Browsing by Author "Espinet Solà, Blanca"

Sort by: Order: Results:

  • NOTCH1 mutation in chronic lymphocytic leukaemia is associated with an enhanced cell cycle G1/S transition and specific cyclin overexpression. Preclinical ground for targeted inhibition
    Carrillo-Tornel, Salvador; Chen-Liang, Tzu Hua; Zurdo, María; Puiggros Metje, Anna Maria; Gómez-Llonín, Andrea; García-Malo, María Dolores; Cuenca-Zamora, Ernesto José; Ortuño, Francisco José; Hurtado López, Ana María; Espinet Solà, Blanca; Jerez, Andrés (Wiley, 2022)
    Studies prior to next-generation sequencing (NGS) showed that the frequent indolent course of chronic lymphocytic leukaemia (CLL) is related to most cells remaining quiescent in the G0 -G1 cell cycle phase, due to the ...
  • Oligomonocytic and overt chronic myelomonocytic leukemia show similar clinical, genomic, and immunophenotypic features
    Calvo Gonzalo, Xavier; García-Gisbert, Nieves; Parraga, Ivonne; Gibert, Joan; Florensa Brichs, Lourdes; Andrade-Campos, Marcio; Merchan, Brayan; García-Avila, Sara; Montesdeoca, Sara; Fernández Rodríguez, M. Concepción; Salido Galeote, Marta; Puiggros Metje, Anna Maria; Espinet Solà, Blanca; Colomo Saperas, Luis Alberto; Roman-Bravo, David; Bellosillo Paricio, Beatriz; Ferrer Del Alamo, Ana; Arenillas Rocha, Leonor (American Society of Hematology, 2020)
    Oligomonocytic chronic myelomonocytic leukemia (OM-CMML) is defined as those myelodysplastic syndromes (MDSs) or myelodysplastic/myeloproliferative neoplasms, unclassifiable with relative monocytosis (≥10% monocytes) and ...
  • Optical genome mapping: a promising new tool to assess genomic complexity in chronic lymphocytic leukemia (CLL)
    Puiggros Metje, Anna Maria; Ramos Campoy, Silvia; Kamaso Navarro, Joanna; de la Rosa, Mireia; Salido Galeote, Marta; Melero Vilella, Maria Carme; Rodríguez-Rivera, María; Gimeno Vázquez, Eva; Calvo, Xavier; Arenillas Rocha, Leonor; Ferrer Del Alamo, Ana; Espinet Solà, Blanca (MDPI, 2022)
    Novel treatments in chronic lymphocytic leukemia (CLL) have generated interest regarding the clinical impact of genomic complexity, currently assessed by chromosome banding analysis (CBA) and chromosomal microarray analysis ...
  • Outcomes and molecular profile of oligomonocytic CMML support its consideration as the first stage in the CMML continuum
    Calvo González, Xavier; Roman-Bravo, David; García Gisbert, Nieves, 1994-; Rodriguez-Sevilla, Juan José; García-Avila, Sara; Florensa Brichs, Lourdes; Gibert Fernandez, Joan 1988-; Fernández Rodríguez, M. Concepción; Salido Galeote, Marta; Puiggros Metje, Anna Maria; Espinet Solà, Blanca; Colomo Saperas, Luis Alberto; Bellosillo Paricio, Beatriz; Ferrer, Ana; Arenillas Rocha, Leonor (American Society of Hematology, 2022)
    atients with oligomonocytic chronic myelomonocytic leukemia (OM-CMML) are currently classified according to the 2017 World Health Organization myelodysplastic syndromes classification. However, recent data support considering ...
  • Patients with chronic lymphocytic leukemia and complex karyotype show an adverse outcome even in absence of TP53/ATM FISH deletions
    Puiggros Metje, Anna Maria; Salido Galeote, Marta; Ferrer Del Alamo, Ana; Gimeno Vázquez, Eva; Abella Monreal, Eugenia; Espinet Solà, Blanca (Impact Journals, 2017)
    Genomic complexity identified by chromosome banding analysis (CBA) predicts a worse clinical outcome in CLL patients treated either with standard or new treatments. Herein, we analyzed the clinical impact of complex ...
  • Reduced expansion of CD94/NKG2C + NK cells in chronic lymphocytic leukemia and CLL-like monoclonal B-cell lymphocytosis is not related to increased human cytomegalovirus seronegativity or NKG2C deletions
    Puiggros Metje, Anna Maria; Blanco Ares, Gonzalo, 1989-; Muntasell i Castellví, Aura, 1972-; Rodríguez-Rivera, María; Nonell Mazelón, Lara; Altadill, Mireia; Puigdecanet Riubugent, Eulàlia; Arnal, Magdalena; Calvo, Xavier; Gimeno Vázquez, Eva; Abella Monreal, Eugenia; Abrisqueta, Pau; Bosch José, Francesc Xavier, 1947-; Yélamos López, José; Ferrer, Ana; López-Botet, M. (Miguel); Espinet Solà, Blanca (Wiley, 2021)
    Introduction: Dysregulated NK cell-mediated immune responses contribute to tumor evasion in chronic lymphocytic leukemia (CLL), although the NK cell compartment in CLL-like monoclonal B-cell lymphocytosis (MBL) is poorly ...
  • Restricted T cell receptor repertoire in CLL-like monoclonal B cell lymphocytosis and early stage CLL
    Blanco Ares, Gonzalo, 1989-; Vardi, Anna; Puiggros Metje, Anna Maria; Gómez-Llonín, Andrea; Muro, Manuel; Rodríguez-Rivera, María; Stalika, Evangelia; Abella Monreal, Eugenia; Gimeno Vázquez, Eva; López-Sánchez, Manuela; Senín Magan, Maria Alicia; Calvo, Xavier; Abrisqueta, Pau; Bosch José, Francesc Xavier, 1947-; Ferrer Del Alamo, Ana; Stamatopoulos, Kostas; Espinet Solà, Blanca (Taylor & Francis, 2018)
    Analysis of the T cell receptor (TR) repertoire of chronic lymphocytic leukemia-like monoclonal B cell lymphocytosis (CLL-like MBL) and early stage CLL is relevant for understanding the dynamic interaction of expanded B ...
  • ROS1 copy number alterations are frequent in non-small cell lung cancer
    Clavé Safont, Sergi; Gimeno Beltran, Javier; Muñoz-Mármol, Ana M.; Vidal Barrull, Joana; Reguart, Noemí; Carcereny, Enric; Pijuan Andujar, Lara; Menendez Romero, Silvia; Taus García, Álvaro; Mate, José Luís; Serrano Figueras, Sergi; Albanell Mestres, Joan; Espinet Solà, Blanca; Arriola Aperribay, Edurne; Salido Galeote, Marta (Impact Journals, 2014)
    OBJECTIVES: We aimed to determine the prevalence and partners of ROS1 rearrangements, to explore the correlation between FISH and IHC assays, and to investigate clinical implications of ROS1 copy number alterations (CNAs). ...
  • Thrombotic and bleeding complications in patients with chronic lymphocytic leukemia and severe COVID-19: a study of ERIC, the European Research Initiative on CLL
    Antic, Darko; Espinet Solà, Blanca; Gimeno Vázquez, Eva; Stamatopoulos, Kostas (BioMed Central, 2022)
    Background: Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease ...
  • TP53 Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype
    Ramos Campoy, Silvia; Puiggros Metje, Anna Maria; Kamaso, Joanna; Gimeno Vázquez, Eva; Salido, Marta; Calvo Gonzalo, Xavier; Espinet Solà, Blanca (MDPI, 2022)
    Chromothripsis (cth) has been associated with a dismal outcome and poor prognosis factors in patients with chronic lymphocytic leukemia (CLL). Despite being correlated with high genome instability, previous studies have ...
  • Trisomy 8, a Cytogenetic Abnormality in Myelodysplastic Syndromes, Is Constitutional or Not?
    Saumell, Silvia; Solé Ristol, Francesc; Arenillas Rocha, Leonor; Montoro, Julia; Valcárcel, David; Pedro Olive, Carme; Sanzo, Carmen; Luño, Elisa; Giménez, Teresa; Arnan, Montserrat; Pomares, Helena; De Paz, Raquel; Arrizabalaga, Beatriz; Jerez, Andrés; Martínez, Ana B.; Sánchez-Castro, Judith; Rodríguez-Gambarte, Juan D.; Raya, José M.; Ríos, Eduardo; Rodríguez-Rivera, María; Espinet Solà, Blanca; Florensa Brichs, Lourdes (Public Library of Science, 2015)
    Isolated trisomy 8 is not considered presumptive evidence of myelodysplastic syndrome (MDS) in cases without minimal morphological criteria. One reason given is that trisomy 8 (+8) can be found as a constitutional mosaicism ...
  • Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study
    García-Martín, Paloma; Espinet Solà, Blanca; Rodríguez-Sevilla, Juan José; Blanco Ares, Gonzalo, 1989-; Puiggros Metje, Anna Maria; Sainz, Juan (Nature Research, 2022)