Browsing by Author "Blanco, Enrique"

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  • The bivalent genome: characterization, structure, and regulation
    Blanco, Enrique; González Ramírez, Mar, 1991-; Alcaine Colet, Anna, 1992-; Aranda Aragón, Sergio; Di Croce, Luciano (Elsevier, 2020)
    An intricate molecular machinery is at the core of gene expression regulation in every cell. During the initial stages of organismal development, the coordinated activation of diverse transcriptional programs is crucial ...
  • The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity
    Santanach Buxaderas, Alexandra, 1988-; Blanco, Enrique; Jiang, Hua; Molloy, Kelly R.; Sansó Martínez, Miriam, 1979-; LaCava, John; Morey Ramonell, Lluís; Di Croce, Luciano (Nature Publishing Group, 2017)
    Polycomb group proteins (PcG) are transcriptional repressors that control cell identity and development. In mammals, five different CBX proteins associate with the core Polycomb repressive complex 1 (PRC1). In mouse embryonic ...
  • The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation
    Vizán, Pedro; Gutiérrez, Arantxa; Espejo, Isabel; García Montolío, Marc, 1991-; Lange, Martin; Carretero, Ana; Lafzi, Atefeh; Andrés Aguayo, Luisa de; Blanco, Enrique; Thambyrajah, Roshana; Graf, T. (Thomas); Heyn, Holger; Bigas Salvans, Anna; Di Croce, Luciano (American Association for the Advancement of Science (AAAS), 2020)
    Adult hematopoietic stem cells (HSCs) are rare multipotent cells in bone marrow that are responsible for generating all blood cell types. HSCs are a heterogeneous group of cells with high plasticity, in part, conferred by ...
  • Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy
    Martone, Julie; Lisi, Michela; Castagnetti, Francesco; Rosa, Alessandro; Di Carlo, Valerio; Blanco, Enrique; Setti, Adriano; Mariani, Davide; Colantoni, Alessio; Santini, Tiziana; Perone, Lucia; Di Croce, Luciano; Bozzoni, Irene (Wiley Open Access, 2020)
    Exon skipping is an effective strategy for the treatment of many Duchenne Muscular Dystrophy (DMD) mutations. Natural exon skipping observed in several DMD cases can help in identifying novel therapeutic tools. Here, we ...
  • Transcription factor map alignment of promoter regions
    Blanco, Enrique; Messeguer, Xavier; Smith, Temple F.; Guigó Serra, Roderic (Public Library of Science (PLoS), 2006)
    We address the problem of comparing and characterizing the promoter regions of genes with similar expression patterns. This remains a challenging problem in sequence analysis, because often the promoter regions of co-expressed ...
  • Use of ChIP-Seq data for the design of a multiple promoter-alignment method
    Erb, Ionas; González-Vallinas Rostes, Juan, 1983-; Bussotti, Giovanni, 1983-; Blanco, Enrique; Eyras Jiménez, Eduardo; Notredame, Cedric (Oxford University Press, 2012)
    We address the challenge of regulatory sequence alignment with a new method, Pro-Coffee, a multiple aligner specifically designed for homologous promoter regions. Pro-Coffee uses a dinucleotide substitution matrix estimated ...