Browsing by Author "ALFA Study"

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  • Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
    Vilor Tejedor, Natàlia, 1988-; Operto, Grégory; Evans, Tavia E.; Falcón, Carles; Crous-Bou, Marta; Minguillón, Carolina; Cacciaglia, Raffaele; Milà Alomà, Marta; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Garrido Martín, Diego, 1992-; Morán, Sebastián; Esteller, Manel; Adams, Hieab H.; Molinuevo, José Luis; Guigó Serra, Roderic; Gispert López, Juan Domingo; ALFA Study (Springer, 2020)
    Background: Current evidence supports the involvement of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism, and the ε4 allele of APOE gene in hippocampal-dependent functions. Previous studies on the association ...
  • Enhancing the sensitivity of memory tests: reference data for the free and cued selective reminding test and the logical memory task from cognitively healthy subjects with normal alzheimer's disease cerebrospinal fluid biomarker levels
    Brugulat Serrat, Anna, 1986-; Cañas-Martínez, Alba; Canals-Gispert, Lidia; Marne, Paula; Gramunt Fombuena, Nina; Suárez-Calvet, Marc; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Zetterberg, Henrik; Blennow, Kaj; Gispert López, Juan Domingo; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; ALFA Study (IOS Press, 2021)
    Background: Cognitive performance of a given individual should be interpreted in the context of reference standards obtained in cognitively healthy populations. Recent evidence has shown that removing asymptomatic individuals ...
  • Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
    Cacciaglia, Raffaele; Molinuevo, José Luis; Sánchez Benavides, Gonzalo; Falcón, Carles; Gramunt Fombuena, Nina; Brugulat Serrat, Anna, 1986-; Grau-Rivera, Oriol; Gispert López, Juan Domingo; ALFA Study (Wiley, 2018)
    The neuroanatomical bases of episodic memory (EM) and executive functions (EFs) have been widely addressed in patients with brain damage and in individuals with neurologic disorders. These studies reported that larger brain ...
  • Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Genius, Patricia; Rodríguez-Fernández, Blanca; Minguillón, Carolina; Sadeghi, Iman; González Escalante, Armand; Crous-Bou, Marta; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Brugulat Serrat, Anna, 1986-; Sánchez Benavides, Gonzalo; Esteller, Manel; Fauria, Karine; Molinuevo, José Luis; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Wiley, 2024)
    Introduction: In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive ...
  • Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
    Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Minguillón, Carolina; Castro de Moura, Manuel; Piñeyro, David; Esteller, Manel; Molinuevo, José Luis; Guigó Serra, Roderic; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; ALFA Study (MDPI, 2021)
    This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and ...
  • Genetically predicted telomere length and Alzheimer's disease endophenotypes: a Mendelian randomization study
    Rodríguez-Fernández, Blanca; Vilor Tejedor, Natàlia, 1988-; Arenaza Urquijo, Eider M.; Sánchez Benavides, Gonzalo; Suárez-Calvet, Marc; Operto, Grégory; Minguillón, Carolina; Navarro i Cuartiellas, Arcadi, 1969-; Gispert López, Juan Domingo; Sala Vila, Aleix; ALFA Study (BioMed Central, 2022)
    Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes ...
  • Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
    Cacciaglia, Raffaele; Operto, Grégory; Falcón, Carles; González de Echávarri, José Maria; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Milà Alomà, Marta; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (Oxford University Press, 2022)
    The investigation of resting-state functional connectivity (rsFC) in asymptomatic individuals at genetic risk for Alzheimer's disease (AD) enables discovering the earliest brain alterations in preclinical stages of the ...
  • Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer's dementia
    Crous-Bou, Marta; Gascon Merlos, Mireia, 1984-; Gispert López, Juan Domingo; Cirach, Marta; Sánchez Benavides, Gonzalo; Falcón, Carles; Arenaza Urquijo, Eider M.; Gotsens, Xavier; Fauria, Karine; Sunyer Deu, Jordi; Nieuwenhuijsen, Mark J.; Molinuevo, José Luis; ALFA Study (Elsevier, 2020)
    Background: Air quality might contribute to incidence of dementia-related disorders, including Alzheimer’s dementia (AD). The aim of our study is to evaluate the effect of urban environmental exposures (including exposure ...
  • Lifetime stressful events associated with Alzheimer's Pathologies, neuroinflammation and brain structure in a risk enriched cohort
    Palpatzis, Eleni; Akinci, Muge; Aguilar Dominguez, Pablo; Garcia Prat, Marina; Blennow, Kaj; Zetterberg, Henrik; Carboni, Margherita; Kollmorgen, Gwendlyn; Wild, Norbert; Fauria, Karine; Falcón, Carles; Gispert López, Juan Domingo; Suárez-Calvet, Marc; Grau-Rivera, Oriol; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; ALFA Study (Wiley, 2024)
    Objective: Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the ...
  • Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals
    Martí Juan, Gerard; Sanromà, Gerard; Cacciaglia, Raffaele; Falcón, Carles; Operto, Grégory; Molinuevo, José Luis; González Ballester, Miguel Ángel, 1973-; Domingo Gispert, Juan; Piella Fenoy, Gemma; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Wiley, 2020)
    The ε4 allele of the gene Apolipoprotein E is the major genetic risk factor for Alzheimer's Disease. APOE ε4 has been associated with changes in brain structure in cognitively impaired and unimpaired subjects, including ...
  • Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ pathology are detected
    Suárez-Calvet, Marc; Milà Alomà, Marta; Gispert López, Juan Domingo; Salvadó, Gemma; Minguillón, Carolina; Shekari, Mahnaz; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; Sala Vila, Aleix; González de Echávarri, José Maria; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease evolution. The main aim of our study was ...
  • Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
    Brugulat Serrat, Anna, 1986-; Salvadó, Gemma; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Sánchez Benavides, Gonzalo; Gramunt Fombuena, Nina; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (Springer, 2019)
    White matter hyperintensities (WMH) are commonly detected in the brain of elderly individuals and have been associated with a negative impact on multiple cognitive domains. We aim to investigate the impact of global and ...
  • Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer's continuum
    Vilor Tejedor, Natàlia, 1988-; Ciampa, Iacopo; Operto, Grégory; Falcón, Carles; Suárez-Calvet, Marc; Crous-Bou, Marta; Shekari, Mahnaz; Arenaza Urquijo, Eider M.; Milà Alomà, Marta; Grau-Rivera, Oriol; Minguillón, Carolina; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Guigó Serra, Roderic; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2021)
    Background: Perivascular spaces (PVS) have an important role in the elimination of metabolic waste from the brain. It has been hypothesized that the enlargement of PVS (ePVS) could be affected by pathophysiological mechanisms ...
  • Prepandemic alzheimer disease biomarkers and anxious-depressive symptoms during the COVID-19 confinement in cognitively unimpaired adults
    Akinci, Muge; Peña-Gómez, Cleofé; Operto, Grégory; Fuentes-Julian, Sherezade; Deulofeu, Carme; Sánchez Benavides, Gonzalo; Milà Alomà, Marta; Grau-Rivera, Oriol; Gramunt Fombuena, Nina; Navarro i Cuartiellas, Arcadi, 1969-; Minguillón, Carolina; Fauria, Karine; Suridjan, Ivonne; Kollmorgen, Gwendlyn; Bayfield, Anna; Blennow, Kaj; Zetterberg, Henrik; Molinuevo, José Luis; Suárez-Calvet, Marc; Gispert López, Juan Domingo; Arenaza Urquijo, Eider M.; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: Increased anxious-depressive symptomatology is observed in the preclinical stage of Alzheimer disease (AD), which may accelerate disease progression. We investigated whether β-amyloid, cortical ...
  • Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
    Sánchez Benavides, Gonzalo; Salvadó, Gemma; Arenaza Urquijo, Eider M.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Milà Alomà, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Crous-Bou, Marta; Niñerola-Baizán, Aida; Perissinotti, Andrés; Gispert López, Juan Domingo; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: Amyloid beta (Aβ) pathology is an Alzheimer's disease early hallmark. Here we assess the value of longitudinal self- and informant reports of cognitive decline to predict Aβ positron emission tomography (PET) ...
  • Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer's continuum
    Salvadó, Gemma; Milà Alomà, Marta; Shekari, Mahnaz; Operto, Grégory; Falcón, Carles; Cacciaglia, Raffaele; Minguillón, Carolina; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Gispert López, Juan Domingo; ALFA Study (SpringerOpen, 2022)
    Purpose: glial activation is one of the earliest mechanisms to be altered in Alzheimer's disease (AD). Glial fibrillary acidic protein (GFAP) relates to reactive astrogliosis and can be measured in both cerebrospinal fluid ...
  • Sex/gender effects of glial reactivity on preclinical Alzheimer's disease pathology
    Vila-Castelar, Clara; Akinci, Muge; Palpatzis, Eleni; Aguilar Dominguez, Pablo; Operto, Grégory; Kollmorgen, Gwendlyn; Quijano Rubio, Clara; Blennow, Kaj; Zetterberg, Henrik; Falcón, Carles; Fauria, Karine; Gispert López, Juan Domingo; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Arenaza Urquijo, Eider M.; ALFA Study (Nature Research, 2024)
    Glial reactivity may contribute to sex/gender differences in Alzheimer's disease (AD) pathophysiology. Here, we investigated the differential effect of cerebrospinal fluid (CSF) glial markers on AD pathology and neurodegeneration ...
  • Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort
    Salvadó, Gemma; Brugulat Serrat, Anna, 1986-; Sudre, Carole H.; Grau-Rivera, Oriol; Suárez-Calvet, Marc; Falcón, Carles; Fauria, Karine; Cardoso, M. Jorge; Barkhof, Frederik; Molinuevo, José Luis; Gispert López, Juan Domingo; ALFA Study (BioMed Central, 2019)
    Background: White matter hyperintensities (WMH) of presumed vascular origin have been associated with an increased risk of Alzheimer's disease (AD). This study aims to describe the patterns of WMH associated with dementia ...
  • Spatial-temporal patterns of β-amyloid accumulation: a subtype and stage inference model analysis
    Collij, Lyduine E.; Salvadó, Gemma; Wottschel, Viktor; Mastenbroek, Sophie E.; Schoenmakers, Pierre; Heeman, Fiona; Aksman, Leon; Wink, Alle Meije; Berckel, Bart N.M.; van de Flier, Wiesje M.; Scheltens, Philip; Visser, Pieter Jelle; Barkhof, Frederik; Haller, Sven; Gispert López, Juan Domingo; Lopes Alves, Isadora; Alzheimer’s Disease Neuroimaging Initiative; ALFA Study (Lippincott Williams & Wilkins, 2022)
    Background and objectives: β-amyloid (Aβ) staging models assume a single spatial-temporal progression of amyloid accumulation. We assessed evidence for Aβ accumulation subtypes by applying the data-driven Subtype and Stage ...
  • Subjective cognitive decline and anxious/depressive symptoms during the COVID-19 pandemic: what is the role of stress perception, stress resilience, and β-amyloid?
    Akinci, Muge; Sánchez Benavides, Gonzalo; Brugulat Serrat, Anna, 1986-; Peña-Gómez, Cleofé; Palpatzis, Eleni; Shekari, Mahnaz; Deulofeu, Carme; Fuentes-Julian, Sherezade; Salvadó, Gemma; González de Echávarri, José Maria; Suárez-Calvet, Marc; Minguillón, Carolina; Fauria, Karine; Molinuevo, José Luis; Domingo Gispert, Juan; Grau-Rivera, Oriol; Arenaza Urquijo, Eider M.; ALFA Study (BioMed Central, 2022)
    Background: the COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity ...

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