Browsing by Author "Bustamante Pineda, Mariona"

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  • Dose and time effects of solar-simulated ultraviolet radiation on the in vivo human skin transcriptome
    Bustamante Pineda, Mariona; Hernandez-Ferrer, Carles, 1987-; Tewari, Angela; Sarria-Trujillo, Yaris; Harrison, Graham I.; Puigdecanet Riubugent, Eulàlia; Nonell Mazelón, Lara; Kang, W.; Friedländer, Marc R.; Estivill, Xavier, 1955-; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Young, Antony R. (Wiley, 2019)
    BACKGROUND: Terrestrial ultraviolet (UV) radiation causes erythema, oxidative stress, DNA mutations and skin cancer. Skin can adapt to these adverse effects by DNA repair, apoptosis, keratinization and tanning. OBJECTIVES: ...
  • Early-life environmental exposures and molecular markers in children
    Prado Bert, Paula de (Universitat Pompeu Fabra, 2022-10-17)
    L'exposició a factors de risc ambientals durant la vida intrauterina o la infància ha estat relacionada amb un major risc a desenvolupar diverses malalties. Tot i això, els mecanismes biològics subjacents són poc coneguts. ...
  • Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis
    Pires Hartwig, Fernando; Dalmau Bueno, Albert; Guxens Junyent, Mònica; Bustamante Pineda, Mariona; Gomes Victora, Cesar (Oxford University Press, 2019)
    Background: Accumulating evidence suggests that breastfeeding benefits children’s intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, ...
  • Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
    Merid, Simon Kebede; Kogevinas, Manolis; Bustamante Pineda, Mariona; Vrijheid, Martine; Sunyer Deu, Jordi; Antó i Boqué, Josep Maria; Melén, Erik (BioMed Central, 2020)
    Background: Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated ...
  • Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO2 Air Pollution Exposure
    Gruzieva, Olena; Antó i Boqué, Josep Maria; Bustamante Pineda, Mariona; Guxens Junyent, Mònica; Sunyer Deu, Jordi; Melén, Erik (Environmental health perspectives, 2017)
    BACKGROUND: Prenatal exposure to air pollution is considered to be associated with adverse effects on child health. This may partly be mediated by mechanisms related to DNA methylation. OBJECTIVES: We investigated associations ...
  • Gene expression changes in blood RNA after swimming in a chlorinated pool
    Salas, Lucas A.; Font Ribera, Laia; Bustamante Pineda, Mariona; Sumoy Van Dyck, Lauro; Grimalt Obrador, Joan; Bonnin, Sarah; Aguilar Morón, María Asunción; Mattlin, Heidi; Hummel, Manuela; Ferrer Del Alamo, Ana; Kogevinas, Manolis; Villanueva Belmonte, Cristina (Elsevier, 2017)
    Exposure to disinfection by-products (DBP) such as trihalomethanes (THM) in swimming pools has been linked to adverse health effects in humans, but their biological mechanisms are unclear. We evaluated short-term changes ...
  • Gene expression of desaturase (FADS1 and FADS2) and elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children
    Chisaguano, Aida M.; Montes, Rosa; Pérez Berezo, Teresa; Castellote, Ana Isabel; Guerendiain, Marcela; Bustamante Pineda, Mariona; Morales, Eva; García Esteban, Raquel; Sunyer Deu, Jordi; Franch, Àngels; López Sabater, M. Carmen (Public Library of Science (PLoS), 2013)
    Background: It is unknown if changes in the gene expression of the desaturase and elongase enzymes are associated with abnormal n-6 long chain polyunsaturated fatty acid (LC-PUFA) levels in children with atopic eczema (AE). ...
  • Gene-wide association study reveals RNF122 ubiquitin ligase as a novel susceptibility gene for attention deficit hyperactivity disorder
    Garcia Martínez, Iris; Sánchez-Mora, Cristina; Soler Artigas, María; Rovira, Paula; Pagerols, Mireia; Corrales, Montse; Calvo Sánchez, Eva; Richarte, Vanesa; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Cormand, Bru; Casas, Miguel; Ramos Quiroga, Josep Antoni; Ribasés, Marta (Nature Publishing Group, 2017)
    Attention Deficit Hyperactivity Disorder (ADHD) is a common childhood-onset neurodevelopmental condition characterized by pervasive impairment of attention, hyperactivity, and/or impulsivity that can persist into adulthood. ...
  • Genetic and epigenetic regulation of YKL-40 in childhood
    Guerra, Stefano; Sunyer Deu, Jordi; Lavi, Iris; Benet, Marta; Bustamante Pineda, Mariona; Carsin, Anne-Elie; Dobaño, Carlota; Guxens Junyent, Mònica; Tischer, Christina; Vrijheid, Martine; Antó i Boqué, Josep Maria; Koppelman, Gerard H. (Elsevier, 2018)
    Background: Circulating levels of the chitinase-like protein YKL-40 are influenced by genetic variation in its encoding gene (chitinase 3–like 1 [CHI3L1]) and are increased in patients with several diseases, including ...
  • Genetic regulation of newborn telomere length is mediated and modified by DNA methylation
    Wang, Congrong; Alfano, Rossella; Reimann, Brigitte; Hogervorst, Janneke; Bustamante Pineda, Mariona; De Vivo, Immaculata; Plusquin, Michelle; Nawrot, Tim S.; Martens, Dries S. (Frontiers, 2022)
    Telomere length at birth determines later life telomere length and potentially predicts ageing-related diseases. However, the genetic and epigenetic settings of telomere length in newborns have not been analyzed. In addition, ...
  • Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition
    Morales, Eva; Bustamante Pineda, Mariona; González Ruiz, Juan Ramón; Guxens Junyent, Mònica; Torrent Quetglas, Maties; Mendez, Michelle A.; García Esteban, Raquel; Júlvez Calvo, Jordi; Forns i Guzman, Joan, 1981-; Vrijheid, Martine; Molto Puigmarti, Carolina; López Sabater, M. Carmen; Estivill, Xavier, 1955-; Sunyer Deu, Jordi (Public Library of Science (PLoS), 2011)
    Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes ...
  • Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
    Morales, Eva; Vilahur Chiaraviglio, Nadia, 1982-; Salas Díaz, Lucas Andrés, 1980-; Motta, Valeria; Fernandez, Mariana F.; Murcia, Mario; Llop, Sabrina; Tardón, Adonina; Fernandez-Tardon, Guillermo; Santa Marina, Loreto; Gallastegui, Mara; Bollati, Valentina; Estivill, Xavier, 1955-; Olea, Nicolás; Sunyer Deu, Jordi; Bustamante Pineda, Mariona (Oxford University Press, 2016)
    BACKGROUND: We conducted an epigenome-wide association study (EWAS) of DNA methylation in placenta in relation to maternal tobacco smoking during pregnancy and examined whether smoking-induced changes lead to low birthweight. ...
  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
    Min, Josine L.; Soriano Tarraga, Carolina; Giralt-Steinhauer, Eva; Ruiz Arenas, Carlos, 1990-; Jiménez Conde, Jordi; Roquer, Jaume; González, Juan Ramón; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Relton, Caroline (Nature Research, 2021)
    Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait ...
  • Green spaces, excess weight and obesity in Spain
    O'Callaghan Gordo, Cristina; Espinosa, Aina; Valentin, Antonia; Tonne, Cathryn; Castaño Vinyals, Gemma; Cirach, Marta; Bustamante Pineda, Mariona; Nieuwenhuijsen, Mark J.; Kogevinas, Manolis (Elsevier, 2020)
    Background: The epidemiological evidence on green spaces and obesity is inconsistent. Objectives: To study the association of access to green spaces and surrounding greenness with obesity in Spain. Methods: We enrolled ...
  • Human Early Life Exposome (HELIX) study: a European population-based exposome cohort
    Maitre, Léa; De Bont, Jeroen, 1989-; Casas Sanahuja, Maribel; Robinson, Oliver; Basagaña Flores, Xavier; Borràs, Eva; Bustamante Pineda, Mariona; de Castro, Montserrat; Donaire González, David; Estivill, Xavier, 1955-; Fossati, Serena; González, Juan Ramón; Hernández-Ferrer, Carles; Júlvez Calvo, Jordi; Manzano Salgado, Cyntia Beatriz, 1987-; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Tamayo-Uria, Ibon; Urquiza, José M.; van Gent, Diana; Vives Usano, Marta, 1990-; Warembourg, Charline; Nieuwenhuijsen, Mark J.; Vrijheid, Martine (BMJ Publishing Group, 2018)
    PURPOSE: Essential to exposome research is the collection of data on many environmental exposures from different domains in the same subjects. The aim of the Human Early Life Exposome (HELIX) study was to measure and ...
  • The Human Early-Life Exposome (HELIX): project rationale and design
    Vrijheid, Martine; Robinson, Oliver; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; van Gent, Diana; González Ruiz, Juan Ramón; Júlvez Calvo, Jordi; Kogevinas, Manolis; Sabidó Aguadé, Eduard, 1981-; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2014)
    Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure–health effect relationships. The ...
  • Identification of autosomal cis expression quantitative trait methylation (cis eQTMs) in children's blood
    Ruiz-Arenas, Carlos; Hernandez-Ferrer, Carles, 1987-; Vives Usano, Marta, 1990-; Marí, Sergi; Casas Sanahuja, Maribel; Vafeiadi, Marina, 1983-; Vrijheid, Martine; González Ruiz, Juan Ramón; Bustamante Pineda, Mariona (eLife Sciences Publications, 2022)
    Background: The identification of expression quantitative trait methylation (eQTMs), defined as associations between DNA methylation levels and gene expression, might help the biological interpretation of epigenome-wide ...
  • In utero and childhood exposure to tobacco smoke and multi-layer molecular signatures in children
    Vives Usano, Marta, 1990-; Hernández-Ferrer, Carles; Maitre, Léa; Ruiz Arenas, Carlos, 1990-; Borràs, Eva; Casas Sanahuja, Maribel; Estivill, Xavier, 1955-; González, Juan Ramón; Sabidó Aguadé, Eduard, 1981-; Vrijheid, Martine; Bustamante Pineda, Mariona (BioMed Central, 2020)
    Background: The adverse health effects of early life exposure to tobacco smoking have been widely reported. In spite of this, the underlying molecular mechanisms of in utero and postnatal exposure to tobacco smoke are only ...
  • In utero exposure to mixtures of xenoestrogens and child neuropsychological development
    Vilahur Chiaraviglio, Nadia, 1982-; Fernandez, Mariana F.; Bustamante Pineda, Mariona; Ramos, Rosa; Forns i Guzman, Joan, 1981-; Ballester Díez, Ferran; Murcia, Mario; Riaño, Isolina; Ibarluzea, Jesús; Olea, Nicolás; Sunyer Deu, Jordi (Elsevier, 2014)
    BACKGROUND: To date, no epidemiological studies have explored the impact and persistence of in utero exposure to mixtures of xenoestrogens on the developing brain. We aimed to assess whether the cumulative effect of ...
  • Integration of gene expression and DNA methylation identifies epigenetically controlled modules related to PM2.5 exposure
    Merid, Simon Kebede; Bustamante Pineda, Mariona; Standl, Marie; Sunyer Deu, Jordi; Heinrich, Joachim; Lemonnier, Nathanael; Aguilar, Daniel; Antó i Boqué, Josep Maria; Bousquet, Jean; Santa Marina, Loreto; Lertxundi, Aitana; Bergström, Anna; Kull, Inger; Wheelock, Åsa M.; Koppelman, Gerard H.; Melén, Erik; Gruzieva, Olena (Elsevier, 2020)
    Air pollution has been associated with adverse health effects across the life-course. Although underlying mechanisms are unclear, several studies suggested pollutant-induced changes in transcriptomic profiles. In this ...