar; Garrido, Marta; Santamaría-Babí, Luis Francisco; Torres, Ferran; Pujol Vallverdú, Ramon Maria; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Publishing Group, 2018)
  • p27
    Pippa, Raffaella; Espinosa Blay, Lluís; Gundem, Gunes; Garcia Escudero, Ramon; Dominguez, Ana; Orlando, S.; Gallastegui, E.; Saiz, Cristina; Besson, Arnaud; Pujol, Maria Jesus; López Bigas, Núria; Paramio, Jesus M.; Bigas Salvans, Anna; Bachs Valldeneu, Oriol (Universitat Pompeu Fabra, 2011-12)
    The cyclin-cdk (cyclin-dependent kinase) inhibitor p27(Kip1) (p27) has a crucial negative role on cell cycle progression. In addition to its classical role as a cyclin-cdk inhibitor, it also performs cyclin-cdk-independent ...
  • p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
    Solé, Laura; Lobo-Jarne, Teresa; Álvarez-Villanueva, Daniel; Alonso-Marañón, Josune; Guillén, Yolanda; Guix Arnau, Marta, 1974-; Sangrador, Irene; Rozalén, Catalina; Vert, Anna; Lop Gros, Joan; Salido Galeote, Marta; Bellosillo Paricio, Beatriz; García-Romero, Raquel; Garrido, Marta; González, Jessica; López Arribillaga, Erika, 1986-; Iglesias Coma, Mar; Celià-Terrassa, Toni; Bigas Salvans, Anna; Espinosa Blay, Lluís (Nature Research, 2022)
    Current therapy against colorectal cancer (CRC) is based on DNA-damaging agents that remain ineffective in a proportion of patients. Whether and how non-curative DNA damage-based treatment affects tumor cell behavior and ...
  • Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.
    Giorgetti, Alessandra; Castaño, Julio; Bueno, Clara; Diaz de la Guardia, Rafael; Delgado, Mario; Bigas Salvans, Anna; Espinosa Blay, Lluís; Menéndez, Pablo (Elsevier, 2017)
    Recent studies in zebrafish and mice have revealed that proinflammatory signaling is a positive regulator of definitive hematopoietic development. Whether proinflammatory signaling also regulates human hematopoietic ...
  • Recent advances in T-cell lymphoid neoplasms
    Bigas Salvans, Anna; Rodríguez-Sevilla, Juan José; Espinosa Blay, Lluís; Gallardo Hernández, Fernando (Elsevier, 2022)
    T Cells comprise many subtypes of specified lymphocytes, and their differentiation and function take place in different tissues. This cellular diversity is also observed in the multiple ways T-cell transformation gives ...
  • Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
    Cantero Recasens, Gerard, 1984-; Alonso-Marañón, Josune; Lobo-Jarne, Teresa; Garrido, Marta; Iglesias Coma, Mar; Espinosa Blay, Lluís; Malhotra, Vivek (eLife, 2022)
    Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier ...
  • Sézary syndrome patient-derived models allow drug selection for personalized therapy
    Gallardo Hernández, Fernando; Andrades, Evelyn; Iglesias, Arnau; González, Jessica; Solé, Laura; Guillén, Yolanda; Blanco Ares, Gonzalo, 1989-; Colomo Saperas, Luis Alberto; Gimeno Vázquez, Eva; Conde Estévez, David; Rodríguez, Eva; Bielsa-Marsol, Isabel; Iglesias Coma, Mar; Bellosillo Paricio, Beatriz; Pujol Vallverdú, Ramon Maria; Regueiro, José R.; Bigas Salvans, Anna; Espinosa Blay, Lluís (American Society of Hematology, 2022)
    Current therapeutic approaches for Sézary syndrome (SS) do not achieve a significant improvement in long-term survival of patients, and they are mainly focused on reducing blood tumor burden to improve quality of life. ...
  • Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression
    Marruecos, Laura; Manils, Joan; Moreta, Cristina; Gómez, Diana; Filgaira, Ingrid; Serafín, Anna; Cañas, Xavier; Espinosa Blay, Lluís; Soler, Concepció (Nature Research, 2021)
    Dose of Trp53, the main keeper of genome stability, influences tumorigenesis; however, the causes underlying and driving tumorigenesis over time by the loss of a single p53 allele are still poorly characterized. Here, we ...
  • SIRT6-dependent cysteine monoubiquitination in the PRE-SET domain of Suv39h1 regulates the NF-κB pathway
    Santos-Barriopedro, Irene; Bosch-Presegué, Laia; Marazuela-Duque, Anna; Torre, Carolina de la; Colomer Montañà, Carlota, 1990-; Vázquez, Berta N.; Fuhrmann, Thomas; Martínez-Pastor, Bárbara; Lu, Wenfu; Braun, Thomas; Bober, Eva; Jenuwein, Thomas; Serrano, Lourdes; Esteller, Manel; Chen, Zhenbang; Barceló-Batllori, Silvia; Mostoslavsky, Raúl; Espinosa Blay, Lluís; Vaquero, Alejandro (Nature Publishing Group, 2018)
    Sirtuins are NAD+-dependent deacetylases that facilitate cellular stress response. They include SirT6, which protects genome stability and regulates metabolic homeostasis through gene silencing, and whose loss induces an ...
  • The multiple usages of Notch signaling in development, cell differentiation and cancer
    Bigas Salvans, Anna; Espinosa Blay, Lluís (Elsevier, 2018)
    Notch is a well-conserved signaling pathway all through evolution that is crucial to specify different cell fates. Although there is a strong context dependent component in each decision, the basic mechanisms that originate ...
  • Understanding the molecular mechanisms involved in Notch1 induced T-cell acute lymphoblastic leukemia
    D'Altri, Teresa, 1984- (Universitat Pompeu Fabra, 2013-07-26)
  • Unravelling new oncogenic functions of IKKα : towards a better understanding of colorectal carcinogenesis
    Colomer Montañà, Carlota, 1990- (Universitat Pompeu Fabra, 2019-01-14)
    Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
  • β-Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T-cell acute lymphoblastic leukemia
    García Hernández, Violeta; Arambilet, David; Guillén, Yolanda; Lobo-Jarne, Teresa; Maqueda, Maria; Gekas, Christos; González, Jessica; Iglesias, Arnau; Vega García, Nerea; Sentís Carreras, Inés 1990-; Trincado Alonso, Juan Luis, 1987-; Márquez-López, Ian; Heyn, Holger; Camós, Mireia; Espinosa Blay, Lluís; Bigas Salvans, Anna (Wiley, 2023)
    Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β-catenin/CTNNB1 in the ...