Browsing by Author "Andreu Martínez, David"

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  • Salazar, Vivian A.; Arranz-Trullén, Javier; Prats-Ejarque, Guillem; Torrent, Marc; Andreu Martínez, David; Pulido, David; Boix, Ester (MDPI, 2019)
    Candida albicans is a polymorphic fungus responsible for mucosal and skin infections. Candida cells establish themselves into biofilm communities resistant to most currently available antifungal agents. An increase of ...
  • Andreu Martínez, David; Freire, Joao Miguel; Veiga, Anna; Conceiçao, Thaís M.; Kowalczyk, Wioleta; Mohana-Borges, Ronaldo; Santos, Nuno C.; Da Poian, Andrea T.; Castanho, Miguel A.R.B. (Public Library of Science (PLoS), 2014)
    Supercharged proteins are a recently identified class of proteins that have the ability to efficiently deliver functional macromolecules into mammalian cells. They were first developed as bioengineering products, but were ...
  • Defaus, Sira; Avilés, Manuel; Andreu Martínez, David; Gutiérrez Gallego, Ricardo, 1968- (MDPI, 2018)
    Seminal plasma proteins are relevant for sperm functionality and some appear responsible for establishing sperm interactions with the various environments along the female genital tract towards the oocyte. In recent years, ...
  • Martín-Sánchez, Fátima; Martínez-García, Juan José; Muñoz-García, María; Martínez-Villanueva, Miriam; Noguera-Velasco, José A.; Andreu Martínez, David; Rivas, Luis; Pelegrín, Pablo (Springer Nature, 2017)
    The nucleotide-binding domain and leucine-rich repeat-containing receptor with a pyrin domain 3 (NLRP3) inflammasome is a sensor for different types of infections and alterations of homeostatic parameters, including ...
  • Rivas, Luis; Luque Ortega, Juan Román; Fernández Reyes, María; Andreu Martínez, David (De Gruyter, 2010)
    The lipid components of pathogen cell membranes have been considered as a poor pharmacological target, due to their universal distribution and apparent homogeneity throughout living organisms. Among the rare exceptions to ...
  • Rodrigues, Margarida; Santos, Andrea; Torre, Beatriz G. de la; Rádis Baptista, Gandhi; Andreu Martínez, David; Santos, Nuno C. (Elsevier, 2012)
    A novel class of cell-penetrating, nucleolar-targeting peptides (NrTPs), was recently developed from the rattlesnake venom toxin crotamine. Based on the intrinsic fluorescence of tyrosine or tryptophan residues, the partition ...
  • Freire, Joao Miguel; Gaspar, Diana; García de la Torre, Beatriz; Veiga, Ana Salomé; Andreu Martínez, David; Castanho, Miguel A.R.B. (Elsevier, 2015)
    Despite the intensive study of antibiotic-induced bacterial permeabilization, its kinetics and molecular mechanism remain largely elusive. A new methodology that extends the concept of the live-dead assay in flow cytometry ...
  • Villanueva Cañas, José Luis, 1984-; Ruiz Orera, Jorge, 1988-; Agea, M. Isabel; Gallo, Maria; Andreu Martínez, David; Albà Soler, Mar (Oxford University Press, 2017)
    The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected ...
  • Dias, Susana A.; Freire, Joao Miguel; Pérez-Peinado, Clara; Domingues, Marco M.; Gaspar, Diana; Vale, Nuno; Gomes, Paula; Andreu Martínez, David; Henriques, Sónia T.; Castanho, Miguel A.R.B.; Veiga, Ana Salomé (Frontiers, 2017)
    The increasing prevalence of multidrug-resistant bacteria urges the development of new antibacterial agents. With a broad spectrum activity, antimicrobial peptides have been considered potential antibacterial drug leads. ...
  • García Mayoral, María Flor; Moussaoui, Mohammed; Torre, Beatriz G. de la; Andreu Martínez, David; Boix, Ester; Nogués, Victòria M; Rico, Manuel; Laurents, Douglas V.; Bruix, Marta (Elsevier, 2010)
    Eosinophil cationic protein (ECP) is a highly stable, cytotoxic ribonuclease with the ability to enter and disrupt membranes that participates in innate immune defense against parasites but also kills human cells. We have ...
  • González Magaldi, Mónica; Vázquez Calvo, Ángela; Torre, Beatriz G. de la; Valle, Javier; Andreu Martínez, David; Sobrino, Francisco (Public Library of Science (PLoS), 2015)
    Nonstructural protein 3A is involved in relevant functions in foot-and-mouth disease virus (FMDV) replication. FMDV 3A can form homodimers and preservation of the two hydrophobic α-helices (α1 and α2) that stabilize the ...
  • Rodríguez Falcón, Manuel (Universitat Pompeu Fabra, 2010-10-07)
    Normally present in water, soil and waste water, Acinetobacter baumannii has become an important nosocomial pathogen, as causal agent of pneumonias, septicemias and urinary tract infections, among other complications in ...
  • Soto-Iglesias, David; Duchateau, Nicolas; Butakoff, Constantine; Andreu Martínez, David; Fernández-Armenta, Juan; Bijnens, Bart; Berruezo Sánchez, Antonio; Sitges, Marta; Camara, Oscar (Institute of Electrical and Electronics Engineers (IEEE), 2017)
    Electro-anatomical maps (EAMs) are commonly acquired in clinical routine for guiding ablation therapies. They provide voltage and activation time information on a 3-D anatomical mesh representation, making them useful for ...
  • Martinez, Javier P.; Lisa, Silvia; Sánchez, Rosa; Kowalczyk, Wioleta; Zurita, Esther; Teixidó, Meritxell; Giralt, Ernest; Andreu Martínez, David; Avila, Jesús; Gasset, María (Public Library of Science (PLoS), 2011)
    Background: The capacity of a polypeptide chain to engage in an amyloid formation process and cause a conformational disease is contained in its sequence. Some of the sequences undergoing fibrillation contain critical ...
  • Solanas, Concepción; Torre, Beatriz G. de la; Fernández Reyes, María; Santiveri, Clara M.; Jiménez, M. Ángeles; Rivas, Luis; Jiménez, Ana I.; Andreu Martínez, David; Cativiela, Carlos (American Chemical Society (ACS), 2010)
    A series of gramicidin S (GS) analogues have been synthesized where the Phe (i + 1) and Pro (i + 2) residues of the beta-turn have been swapped while the respective chiralities (D-, L-) at each position are preserved, and ...
  • Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
  • Pinto, Sandra N.; Dias, Susana A.; Cruz, Ana F.; Mil-Homens, Dalila; Fernandes, Fabio; Valle, Javier; Andreu Martínez, David; Prieto, Manuel; Castanho, Miguel A.R.B.; Coutinho, Ana; Salomé Veiga, Ana (Oxford University Press, 2019)
    Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, ...
  • Solanas, Concepción; Torre, Beatriz G. de la; Fernández Reyes, María; Santiveri, Clara M.; Jiménez, M. Ángeles; Rivas, Luis; Jiménez, Ana I.; Andreu Martínez, David; Cativiela, Carlos (American Chemical Society (ACS), 2009)
    Analogues of the cationic antimicrobial peptide gramicidin S (GS), cyclo(Val-Orn-Leu-D-Phe-Pro)2, with d-Phe residues replaced by different (restricted mobility, mostly) surrogates have been synthesized and used in SAR ...