Browsing by Author "Sharpe, James"

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  • Dalmasso, Giovanni; Musy, Marco; Niksic, Martina; Robert Moreno, Alexandre; Badía Careaga, Claudio; Sanz-Ezquerro, Juan José; Sharpe, James (Elsevier, 2022)
    Normal organogenesis cannot be recapitulated in vitro for mammalian organs, unlike in species including Drosophila and zebrafish. Available 3D data in the form of ex vivo images only provide discrete snapshots of the ...
  • Marcon, Luciano, 1983-; Arqués, Carlos G.; Torres, Miguel S.; Sharpe, James (Public Library of Science (PLoS), 2011)
    A comprehensive spatio-temporal description of the tissue movements underlying organogenesis would be an extremely useful resource to developmental biology. Clonal analysis and fate mappings are popular experiments to study ...
  • Marcon, Luciano (Universitat Pompeu Fabra, 2015-05-27)
    The specification of the vertebrate limb skeleton is a classical model to study pattern formation during development. Two different theories have been proposed to explain this process: the Turing mechanism and the Positional ...
  • Onimaru, Koh; Kuraku, Shigehiro; Takagi, Wataru; Hyodo, Susumu; Sharpe, James; Tanaka, Mikiko (eLife, 2015)
    The pectoral fins of ancestral fishes had multiple proximal elements connected to their pectoral girdles. During the fin-to-limb transition, anterior proximal elements were lost and only the most posterior one remained as ...
  • Jiménez, Alba; Cotterell, James; Munteanu, Andreea; Sharpe, James (EMBO Press, 2017)
    A major challenge in systems biology is to understand the relationship between a circuit's structure and its function, but how is this relationship affected if the circuit must perform multiple distinct functions within ...
  • Mayer, Jürgen, 1977-; Robert Moreno, Alexandre; Sharpe, James; Swoger, Jim (Nature Research, 2018)
    Light sheet fluorescence microscopy (LSFM) is rapidly becoming an essential technology for mesoscopic imaging of samples such as embryos and adult mouse organs. However, LSFM can suffer from optical artifacts for which ...
  • Lesnicar-Pucko, Gaja (Universitat Pompeu Fabra, 2016-01-28)
    In this work we use a novel in vivo imaging technique and cell behaviour analysis to investigate the cellular basis of limb bud elongation. Recently, it has become clear that oriented cell activities must be involved in ...
  • Jiménez Guri, Eva; Udina, Frederic; Colas, Jean-François; Sharpe, James; Padrón Barthe, Laura; Torres, Miguel S.; Pujades Corbi, Cristina (Public Library of Science (PLoS), 2010)
    Background: Boundaries that prevent cell movement allow groups of cells to maintain their identity and follow independent developmental trajectories without the need for ongoing instructive signals from surrounding tissues. ...
  • Uzkudun, Manu; Marcon, Luciano, 1983-; Sharpe, James (Wiley Blackwell, 2015)
    Parameter optimization coupled with model selection is a convenient approach to infer gene regulatory networks from experimental gene expression data, but so far it has been limited to single cells or static tissues where ...
  • Munteanu, Andreea; Cotterell, James; Solé Vicente, Ricard, 1962-; Sharpe, James (Nature Publishing Group, 2014)
    Interpreting a morphogen gradient into a single stripe of gene-expression is a fundamental unit of patterning in early embryogenesis. From both experimental data and computational studies the feed-forward motifs stand out ...
  • Schulze, Aljoscha, 1980-; Gómez Marín, Alex; Rajendran, Vani G.; Lott, Gus; Musy, Marco; Ahammad, Parvez; Deogade, Ajinkya, 1989-; Sharpe, James; Riedl, Julia, 1981-; Jarriault, David; Trautman, Eric T.; Werner, Christopher; Venkadesan, Madhusudhan; Druckmann, Shaul; Jayaraman, Vivek; Louis, Matthieu (eLife, 2015)
    Behavioral strategies employed for chemotaxis have been described across phyla, but the sensorimotor basis of this phenomenon has seldom been studied in naturalistic contexts. Here, we examine how signals experienced during ...
  • Jiménez, Alba; Cotterell, James; Munteanu, Andreea; Sharpe, James (Cold Spring Harbor Laboratory Press, 2015)
    To what extent does the dynamical mechanism producing a specific biological phenotype bias the ability to evolve into novel phenotypes? We use the interpretation of a morphogen gradient into a single stripe of gene expression ...
  • Cotterell, James; Vila-Cejudo, Marta; Batlle Morera, Laura; Sharpe, James (Company of Biologists, 2020)
    The past decade has seen a renewed appreciation of the central importance of cellular lineages to many questions in biology (especially organogenesis, stem cells and tumor biology). This has been driven in part by a ...
  • Senthivel, Vivek Raj (Universitat Pompeu Fabra, 2018-04-26)
    Engineering self-organised spatial patterns based on reaction-diffusion models can be the stepping stone for tissue engineering. Previous reports based on both theoretical and experimental studies have implied the importance ...
  • Handschuh, Karen; Quintana, Laura; Sharpe, James; Selleri, Licia (Cell Press, 2014)
    Sorting and degradation of receptors and associated signaling molecules maintain homeostasis of conserved signaling pathways during cell specification and tissue development. Yet, whether machineries that sort signaling ...
  • Degenkolbe, Elisa; König, Jana; Zimmer, Julia; Walther, Maria; Reißner, Carsten; Nickel, Joachim; Plöger, Frank; Raspopovic, Jelena, 1984-; Sharpe, James; Dathe, Katarina; Hecht, Jacqueline T.; Mundlos, Stefan; Doelken, Sandra C.; Seemann, Petra (Public Library of Science (PLoS), 2013)
    Growth and Differentiation Factor 5 (GDF5) is a secreted growth factor that belongs to the Bone Morphogenetic Protein (BMP) family and plays a pivotal role during limb development. GDF5 is a susceptibility gene for ...
  • Martínez Abadías, Neus; Mateu-Estivill, Roger; Niksic, Martina; Russo, Lucia; Sharpe, James (Oxford University Press, 2016)
    How the genotype translates into the phenotype through development is critical to fully understand the evolution of phenotypes. We propose a novel approach to directly assess how changes in gene expression patterns are ...
  • Llambrich, Sergi; González-Colom, Rubèn; Wouters, Jens; Roldán, Jorde; Salassa, Sara; Wouters, Kaat; Van Bulck, Vicky; Sharpe, James; Callaerts-Vegh, Zsuzsanna; Vande Velde, Greetje; Martínez Abadías, Neus (MDPI, 2022)
    Altered skeletal development in Down syndrome (DS) results in a brachycephalic skull, flattened face, shorter mandibular ramus, shorter limbs, and reduced bone mineral density (BMD). Our previous study showed that low doses ...
  • Starbuck, John M.; Llambrich, Sergi; González, Rubén; Albaigès-Ràfols, Júlia; Sarlé, Anna; Wouters, Jens; González, Alejandro; Sevillano, Xavier; Sharpe, James; Torre Fornell, Rafael de la; Dierssen, Mara; Velde, Greetje Vande; Martínez Abadías, Neus (Nature Research, 2021)
    Trisomy of human chromosome 21 (Down syndrome, DS) alters development of multiple organ systems, including the face and underlying skeleton. Besides causing stigmata, these facial dysmorphologies can impair vital functions ...
  • Marcon, Luciano, 1983-; Diego, Xavier; Sharpe, James; Müller, Patrick (eLife, 2016)
    The Turing reaction-diffusion model explains how identical cells can self-organize to form spatial patterns. It has been suggested that extracellular signaling molecules with different diffusion coefficients underlie this ...

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