Browsing by Author "Elosua Llanos, Roberto"

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  • Cholesterol and hypertension treatment improve coronary risk prediction but not time-dependent covariates or competing risks
    Subirana Cachinero, Isaac; Camps-Vilaró, Anna; Elosua Llanos, Roberto; Marrugat de la Iglesia, Jaume; Tizón-Marcos, Helena; Palomo, Iván; Dégano, Irene R. (Dove Medical Press, 2022)
    Background and aims: cardiovascular (CV) risk functions are the recommended tool to identify high-risk individuals. However, their discrimination ability is not optimal. While the effect of biomarkers in CV risk prediction ...
  • DNA methylation and gene expression integration in cardiovascular disease
    Palou Márquez, Guillermo; Subirana Cachinero, Isaac; Nonell Mazelón, Lara; Fernández Sanlés, Alba, 1988-; Elosua Llanos, Roberto (BioMed Central, 2021)
    Background: The integration of different layers of omics information is an opportunity to tackle the complexity of cardiovascular diseases (CVD) and to identify new predictive biomarkers and potential therapeutic targets. ...
  • DNA methylation and its relationship with lifestyle, environmental and cardiovascular risk factors
    Sayols Baixeras, Sergi, 1988- (Universitat Pompeu Fabra, 2019-02-25)
    La malaltia cardiovascular, que és primera causa de mortalitat al món, com a fenotip complex depèn tant dels factors ambientals com dels genètics. Les variants genètiques comunes expliquen un 15-20% de l’heretabilitat ...
  • DNA methylation biomarkers of myocardial infarction and cardiovascular disease
    Fernández Sanlés, Alba, 1988-; Sayols Baixeras, Sergi, 1988-; Subirana Cachinero, Isaac; Sentí Clapés, Mariano; Pérez-Fernández, Silvia; Castro de Moura, Manuel; Esteller, Manel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (BioMed Central, 2021)
    Background: The epigenetic landscape underlying cardiovascular disease (CVD) is not completely understood and the clinical value of the identified biomarkers is still limited. We aimed to identify differentially methylated ...
  • DNA methylation of MMPs and TIMPs in atherothrombosis process in carotid plaques and blood tissues
    Gallego-Fabrega, Cristina; Cullell, Natalia; Soriano Tarraga, Carolina; Carrera, Caty; Torres-Aguila, Nuria P.; Muiño, Elena; Cárcel-Márquez, Jara; Castro de Moura, Manuel; Fernández Sanlés, Alba, 1988-; Esteller, Manel; Elosua Llanos, Roberto; Jiménez Conde, Jordi; Roquer, Jaume; Montaner, Joan; Krupinski, Jerzy; Fernández-Cadenas, Israel (Impact Journals, 2020)
    Background and purpose: Polymorphisms and serum levels of Matrix Metalloproteinases (MMP) and Tissue Inhibitor of Metalloproteinases (TIMP) have been studied with regard to atheromatous plaques and ischemic stroke, while ...
  • DNA methylation, cardiovascular risk and myocardial infarction : an epigenome-wide approach
    Fernández Sanlés, Alba, 1988- (Universitat Pompeu Fabra, 2020-01-31)
    Cardiovascular diseases are a major challenge for public health. DNA methylation is a mechanism regulating gene expression, and it is linked to complex diseases and related traits. Therefore, it is a potential source of ...
  • DNA sequence variation in ACVR1C encoding the activin receptor-like kinase 7 influences body fat distribution and protects against type 2 diabetes
    Emdin, Connor A.; Elosua Llanos, Roberto; Kathiresan, Sekar (American Diabetes Association, 2019)
    A genetic predisposition to higher waist-to-hip ratio adjusted for BMI (WHRadjBMI), a measure of body fat distribution, associates with increased risk for type 2 diabetes. We conducted an exome-wide association study of ...
  • Do individuals with autoimmune disease have increased risk of subclinical carotid atherosclerosis and stiffness?
    Vila, M. Mar; Remeseiro, Beatriz; Igual, Laura; Elosua Llanos, Roberto; Ramos, Rafel; Valdivielso, Jose Manuel; Martí-Lluch, Ruth; Marrugat de la Iglesia, Jaume (Nature Research, 2021)
    To explore the role of chronic inflammation inherent to autoimmune diseases in the development of subclinical atherosclerosis and arterial stiffness, this study recruited two population-based samples of individuals with ...
  • Dysfunctional high-density lipoproteins are associated with a greater incidence of acute coronary syndrome in a population at high cardiovascular risk: a nested case-control study
    Soria-Florido, Maria; Castañer, Olga; Lassale, Camille; Elosua Llanos, Roberto; Hernáez, Álvaro; Fitó Colomer, Montserrat (American Hearth Association, 2020)
    Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological ...
  • Early smoking-onset age and risk of cardiovascular disease and mortality
    Fa-Binefa, Manel; Clará Velasco, Alberto; Pérez-Fernández, Silvia; Grau Magaña, Maria; Dégano, Irene R.; Martí-Lluch, Ruth; Ramos, Rafel; Marrugat de la Iglesia, Jaume; Elosua Llanos, Roberto (Elsevier, 2019)
    Early smoking onset age (SOA) is a public health concern with scant empirical evidence of its role in health outcomes. The study had two aims: i) to assess whether an early SOA was associated with the risk of fatal and ...
  • Effectiveness of statins as prevention in people with gout: a population-based cohort study
    Garcia Gil, Maria; Comas Cufí, Marc; Ramos, Rafel; Martí, Ruth; Alves-Cabratosa, Lia; Parramon, Dídac; Prieto-Alhambra, Daniel; Baena Díez, Jose M.; Salvador-González, Betlem; Elosua Llanos, Roberto; Dégano, Irene R.; Marrugat de la Iglesia, Jaume; Grau Magaña, Maria (SAGE Publications, 2019)
    Background: Cardiovascular guidelines do not give firm recommendations on statin therapy in patients with gout because evidence is lacking. Aim: To analyze the effectiveness of statin therapy in primary prevention of ...
  • Epigenomic assessment of cardiovascular disease risk and interactions with traditional risk metrics
    Westerman, Kenneth; Fernández Sanlés, Alba, 1988-; Patil, Prasad; Sebastiani, Paola; Jacques, Paul; Starr, John M.; Deary ,Ian J.; Liu, Qing; Liu, Simi; Elosua Llanos, Roberto; DeMeo, Dawn L; Ordovás, José M. (Wiley-Blackwell, 2020)
    Background Epigenome-wide association studies for cardiometabolic risk factors have discovered multiple loci associated with incident cardiovascular disease (CVD). However, few studies have sought to directly optimize a ...
  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.
    Pattaro, Cristian; Friedrich, Nele; Elosua Llanos, Roberto; Lucas, Gavin, 1977- (Nature Publishing Group, 2016)
    Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular ...
  • Genetic factors associated with coronary heart disease and analysis of their predictive capacity
    Lluís Ganella, Carla, 1984- (Universitat Pompeu Fabra, 2012-06-26)
    The main expansion of the discovery of genetic variants associated with complex diseases has occurred during the last decade. This expansion has been accompanied, and in some sense motivated, by the desire to use this ...
  • Heterozygous ABCG5 gene deficiency and risk of coronary artery disease
    Nomura, Akihiro; Elosua Llanos, Roberto; Kathiresan, Sekar (Lippincott Williams & Wilkins, 2020)
    Background: Familial sitosterolemia is a rare Mendelian disorder characterized by hyperabsorption and decreased biliary excretion of dietary sterols. Affected individuals typically have complete genetic deficiency-homozygous ...
  • High-density lipoprotein characteristics and coronary artery disease: a Mendelian randomization study
    Prats Uribe, Albert; Sayols Baixeras, Sergi, 1988-; Fernández Sanlés, Alba, 1988-; Subirana Cachinero, Isaac; Carreras-Torres, Robert; Vilahur, Gemma; Civeira, Fernando; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Hernáez, Álvaro; Elosua Llanos, Roberto (Elsevier, 2020)
    Background: To assess whether genetically determined quantitative and qualitative HDL characteristics were independently associated with coronary artery disease (CAD). Methods: We designed a two-sample multivariate Mendelian ...
  • Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction
    Lucas, Gavin, 1977-; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Musameh, Muntaser D.; González Ruiz, Juan Ramón; Nelson, Christopher P.; Sentí Clapés, Mariano; Myocardial Infarction Genetics; Wellcome Trust Case Control Constortium; Schwartz, Stephen M; Siscovick, David; O'Donnell, Christopher J; Melander, Olle; Salomaa, Veikko; Purcell, Shaun; Altshuler, David; Samani, Nilesh J.; Kathiresan, Sekar; Elosua Llanos, Roberto (Public Library of Science (PLoS), 2012)
    The genetic loci that have been found by genome-wide association studies to modulate risk of coronary heart disease explain only a fraction of its total variance, and gene-gene interactions have been proposed as a potential ...
  • Identification and validation of seven new loci showing differential DNA methylation related to serum lipid profile: an epigenome-wide approach. The REGICOR study.
    Sayols, Sergi; Subirana Cachinero, Isaac; Lluís Ganella, Carla, 1984-; Civeira, Fernando; Roquer, Jaume; Do, AN; Absher, Devin; Cenarro, A.; Muñoz, Dani; Soriano Tarraga, Carolina; Jiménez Conde, Jordi; Ordovás, José M.; Sentí Clapés, Mariano; Aslibekyan, Stella W.; Marrugat de la Iglesia, Jaume; Arnett, Donna K.; Elosua Llanos, Roberto (Oxford University Press, 2016)
    Lipid traits (total, low-densityand high-density lipoproteincholesterol, and triglycerides) are risk factors for cardiovascular disease. DNA methylation is an inherited but also modifiable epigenetic mark ...
  • Identification of a new locus and validation of previously reported loci showing differential methylation associated with smoking. The REGICOR study.
    Sayols, Sergi; Lluís Ganella, Carla, 1984-; Subirana Cachinero, Isaac; Salas, Lucas A.; Vilahur Chiaraviglio, Nadia, 1982-; Corella, Dolores; Muñoz, Dani; Segura, Antoni, 1952-; Jiménez Conde, Jordi; Moran, Sebastian; Soriano Tarraga, Carolina; Roquer, Jaume; Lopez-Farré, Antonio; Marrugat de la Iglesia, Jaume; Fitó Colomer, Montserrat; Elosua Llanos, Roberto (Taylor & Francis, 2015)
    Smoking increases the risk of many diseases and could act through changes in DNA methylation patterns. The aims of this study were to determine the association between smoking and DNA methylation throughout the genome at ...
  • Identification of a novel locus on chromosome 2q13, which predisposes to clinical vertebral fractures independently of bone density
    Alonso, Nerea; Garcia Giralt, Natàlia; Lucas, Gavin, 1977-; Elosua Llanos, Roberto; Ralston, Stuar (BMJ Publishing Group, 2018)
    OBJECTIVES: To identify genetic determinants of susceptibility to clinical vertebral fractures, which is an important complication of osteoporosis. METHODS: Here we conduct a genome-wide association study in 1553 postmenopausal ...