Browsing by Author "Bellosillo Paricio, Beatriz"

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  • Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea
    Alvarez-Larrán, Alberto; Díaz-González, Alvaro; Such, Esperanza; Mora, Elvira; Andrade-Campos, Marcio; García-Hernández, Carmen; Gómez-Casares, Maria-Teresa; García-Gutiérrez, Valentín; Carreño-Tarragona, Gonzalo; Garrote, Marta; Fernández-Ibarrondo, Lierni; Cervera, José; Bellosillo Paricio, Beatriz; Cervantes, Francisco; Hernández-Boluda, Juan Carlos; MPN Spanish Group (GEMFIN) (Nature Research, 2020)
  • HER-family ligands promote acquired resistance to trastuzumab in gastric cancer
    Sampera Borràs, Aïda, 1990-; Sánchez-Martín, Francisco Javier; Arpí Llucià, Oriol; Visa Turmo, Laura; Iglesias Coma, Mar; Menéndez, Silvia; Gaye, Élisabeth; Dalmases Massegú, Alba, 1982-; Clavé Safont, Sergi; Gelabert-Baldrich, Mariona; Tuxen Poulsen, Thomas; Kragh, Michael; Bellosillo Paricio, Beatriz; Albanell Mestres, Joan; Rovira Guerín, Ana; Rovira Guerín, Ana; Montagut Viladot, Clara (American Association for Cancer Research (AACR), 2019)
    Despite the clinical benefit of trastuzumab, eventually all HER2-amplified gastric cancer tumors develop drug resistance. We aimed to identify molecular mechanisms of acquired resistance to trastuzumab in gastric cancer ...
  • High accuracy of a blood ctDNA-based multimodal test to detect colorectal cancer
    Bessa Caserras, Xavier; Vidal Barrull, Joana; Balboa, J. C.; Márquez, Carmen; Duenwald, Sven J.; He, Y.; Raymond, Victoria M.; Faull, Iris; Burón, Andrea; Álvarez-Urturi, Cristina; Castells, Xavier; Bellosillo Paricio, Beatriz; Montagut Viladot, Clara (Elsevier, 2023)
    Background: Detection of circulating tumor DNA (ctDNA) is a minimally invasive and convenient blood-based screening strategy that may increase effectiveness of colorectal cancer (CRC) screening. Patients and methods: A ...
  • Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.
    Robles, Eloy F.; Bellosillo Paricio, Beatriz; Salar Silvestre, Antonio; Martinez-Climent, Jose A. (Nature Publishing Group, 2016)
    NKX2 homeobox family proteins have a role in cancer development. Here we show that NKX2-3 is overexpressed in tumour cells from a subset of patients with marginal-zone lymphomas, but not with other B-cell malignancies. ...
  • Identification of ALK gene alterations in urothelial carcinoma
    Bellmunt Molins, Joaquim, 1959-; Selvarajah, Shamini; Rodig, Scott; Salido Galeote, Marta; Muga, Silvia de; Costa, Irmgard; Bellosillo Paricio, Beatriz; Werner, Lillian; Mullane, Stephanie A.; Fay, André P.; O’Brien, Robert; Barretina, Jordi; Minoche, André E.; Signoretti, Sabina; Montagut Viladot, Clara; Himmelbauer, Heinz; Berman, David M.; Kantoff, Philip; Choueiri, Toni K.; Rosenberg, Jonathan E. (Public Library of Science (PLoS), 2014)
    Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers. Currently, there is no information about ALK gene alterations in ...
  • Identification of two novel EPOR gene variants in primary familial polycythemia: Case report and literature review
    Lo Riso, Laura; Vargas-Parra, Gardenia; Navarro, Gemma; Arenillas Rocha, Leonor; Fernández-Ibarrondo, Lierni; Robredo, Beatriz; Ballester, Carmen; López, Bernardo; Perez-Montaña, Albert; Sampol, Antonia; Florensa Brichs, Lourdes; Besses Raebel, Carles; Duran, María Antonia; Bellosillo Paricio, Beatriz (MDPI, 2022)
    Primary familial and congenital polycythemia is a rare disease characterized by an increase in red cell mass that may be due to pathogenic variants in the EPO receptor (EPOR) gene. To date, 33 genetic variants have been ...
  • Immune checkpoint inhibitor treatment in patients with oncogene- addicted non-small cell lung cancer (NSCLC): summary of a multidisciplinary round-table discussion
    Berghoff, Anna S.; Bellosillo Paricio, Beatriz; Caux, Christophe; de Langen, Adrianus; Mazieres, Julien; Normanno, Nicola; Preusser, Matthias; Provencio, Mariano; Rojo, Federico; Wolf, Jurgen; Zielinski, Christoph C. (BMJ Publishing Group, 2019)
    The introduction of targeted treatments and more recently immune checkpoint inhibitors (ICI) to the treatment of metastatic non-small cell lung cancer (NSCLC) has dramatically changed the prognosis of selected patients. ...
  • Impact of genotype on leukaemic transformation in polycythaemia vera and essential thrombocythaemia
    Alvarez-Larrán, Alberto; Senín Magan, Maria Alicia; Fernández Rodríguez, M. Concepción; Pereira, Arturo; Arellano-Rodrigo, Arturo; Gómez, Montse; Ferrer-Marín, Francisca; Martínez-López, Joaquín; Camacho Díaz, Laura; Colomer Pujol, Dolors; Angona Figueras, Anna; Navarro, Blanca; Cervantes, Francisco; Besses Raebel, Carles; Bellosillo Paricio, Beatriz; Hernández-Boluda, Juan Carlos (Wiley, 2017)
    The influence of driver mutations on leukaemic transformation was analysed in 1747 patients with polycythaemia vera or essential thrombocythaemia. With a median follow-up of 7·2 years, 349 patients died and 62 progressed ...
  • Improving molecular diagnosis in myeloid neoplasms : The role of cell-free DNA
    García Gisbert, Nieves (2022-03-09)
    Myeloid malignancies are clonal diseases originated in myeloid hematopoietic stem cells that are frequently initiated by somatic mutations. The detection of genetic alterations has considerably improved the diagnostic ...
  • In silico validation of RNA-Seq results can identify gene fusions with oncogenic potential in glioblastoma
    Hernandez, Ainhoa; Muñoz-Mármol, Ana M.; Esteve-Codina, Anna; Alameda Quitllet, Francisco; Carrato, Cristina; Pineda, Estela; Arpí Llucià, Oriol; Martinez-García, Maria; Mallo, Mar; Gut, Marta; Barco Berrón, Sonia del; Gallego, Oscar; Dabad, Marc; Mesia, Carlos; Bellosillo Paricio, Beatriz; Domenech, Marta; Vidal, Noemí; Aldecoa, Iban; Iglesia, Nuria de la; Balana, Carmen (Nature Research, 2022)
    RNA-Sequencing (RNA-Seq) can identify gene fusions in tumors, but not all these fusions have functional consequences. Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in ...
  • International external quality assurance of JAK2 V617F quantification
    Asp, Julia; Bellosillo Paricio, Beatriz; Pallisgaard, Niels (SpringerOpen, 2019)
    External quality assurance (EQA) programs are vital to ensure high quality and standardized results in molecular diagnostics. It is important that EQA for quantitative analysis takes into account the variation in methodology. ...
  • Leukemic involvement is a common feature in waldenström macroglobulinemia at diagnosis
    Montesdeoca, Sara; García Gisbert, Nieves, 1994-; Calvo, Xavier; Arenillas Rocha, Leonor; Román, David; Fernández Rodríguez, M. Concepción; Navarro, Rosa; Costan, Beatriz; Vela Ortíz, María del Carmen; Camacho Díaz, Laura; Abella Monreal, Eugenia; Colomo Saperas, Luis Alberto; Salido Galeote, Marta; Puiggros Metje, Anna Maria; Florensa Brichs, Lourdes; Espinet Solà, Blanca; Bellosillo Paricio, Beatriz; Ferrer del Álamo, Anna (MDPI, 2023)
    Waldenström Macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with bone marrow (BM) involvement and IgM monoclonal gammopathy. To date, no studies have focused specifically on peripheral blood (PB) involvement. In ...
  • Liquid biopsy in oncology: a consensus statement of the Spanish Society of Pathology and the Spanish Society of Medical Oncology
    Remon, Jordi; García-Campelo, Rosario; Álava, Enrique de; Vera, R.; Rodríguez Peraltó, José Luís; Rodríguez-Lescure, Álvaro; Bellosillo Paricio, Beatriz; Garrido, P.; Rojo, Federico; Álvarez-Alegret, R. (Springer, 2020)
    The proportion of cancer patients with tumours that harbour a potentially targetable genomic alteration is growing considerably. The diagnosis of these genomic alterations can lead to tailored treatment at the onset of ...
  • Long-term follow-up of recovered MPN patients with COVID-19
    Barbui, Tiziano; Andrade-Campos, Marcio; Bellosillo Paricio, Beatriz; Rambaldi, Alessandro (Nature Research, 2021)
  • Low-risk polycythemia vera treated with phlebotomies: clinical characteristics, hematologic control and complications in 453 patients from the Spanish Registry of Polycythemia Vera
    Triguero, Ana; Vélez, Patricia; Bellosillo Paricio, Beatriz; MPN Spanish Group (GEMFIN) (Springer, 2022)
    Hematological control, incidence of complications, and need for cytoreduction were studied in 453 patients with low-risk polycythemia vera (PV) treated with phlebotomies alone. Median hematocrit value decreased from 54% ...
  • Machine learning improves risk stratification in myelofibrosis: An analysis of the spanish registry of myelofibrosis
    Mosquera Orgueira, Adrián; Vélez, Patricia; Bellosillo Paricio, Beatriz; Hernández-Boluda, Juan Carlos (Wolters Kluwer (LWW), 2022)
    Myelofibrosis (MF) is a myeloproliferative neoplasm (MPN) with heterogeneous clinical course. Allogeneic hematopoietic cell transplantation remains the only curative therapy, but its morbidity and mortality require careful ...
  • Masked polycythaemia vera: presenting features, response to treatment and clinical outcomes.
    Álvarez Larrán, Alberto; Angona Figueras, Anna; Ancochea Serra, Agueda; García-Pallarols, Francesc; Fernández Rodríguez, M. Concepción; Longarón Rozalen, Raquel; Bellosillo Paricio, Beatriz; Besses Raebel, Carles (Wiley, 2016)
    Masked polycythaemia vera (PV) has been proposed as a new entity with poorer outcome than overt PV. In this study, the initial clinical and laboratory characteristics, response to treatment and outcome of masked and overt ...
  • MicroRNAs 142-3p, miR-155 and miR-203 are deregulated in gastric MALT LymphomasCompared to chronic gastritis
    Fernández Rodríguez, M. Concepción; Bellosillo Paricio, Beatriz; Ferraro Rosset, Mariana Paola; Seoane, Agustín; Sanchez Gonzalez, Blanca; Pairet García, Silvia; Pons, A.; Barranco Sanz, Luis Carlos; Vela Ortíz, María del Carmen; Gimeno Vázquez, Eva; Colomo Saperas, Luis Alberto; Besses Raebel, Carles; Navarro, Alfons; Salar Silvestre, Antonio (International Institute of Anticancer Research (IIAR), 2017)
    BACKGROUND: Over the last years, our knowledge on pathogenesis of gastric MALT lymphoma has greatly improved, but its morphological diagnosis is still hampered by overlapping histological features with advanced chronic ...
  • miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia.
    Navarro, A.; Pairet García, Silvia; Álvarez Larrán, Alberto; Pons, A.; Ferrer, G.; Longarón Rozalen, Raquel; Fernández Rodríguez, M. Concepción; Camacho Díaz, Laura; Monzó, M.; Besses Raebel, Carles; Bellosillo Paricio, Beatriz (Nature Publishing Group, 2016)
    The biological basis of essential thrombocythemia (ET) patients lacking known mutations is still unknown. MicroRNAs (miRNA) regulate hematopoietic differentiation and are deregulated in several hematopoietic malignancies. ...
  • Molecular and cytogenetic characterization of myelodysplastic syndromes in cell-free DNA
    García Gisbert, Nieves, 1994-; Garcia-Ávila, Sara; Merchán, Brayan; Salido Galeote, Marta; Fernández Rodríguez, M. Concepción; Gibert Fernandez, Joan 1988-; Fernández-Ibarrondo, Lierni; Camacho Díaz, Laura; Lafuente, Marta; Longarón Rozalen, Raquel; Espinet Solà, Blanca; Vélez, Patricia; Pujol Vallverdú, Ramon Maria; Andrade-Campos, Marcio; Arenillas Rocha, Leonor; Salar Silvestre, Antonio; Calvo Gonzalo, Xavier; Besses Raebel, Carles; Bellosillo Paricio, Beatriz (American Society of Hematology, 2022)
    Molecular and cytogenetic studies are essential for diagnosis and prognosis in patients with myelodysplastic syndromes (MDSs). Cell-free DNA (cfDNA) analysis has been reported to be a reliable noninvasive approach for ...

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