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Browsing by Author "Beato, Miguel"
Now showing items 21-40 of 44
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Pohl, Andy, 1979- (Universitat Pompeu Fabra, 2014-10-03)Genome-wide analysis of the nucleosome positioning and histone H1 isoform content of the T47D breast cancer cell line has found a number of observations, namely that with a gentle digestion of microccocal nuclease (MNase), ...
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Ballaré, Cecilia Julia; Castellano, Giancarlo; Gaveglia, Laura; Althammer, Sonja Daniela; González-Vallinas Rostes, Juan, 1983-; Eyras Jiménez, Eduardo; Le Dily, François; Zaurín Quer, Roser; Soronellas, Daniel; Vicent, Guillermo Pablo; Beato, Miguel (Elsevier, 2013)In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by ...
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Vidal Ocabo, Enrique; Le Dily, François; Quilez Oliete, Javier; Stadhouders, Ralph; Cuartero, Yasmina; Graf, T. (Thomas); Martí Renom, Marc A.; Beato, Miguel; Filion, Guillaume (Oxford University Press, 2018)The three-dimensional conformation of genomes is an essential component of their biological activity. The advent of the Hi-C technology enabled an unprecedented progress in our understanding of genome structures. However, ...
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Miñana Gómez, Belén (Universitat Pompeu Fabra, 2008-03-06)Para avanzar en el entendimiento de las vías de señalización moleculares involucradas en la progresión de cáncer tumoral, se construyo una plataforma personalizada de cDNAs, la cual contiene genes de vías de señalización ...
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Beato, Miguel; Sharma, Priyanka (MDPI, 2020)Protein arginine deimination leading to the non-coded amino acid citrulline remains a key question in the field of post-translational modifications ever since its discovery by Rogers and Simmonds in 1958. Citrullination ...
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Althammer, Sonja Daniela; González-Vallinas Rostes, Juan, 1983-; Ballaré, Cecilia Julia; Beato, Miguel; Eyras Jiménez, Eduardo (Oxford University Press, 2011)MOTIVATION: High-throughput sequencing (HTS) has revolutionized gene regulation studies and is now fundamental for the detection of protein-DNA and protein-RNA binding, as well as for measuring RNA expression. With increasing ...
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Amat, Ramon; Böttcher, René; Le Dily, François; Vidal Ocabo, Enrique; Quilez Oliete, Javier; Cuartero, Yasmina; Beato, Miguel; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)Nuclear architecture is decisive for the assembly of transcriptional responses. However, how chromosome organization is dynamically modulated to permit rapid and transient transcriptional changes in response to environmental ...
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Iannone, Camilla, 1984-; Pohl, Andy, 1979-; Papasaikas, Panagiotis; Soronellas, Daniel; Vicent, Guillermo Pablo; Beato, Miguel; Valcárcel, J. (Juan) (Cold Spring Harbor Laboratory Press, 2015)Splicing of mRNA precursors can occur cotranscriptionally and it has been proposed that chromatin structure influences splice site recognition and regulation. Here we have systematically explored potential links between ...
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Sancho Medina, Mónica (Universitat Pompeu Fabra, 2008-05-30)At least eleven histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition of playing a structural ...
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Wierer, Michael, 1982- (Universitat Pompeu Fabra, 2013-01-13)Steroid receptors (SRs) are hormone-induced transcription factors that regulate gene expression by their concerted actions with coregulatory proteins. Performing a quantitative mass spectrometry-based interaction screen ...
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Wright, Roni H.G.; Beato, Miguel (MDPI, 2021)Despite global research efforts, breast cancer remains the leading cause of cancer death in women worldwide. The majority of these deaths are due to metastasis occurring years after the initial treatment of the primary ...
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Calvo Vidal, Verónica Alejandra (Universitat Pompeu Fabra, 2009-07-17)Germ-line mutations in the breast cancer susceptibility gene BRCA1 strongly increase the risk of developing breast and ovarian cancer in women. Different hypothesis have been proposed to explain this tissue specificity. ...
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Zaurín Quer, Roser (Universitat Pompeu Fabra, 2009-07-16)Evidències recents han remarcat la importància del paper de l'estructura de la cromatina i el posicionament de nucleosomes en processos cel·lulars bàsics com és la regulació de la transcripció gènica. L'avenç de noves ...
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Le Dily, François; Beato, Miguel (MDPI, 2018)Initial studies showed that ligand-activated hormone receptors act by binding to the proximal promoters of individual target genes. Genome-wide studies have now revealed that regulation of transcription by steroid hormones ...
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Muñoz-Gil, Gorka; Romero-Aristizabal, Catalina; Mateos, Nicolas; Campelo, Felix; De Llobet, Lara Isabel; Beato, Miguel; Lewenstein, Maciej; Garcia-Parajo, Maria F.; Torreno-Pina, Juan A. (National Academy of Sciences, 2022)Liquid-liquid phase separation (LLPS) is emerging as a key physical principle for biological organization inside living cells, forming condensates that play important regulatory roles. Inside living nuclei, transcription ...
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Nikolaou, Christoforos; Althammer, Sonja Daniela; Beato, Miguel; Guigó Serra, Roderic (BioMed Central, 2010)BACKGROUND: Recent advances in the field of high-throughput genomics have rendered possible the performance of genome-scale studies to define the nucleosomal landscapes of eukaryote genomes. Such analyses are aimed towards ...
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Beato, Miguel; Giráldez, Fernando; Pujades Corbi, Cristina; Bertranpetit, Jaume, 1952- (2014-04-03)
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Page, Brent D.G.; Wright, Roni H.G.; Font Mateu, Jofre, 1977-; Beato, Miguel; Helleday, Thomas (Nature Research, 2018)With a diverse network of substrates, NUDIX hydrolases have emerged as a key family of nucleotide-metabolizing enzymes. NUDT5 (also called NUDIX5) has been implicated in ADP-ribose and 8-oxo-guanine metabolism and was ...
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Ferrari, Roberto; De Llobet, Lara Isabel; Di Vona, Chiara, 1981-; Le Dily, François; Vidal Ocabo, Enrique; Lloutas, Antonios; Quilez Oliete, Javier; Jochem, Laura; Cuts, Erin; Dieci, Giorgio; Vannini, Alessandro; Teichmann, Martin; de la Luna, Susana; Beato, Miguel (Elsevier, 2020)How repetitive elements, epigenetic modifications, and architectural proteins interact ensuring proper genome expression remains poorly understood. Here, we report regulatory mechanisms unveiling a central role of Alu ...
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Qi, Hongyun; Wright, Roni H.G.; Beato, Miguel; Price, Brendan D. (Elsevier, 2022)DNA damage leads to rapid synthesis of poly(ADP-ribose) (pADPr), which is important for damage signaling and repair. pADPr chains are removed by poly(ADP-ribose) glycohydrolase (PARG), releasing free mono(ADP-ribose) ...
Now showing items 21-40 of 44
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