Browsing by Author "Díez Antón, Juana, 1962-"

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  • Koutsoudakis, George; Romero-Brey, Inés; Berger, Carola; Pérez Vilaró, Gemma, 1985-; Monteiro Perin, Paula; Vondran, Florian Wolfgang Rudolf; Kalesse, Markus; Harmrolfs, Kirsten; Müller, Rolf; Martínez, Javier P.; Pietschmann, Thomas; Bartenschlager, Ralf; Brönstrup, Mark; Meyerhans, Andreas; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human ...
  • Doñate-Macián, Pau; Duarte, Yorley; Rubio Moscardo, Fanny; Pérez Vilaró, Gemma, 1985-; Canan, Jonathan; Díez Antón, Juana, 1962-; González Nilo, Fernando; Valverde, M. A. (Miguel Ángel), 1963- (Wiley, 2022)
    Background and purpose: The transient receptor potential vanilloid 4 (TRPV4) cation channel participates in multiple physiological processes and is also at the core of different diseases, making this channel an interesting ...
  • Campos Mata, Leire de, 1991- (Universitat Pompeu Fabra, 2019-12-18)
    The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation. In this thesis we uncover an unanticipated role of Xrn1 ...
  • Blasco-Moreno, Bernat; de Campos-Mata, Leire; Böttcher, René; García-Martínez, José; Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Chattopadhyay, Shiladitya; Gas, María-Eugenia; Oliva Miguel, Baldomero; Pérez Ortín, José E.; Leidel, Sebastian; Choder, Mordechai; Díez Antón, Juana, 1962- (Nature Research, 2019)
    The highly conserved 5’–3’ exonuclease Xrn1 regulates gene expression in eukaryotes by coupling nuclear DNA transcription to cytosolic mRNA decay. By integrating transcriptome-wide analyses of translation with biochemical ...
  • Talló Parra, Marc, 1992-; Muscolino, Elena; Díez Antón, Juana, 1962- (Frontiers, 2022)
    Viruses completely depend on the host translation machineries to express the viral proteins. Recent data reveal an unprecedented interaction of positive strand RNA ((+)RNA) viruses with the host tRNA epitranscriptome to ...
  • Jungfleisch, Jennifer, 1986-; Chowdhury, Ashis; Alves-Rodrigues, Isabel; Tharun, Sundaresan; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press, 2015)
    The Lsm1-7-Pat1 complex binds to the 3' end of cellular mRNAs and promotes 3' end protection and 5'-3' decay. Interestingly, this complex also specifically binds to cis-acting regulatory sequences of viral positive-strand ...
  • Fleta Soriano, Eric, 1983-; Smutná, Katarína, 1991-; Martinez, Javier P.; Lorca Oró, Cristina; Sadiq, S. Kashif; Mirambeau, Gilles; Lopez-Iglesias, Carmen; Bosch, Marta; Pol, Albert; Brönstrup, Mark; Díez Antón, Juana, 1962-; Meyerhans, Andreas (American Society for Microbiology, 2017)
    Soraphen A is a myxobacterial metabolite that blocks the acetyl-coenzyme A carboxylase of the host and was previously identified as a novel HIV inhibitor. Here, we report that soraphen A acts by reducing virus production ...
  • Doñate-Macián, Pau; Jungfleisch, Jennifer, 1986-; Pérez Vilaró, Gemma, 1985-; Rubio Moscardó, Fanny; Perálvarez Marín, Alex; Díez Antón, Juana, 1962-; Valverde, M. A. (Miguel Ángel), 1963- (Nature Publishing Group, 2018)
    Ion channels are well placed to transduce environmental cues into signals used by cells to generate a wide range of responses, but little is known about their role in the regulation of RNA metabolism. Here we show that the ...
  • Díez Antón, Juana, 1962-; Jungfleisch, Jennifer, 1986- (Taylor & Francis (Routledge), 2017)
    Viruses are powerful tools to uncover cellular processes. Through viral studies we have recently identified a novel translational control mechanism that involves the DEAD-box helicase Dhh1/DDX6 and RNA folding within coding ...
  • Blasco Moreno, Bernat, 1986- (Universitat Pompeu Fabra, 2016-06-03)
    The exonuclease Xrn1 degrades messenger RNAs (mRNAs) and controls transcription. By using a model system that replicates brome mosaic virus (BMV) in yeast, here we show that Xrn1 promotes translation initiation of BMV RNA. ...
  • Blevins, William Robert, 1987-; Ruiz Orera, Jorge, 1988-; Messeguer, Xavier; Blasco Moreno, Bernat, 1986-; Villanueva Cañas, José Luis, 1984-; Espinar, Lorena; Díez Antón, Juana, 1962-; Carey, Lucas, 1980-; Albà Soler, Mar (Nature Research, 2021)
    De novo gene origination has been recently established as an important mechanism for the formation of new genes. In organisms with a large genome, intergenic and intronic regions provide plenty of raw material for new ...
  • Jungfleisch, Jennifer, 1986- (Universitat Pompeu Fabra, 2015-03-20)
    Translation control is a vital aspect of gene expression for both viruses and their cellular hosts. We have previously shown that the cellular mRNA decay activators Dhh1 and Lsm1-7 promote translation of positive-strand ...
  • Jungfleisch, Jennifer, 1986-; Blasco Moreno, Bernat, 1986-; Díez Antón, Juana, 1962- (MDPI, 2016)
    Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this ...
  • Giménez-Barcons, Mireia; Díez Antón, Juana, 1962- (BioMed Central, 2011)
    Processing bodies (PBs) and stress granules (SGs) are two highly conserved cytoplasmic ribonucleoprotein foci that contain translationally repressed mRNAs together with proteins from the mRNA metabolism. Interestingly, ...
  • Palomar Cros, Anna; Díez Antón, Juana, 1962- (2016-09-22)
    Zika virus, a flavivirus transmitted by Aedes mosquitoes, was first identified in 1947 in a sentinel rhesus monkey in the Zika forest area of Uganda, and later on in humans in Nigeria. Despite having been discovered almost ...

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