Browsing by Author "Albà Soler, Mar"

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  • Ruiz Orera, Jorge, 1988-; Messeguer, Xavier; Subirana, Juan A.; Albà Soler, Mar (eLife, 2014)
    Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs ...
  • Radó i Trilla, Núria, 1985- (Universitat Pompeu Fabra, 2013-05-03)
    In this thesis we aimed to study evolutionary implications of low-complexity regions, protein sequences of very simple amino acid composition. Its uncontrolled expansion causes several human diseases, including ...
  • Toll i Riera, Macarena, 1984- (Universitat Pompeu Fabra, 2012-03-28)
    Actualment, degut a la disponibilitat d’un gran nombre de genomes seqüenciats, el camp de la genòmica comparativa està experimentant grans avenços. Ara són possibles una àmplia gama d’estudis que fins fa poc eren inimaginables. ...
  • Mularoni, Loris; Guigó Serra, Roderic; Albà Soler, Mar (BioMed Central, 2006)
    Background: Amino acid tandem repeats are found in nearly one-fifth of human proteins. Abnormal expansion of these regions is associated with several human disorders. To gain further insight into the mutational mechanisms ...
  • Laurie, Steven, 1973- (Universitat Pompeu Fabra, 2013-07-25)
    This thesis comprises comparative genomics analyses primarily focussing on the evolution of mammalian proteins. We concentrate on three species of direct relevance as model organisms, for which high quality genome sequences ...
  • Villanueva Cañas, José Luis, 1984-; Ruiz Orera, Jorge, 1988-; Agea, M. Isabel; Gallo, Maria; Andreu Martínez, David; Albà Soler, Mar (Oxford University Press, 2017)
    The birth of genes that encode new protein sequences is a major source of evolutionary innovation. However, we still understand relatively little about how these genes come into being and which functions they are selected ...
  • Domazet-Lošo, Tomislav; Carvunis, Anne-Ruxandra; Albà Soler, Mar; Šestak, Martin Sebastijan; Bakarić, Robert; Neme, Rafik; Tautz, Diethard (Oxford University Press, 2017)
    Phylostratigraphy is a computational framework for dating the emergence of DNA and protein sequences in a phylogeny. It has been extensively applied to make inferences on patterns of genome evolution, including patterns ...
  • Albà Soler, Mar; Castresana Ruiz-Carrillo, José Ignacio (BioMed Central, 2007)
    Background: It has been shown in a variety of organisms, including mammals, that genes that appeared recently in evolution, for example orphan genes, evolve faster than older genes. Low functional constraints at the time ...
  • Ruiz Orera, Jorge, 1988-; Hernández Rodríguez, Jéssica, 1983-; Chiva, Cristina; Sabidó Aguadé, Eduard, 1981-; Kondova, Ivanela; Bontrop, Ronald E.; Marquès i Bonet, Tomàs, 1975-; Albà Soler, Mar (Public Library of Science, 2015)
    The birth of new genes is an important motor of evolutionary innovation. Whereas many new genes arise by gene duplication, others originate at genomic regions that did not contain any genes or gene copies. Some of these ...
  • Bellora Pereyra, Nicolás; Farré, Domènec; Albà Soler, Mar (BioMed Central, 2007)
    Background: The arrangement of regulatory motifs in gene promoters, or promoter/narchitecture, is the result of mutation and selection processes that have operated over many/nmillions of years. In mammals, tissue-specific ...
  • Blevins, William R.; Carey, Lucas; Albà Soler, Mar (BioMed Central, 2019)
    Objective: The objective of this experiment was to identify transcripts in baker’s yeast (Saccharomyces cerevisiae) that could have originated from previously non-coding genomic regions, or de novo. We generated this data ...
  • Ruiz-Orera, Jorge; Verdaguer-Grau, Pol; Villanueva Cañas, José Luis, 1984-; Messeguer, Xavier; Albà Soler, Mar (Springer, 2018)
    Accumulating evidence indicates that some protein-coding genes have originated de novo from previously non-coding genomic sequences. However, the processes underlying de novo gene birth are still enigmatic. In particular, ...
  • Gayà Vidal, Magdalena; Albà Soler, Mar (BioMed Central, 2014)
    Background: The recent increase in human polymorphism data, together with the availability of genome sequences from several primate species, provides an unprecedented opportunity to investigate how natural selection has ...
  • Ruiz Orera, Jorge,1988- (Universitat Pompeu Fabra, 2017-01-19)
    Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de gens de novo en humans ...
  • Albà Soler, Mar (BioMed Central, 2017)