Browsing by Author "Vrijheid, Martine"

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  • A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation
    Monasso, Giulietta S.; Fernández-Barrés, Sílvia; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Vrijheid, Martine; Felix, Janine Frédérique (Taylor & Francis, 2023)
    Circulating vitamin B12 concentrations during pregnancy are associated with offspring health. Foetal DNA methylation changes could underlie these associations. Within the Pregnancy And Childhood Epigenetics Consortium, we ...
  • A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health
    Fernandez-Jimenez, Nora; Vrijheid, Martine; Bustamante Pineda, Mariona; Bilbao, José Ramón (Nature Research, 2022)
    Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ ...
  • A multi-omic analysis of birthweight in newborn cord blood reveals new underlying mechanisms related to cholesterol metabolism
    Alfano, Rossella; Kogevinas, Manolis; Sunyer Deu, Jordi; Vrijheid, Martine; Plusquin, Michelle (Elsevier, 2020)
    Background: Birthweight reflects in utero exposures and later health evolution. Despite existing studies employing high-dimensional molecular measurements, the understanding of underlying mechanisms of birthweight remains ...
  • A systematic comparison of statistical methods to detect interactions in exposome-health associations
    Barrera Gómez, Jose; Agier, Lydiane; Portengen, Lützen; Chadeau-Hyam, Marc; Giorgis-Allemand, Lise; Siroux, Valérie; Robinson, Oliver; Vlaanderen, Jelle; González, Juan Ramón; Nieuwenhuijsen, Mark J.; Vineis, Paolo; Vrijheid, Martine; Vermeulen, Roel; Slama, Rémy; Basagaña Flores, Xavier (BioMed Central, 2017)
    There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human ...
  • Advancing tools for human early lifecourse exposome research and translation (ATHLETE): Project overview
    Vrijheid, Martine; Basagaña Flores, Xavier; Gonzalez, Juan Ramon; Porcel, Joana; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Dadvand, Payam; Fossati, Serena; Guxens Junyent, Mònica; Maitre, Léa; Nieuwenhuijsen, Mark J.; Ortiz, Rodney; Stratakis, Nikos; Sunyer Deu, Jordi; Slama, Rémy (Wolters Kluwer (LWW), 2021)
    Early life stages are vulnerable to environmental hazards and present important windows of opportunity for lifelong disease prevention. This makes early life a relevant starting point for exposome studies. The Advancing ...
  • Air pollution, residential greenness and metabolic dysfunction during early pregnancy in the INfancia y Medio Ambiente (INMA) Cohort
    Rammah, Amal; Whitworth, Kristina W.; Amos, Christopher I.; Estarlich, Marisa; Guxens Junyent, Mònica; Ibarluzea, Jesús; Iñiguez, Carmen; Subiza-Pérez, Mikel; Vrijheid, Martine; Symanski, Elaine (MDPI, 2021)
    Despite extensive study, the role of air pollution in gestational diabetes remains unclear, and there is limited evidence of the beneficial impact of residential greenness on metabolic dysfunction during pregnancy. We used ...
  • Ambient air pollution and overweight and obesity in school-aged children in Barcelona, Spain
    De Bont, Jeroen, 1989-; Casas Sanahuja, Maribel; Barrera Gómez, Jose; Cirach, Marta; Rivas, Ioar; Valvi, Damaskini, 1983-; Álvarez Pedrerol, Mar; Dadvand, Payam; Sunyer Deu, Jordi; Vrijheid, Martine (Elsevier, 2019)
    Background: Ambient air pollution may increase the risk of overweight and obesity in children. However, available evidence is still scarce and has mainly focused on ambient air pollution exposure occurring at home without ...
  • Ambient air pollution and risk of congenital anomalies: a systematic review and meta-analysis
    Vrijheid, Martine; Martinez Murciano, David; Manzanares-Laya, Sandra; Dadvand, Payam; Schembari, Anna, 1982-; Rankin, Judith; Nieuwenhuijsen, Mark J. (National Institute of Environmental Health Sciences (NIEHS), 2011)
    OBJECTIVE: We systematically reviewed epidemiologic studies on ambient air pollution and congenital anomalies and conducted meta-analyses for a number of air pollutant-anomaly combinations. DATA SOURCES AND EXTRACTION: ...
  • Applying the exposome concept in birth cohort research: a review of statistical approaches
    Santos, Susana; Maitre, Léa; Warembourg, Charline; Agier, Lydiane; Richiardi, Lorenzo; Basagaña Flores, Xavier; Vrijheid, Martine (Springer, 2020)
    The exposome represents the totality of life course environmental exposures (including lifestyle and other non-genetic factors), from the prenatal period onwards. This holistic concept of exposure provides a new framework ...
  • Association of exposure to ambient air pollution with thyroid function during pregnancy
    Ghassabian, Akhgar; Pierotti, Livia; Julvez, Jordi; Vrijheid, Martine; Sunyer Deu, Jordi; Guxens Junyent, Mònica (American Medical Association, 2019)
    Importance: Air pollutants interact with estrogen nuclear receptors, but their effect on thyroid signaling is less clear. Thyroid function is of particular importance for pregnant women because of the thyroid’s role in ...
  • Association of fish consumption and mercury exposure during pregnancy with metabolic health and inflammatory biomarkers in children
    Stratakis, Nikos; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; Basagaña Flores, Xavier; Bustamante Pineda, Mariona; Casas Sanahuja, Maribel; Fossati, Serena; González Ruiz, Juan Ramón; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Chatzi, Leda (JAMA Network, 2020)
    IMPORTANCE: The balance of mercury risk and nutritional benefit from fish intake during pregnancy for the metabolic health of offspring to date is unknown. OBJECTIVE: To assess the associations of fish intake and mercury ...
  • Association of lifestyle factors and neuropsychological development of 4-year-old children
    O'Connor, Giselle; Julvez, Jordi; Fernández-Barrés, Sílvia; Navarrete-Muñoz, Eva-María; Murcia, Mario; Tardón, Adonina; Riaño, Isolina; Amiano, Pilar; Ibarluzea, Jesús; García Esteban, Raquel; Vrijheid, Martine; Sunyer Deu, Jordi; Romaguera Bosch, Dora (MDPI, 2020)
    Background: We aimed to assess how lifestyle factors such as diet, sleep, screen viewing, and physical activity, individually, as well as in a combined score, were associated with neuropsychological development in pre-school ...
  • Association of prenatal exposure to endocrine-disrupting chemicals with liver injury in children
    Midya, Vishal; Andrušaitytė, Sandra; Basagaña Flores, Xavier; Casas Sanahuja, Maribel; Fossati, Serena; Gražulevičienė, Regina; Maitre, Léa; Urquiza, José M.; Vrijheid, Martine; Valvi, Damaskini, 1983- (American Medical Association, 2022)
    Importance: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture ...
  • Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts
    Fuertes, Elaine; Sunyer Deu, Jordi; Vrijheid, Martine; Guxens Junyent, Mònica; Kogevinas, Manolis; García Aymerich, Judith; Jacquemin Leonard, Bénédicte (Elsevier, 2020)
    Background: Uncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades. Objective: We ...
  • Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration
    Marques, Irene; Santos, Susana; Monasso, Giulietta S.; Fossati, Serena; Vrijheid, Martine; Nieuwenhuijsen, Mark J.; Jaddoe, Vincent W. V.; Felix, Janine Frédérique (Taylor & Francis, 2023)
    Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health. Epigenetic gestational age acceleration, a discrepancy ...
  • Associations of maternal cell-phone use during pregnancy with pregnancy duration and fetal growth in 4 birth cohorts
    Tsarna, Ermioni; Reedijk, Marije; Birks, Laura Ellen, 1983-; Guxens Junyent, Mònica; Ballester Díez, Ferran; Ha, Mina; Jiménez-Zabala, Ana; Kheifets, Leeka; Lertxundi, Aitana; Lim, Hyungryul; Olsen, Jørn; González-Safont, Llúcia; Sudan, Madhuri; Cardis, Elisabeth; Vrijheid, Martine; Vrijkotte, Tanja; Huss, Anke; Vermeulen, Roel (Oxford University Press, 2019)
    Results from studies evaluating potential effects of prenatal exposure to radio-frequency electromagnetic fields from cell phones on birth outcomes have been inconsistent. Using data on 55,507 pregnant women and their ...
  • Benzophenone-3: Comprehensive review of the toxicological and human evidence with meta-analysis of human biomonitoring studies
    Mustieles, Vicente; Balogh, Ria K.; Axelstad, Marta; Montazeri, Parisa, 1988-; Márquez, Sandra; Vrijheid, Martine; Draskau, Monica K.; Taxvig, Camilla; Peinado, Francisco M.; Berman, Tamar; Frederiksen, Hanne; Fernández, Mariana F.; Vinggaard, Anne Marie; Andersson, Anna-Maria (Elsevier, 2023)
    Background: Benzophenone-3 (BP-3) and its major metabolite benzophenone-1 (BP-1) are widely used as UV filters in sunscreens and cosmetics to prevent sunburn and skin damage, or as stabilizers to prevent photodegradation ...
  • Characterisation of exposure to non-ionising electromagnetic fields in the Spanish INMA birth cohort: study protocol
    Gallastegui, Mara; Guxens Junyent, Mònica; Jiménez-Zabala, Ana; Calvente, Irene; Fernández, Marta; Birks, Laura Ellen, 1983-; Struchen, Benjamin; Vrijheid, Martine; Estarlich, Marisa; Fernandez, Mariana F.; Torrent Quetglas, Maties; Ballester Díez, Ferran; Aurrekoetxea, Juan José; Ibarluzea, Jesús; Guerra, David; González, Julián; Röösli, Martin; Santa Marina, Loreto (BioMed Central, 2016)
    Background: Analysis of the association between exposure to electromagnetic fields of non-ionising radiation (EMF-NIR) and health in children and adolescents is hindered by the limited availability of data, mainly due to ...
  • Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: a panel study
    Fabbri, Lorenzo; Garlantézec, Ronan; Audouze, Karine; Bustamante Pineda, Mariona; Carracedo, Ángel; Chatzi, Leda; González, Juan Ramón; Gražulevičienė, Regina; Keun, Hector C.; Lau, Chung-Ho E.; Sabidó, Eduard; Siskos, Alexandros P.; Slama, Rémy; Thomsen, Cathrine; Wright, John; Yuan, Wen Lun; Casas, Maribel; Vrijheid, Martine; Maitre, Léa (Elsevier, 2023)
    Individuals are exposed to environmental pollutants with endocrine disrupting activity (endocrine disruptors, EDCs) and the early stages of life are particularly susceptible to these exposures. Previous studies have focused ...
  • Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
    Nieuwenhuijsen, Mark J.; Martinez Murciano, David; Grellier, James; Bennett, James; Best, Nicky; Iszatt, Nina; Vrijheid, Martine; Toledano, Mireille B. (National Institute of Environmental Health Sciences (NIEHS), 2009)
    OBJECTIVES: The aim of this study was to review epidemiologic evidence, provide summary risk estimates of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies, and provide ...