Browsing by Author "Cozzuto, Luca"

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  • Prp4 kinase grants the license to splice: control of weak splice sites during spliceosome activation
    Eckert, Daniela; Andrée, Nicole; Razanau, Aleh; Zock-Emmenthal, Susanne; Lützelberger, Martin; Plath, Susann; Schmidt, Henning; Guerra Moreno, Ángel; Cozzuto, Luca; Ayté del Olmo, José; Käufer, Norbert F. (Public Library of Science (PLoS), 2016)
    The genome of the fission yeast Schizosaccharomyces pombe encodes 17 kinases that are essential for cell growth. These include the cell-cycle regulator Cdc2, as well as several kinases that coordinate cell growth, polarity, ...
  • QCloud2: an improved cloud-based quality-control system for mass-spectrometry-based proteomics laboratories
    Olivella, Roger; Chiva, Cristina; Serret, Marc; Mancera, Daniel; Cozzuto, Luca; Hermoso Pulido, Antonio; Borràs, Eva; Espadas, Guadalupe; Morales Sanfrutos, Julia; Pastor, Olga; Solé, Amanda; Ponomarenko, Julia; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2021)
    QCloud is a cloud-based system to support proteomics laboratories in daily quality assessment using a user-friendly interface, easy setup, and automated data processing. Since its release, QCloud has facilitated automated ...
  • RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells
    Morey Ramonell, Lluís; Aloia, Luigi; Cozzuto, Luca; Aznar Benitah, Salvador; Di Croce, Luciano (Elsevier, 2013)
    The Polycomb repressive complex 1 (PRC1) is required for decisions of stem cell fate. In mouse embryonic stem cells (ESCs), two major variations of PRC1 complex, defined by the mutually exclusive presence of Cbx7 or RYBP, ...
  • Selective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
    Lu, Lu; Li, Jiarui; Wei, Ranlei; Guidi, Irene; Cozzuto, Luca; Ponomarenko, Julia; Prats-Ejarque, Guillem; Boix, Ester (Springer, 2022)
    RNase2 is the member of the RNaseA family most abundant in macrophages. Here, we knocked out RNase2 in THP-1 cells and analysed the response to Respiratory Syncytial Virus (RSV). RSV induced RNase2 expression, which ...
  • SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML
    Di Mambro, Antonella; Arroyo-Berdugo, Yoana; Fioretti, Tiziana; Randles, Michael; Cozzuto, Luca; Rajeeve, Vinothini; Cevenini, Armando; Austin, Michael J.; Esposito, Grabiella; Ponomarenko, Julia; Lucas, Claire M.; Cutillas, Pedro; Gribben, John; Williams, Owen; Calle, Yolanda; Patel, Bela; Esposito, Maria Teresa (Nature Research, 2023)
    KMT2A-rearranged (KMT2A-R) is an aggressive and chemo-refractory acute leukemia which mostly affects children. Transcriptomics-based characterization and chemical interrogation identified kinases as key drivers of survival ...
  • The altered transcriptome of pediatric myelodysplastic syndrome revealed by RNA sequencing
    Zubovic, Lorena; Piazza, Silvano; Tebaldi, Toma; Cozzuto, Luca; Palazzo, Giuliana; Sidarovich, Viktoryia; Sanctis, Verónica de; Bertorelli, Roberto; Lammens, Tim; Hofmans, Mattias; Moerloose, Bárbara de; Ponomarenko, Julia; Pigazzi, Martina; Masetti, Riccardo; Mecucci, Cristina; Basso, Giuseppe; Macchi, Paolo (BioMed Central, 2020)
    Pediatric myelodysplastic syndrome (PMDS) is a very rare and still poorly characterized disorder. In this work, we identified novel potential targets of PMDS by determining genes with aberrant expression, which can be ...
  • The penile microbiota of Black South African men: relationship with human papillomavirus and HIV infection
    Onywera, Harris; Williamson, Anna-Lise; Cozzuto, Luca; Bonnin, Sarah; Mbulawa, Zizipho Z.A.; Coetzee, David; Ponomarenko, Julia; Meiring, Tracy L. (BioMed Central, 2020)
    Background: To date, the microbiota of the human penis has been studied mostly in connection with circumcision, HIV risk and female partner bacterial vaginosis (BV). These studies have shown that male circumcision reduces ...
  • Zrf1 is required to establish and maintain neural progenitor identity
    Aloia, Luigi; Di Stefano, Bruno, 1984-; Sessa, Alessandro; Morey, Lluis; Santanach, Alexandra; Gutierrez, Arantxa; Cozzuto, Luca; Aznar Benitah, Salvador; Graf, T. (Thomas); Broccoli, Vania; Di Croce, Luciano (Cold Spring Harbor Laboratory Press (CSHL Press), 2014)
    The molecular mechanisms underlying specification from embryonic stem cells (ESCs) and maintenance of neural progenitor cells (NPCs) are largely unknown. Recently, we reported that the Zuotin-related factor 1 (Zrf1) is ...

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