Browsing by Author "Díez Antón, Juana, 1962-"

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  • Jungfleisch, Jennifer, 1986-; Nedialkova, Danny D.; Dotu, Ivan; Sloan, Katherine E.; Martínez Bosch, Neus; Brüning, Lukas; Raineri, Emanuele; Navarro Medrano, Pilar; Bohnsack, Markus T.; Leidel, Sebastian; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2017)
    The impact of RNA structures in coding sequences (CDS) within mRNAs is poorly understood. Here, we identify a novel and highly conserved mechanism of translational control involving RNA structures within coding sequences ...
  • Jungfleisch, Jennifer, 1986-; Böttcher, René; Talló Parra, Marc, 1992-; Pérez Vilaró, Gemma, 1985-; Merits, Andres; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2022)
    Ample evidence indicates that codon usage bias regulates gene expression. How viruses, such as the emerging mosquito-borne Chikungunya virus (CHIKV), express their genomes at high levels despite an enrichment in rare codons ...
  • Puig-Torrents, Mireia; Díez Antón, Juana, 1962- (Frontiers, 2024)
    Arboviruses pose a significant threat to public health globally, demanding innovative approaches for their control. For this, a better understanding of the complex web of interactions established in arbovirus-infected ...
  • Blevins, William Robert, 1987-; Tavella, Teresa; Moro, Simone G.; Blasco Moreno, Bernat, 1986-; Closa-Mosquera, Adrià; Díez Antón, Juana, 1962-; Carey, Lucas, 1980-; Albà Soler, Mar (Nature Research, 2019)
    Cells responds to diverse stimuli by changing the levels of specific effector proteins. These changes are usually examined using high throughput RNA sequencing data (RNA-Seq); transcriptional regulation is generally assumed ...
  • Baquero Pérez, Belinda; Geers, Daryl; Díez Antón, Juana, 1962- (MDPI, 2021)
    There are over 100 different chemical RNA modifications, collectively known as the epitranscriptome. N6-methyladenosine (m6A) is the most commonly found internal RNA modification in cellular mRNAs where it plays important ...
  • Pérez Vilaró, Gemma, 1985-; Fernández-Carrillo, Carlos; Mensa, Laura; Miquel, Rosa; Sanjuan, Xavier; Forns, Xavier; Pérez del Pulgar, Sofía; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Decoding the myriad of interactions that hepatitis C virus (HCV) establishes with infected cells is mandatory to obtain a complete understanding of HCV biology and its associated pathogenesis. We and ...
  • Chen, Tzu-Chun; Talló Parra, Marc, 1992-; Cao, Qian M.; Kadener, Sebastian; Böttcher, René; Pérez Vilaró, Gemma, 1985-; Boonchuen, Pakpoom; Somboonwiwat, Kunlaya; Díez Antón, Juana, 1962-; Sarnow, Peter (Public Library of Science (PLoS), 2020)
    Viruses subvert macromolecular pathways in infected host cells to aid in viral gene amplification or to counteract innate immune responses. Roles for host-encoded, noncoding RNAs, including microRNAs, have been found to ...
  • Martinez, Javier P.; Hinkelmann, Bettina; Fleta Soriano, Eric, 1983-; Steinmetz, Heinrich; Jansen, Rolf; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2013)
    Drug-resistance and therapy failure due to drug-drug interactions are the main challenges in current treatment against Human Immunodeficiency Virus (HIV) infection. As such, there is a continuous need for the development ...
  • Vogel-González, Marina; Talló Parra, Marc, 1992-; Herrera-Fernández, Víctor; Pérez Vilaró, Gemma, 1985-; Chillón, Miguel; Nogués Solan, Francesc Xavier; Gómez-Zorrilla, Silvia; López Montesinos, Inmaculada; Arnau-Barrés, Isabel; Sorli Redó, M. Luisa; Horcajada Gallego, Juan Pablo; García-Giralt, Natalia; Pascual Santos, Julio; Díez Antón, Juana, 1962-; Vicente García, Rubén, 1978-; Güerri Fernández, Roberto (MDPI, 2021)
    Background: Zinc is an essential micronutrient that impacts host-pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc ...
  • Galão, Rui Pedro Ribeiro; Chari, Ashwin; Alves-Rodrigues, Isabel; Lobão, Daniela; Mas, Antonio; Kambach, Christian; Fischer, Utz; Díez Antón, Juana, 1962- (Cold Spring Harbor Laboratory Press (CSHL Press), 2010)
    LSm1-7 complexes promote cellular mRNA degradation, in addition to translation and replication of positive-strand RNA viruses such as the Brome mosaic virus (BMV). Yet, how LSm1-7 complexes act on their targets remains ...
  • Suñer, Clara; Sibilio, Annarita; Martín, Judit; Castellazzi, Chiara Lara; Reina García, Óscar, 1976-; Dotu, Ivan; Caballé, Adrià; Rivas, Elisa; Calderone, Vittorio; Díez Antón, Juana, 1962-; Nebreda, Ángel R.; Méndez de la Iglesia, Raúl (eLife, 2022)
    Chronic inflammation is a major cause of disease. Inflammation resolution is in part directed by the differential stability of mRNAs encoding pro-inflammatory and anti-inflammatory factors. In particular, tristetraprolin ...
  • Huffman, Tori; Link, Kathryn; Nardini, John; Poag, Laura; Flores, Kevin; Banks, H. Thomas; Blasco Moreno, Bernat, 1986-; Jungfleisch, Jennifer, 1986-; Díez Antón, Juana, 1962- (Academic Publications, 2014)
    Positive-strand RNA viruses, such as the brome mosaic virus (BMV) and hepatitis C virus, utilize a replication cycle which involves the recruitment of RNA genomes from the cellular translation machinery to the viral ...
  • Schneider, Konstantin; Krömer, Jens Olaf; Wittmann, Christoph; Alves-Rodrigues, Isabel; Meyerhans, Andreas; Díez Antón, Juana, 1962-; Heinzle, Elmar (BioMed Central, 2009)
    Background The cellular proteins Pat1p, Lsm1p, and Dhh1p are required for the replication of some positive-strand viruses and therefore are potential targets for new antiviral drugs. To prioritize host targets for antiviral ...
  • Fleta Soriano, Eric, 1983-; Martinez, Javier P.; Hinkelmann, Bettina; Gerth, Klaus; Washausen, Peter; Díez Antón, Juana, 1962-; Frank, Ronald; Sasse, Florenz; Meyerhans, Andreas (BioMed Central, 2014)
    Background: The nuclear export of unspliced and partially spliced HIV-1 mRNA is mediated by the recognition of a leucine-rich nuclear export signal (NES) in the HIV Rev protein by the host protein CRM1/Exportin1. This makes ...
  • Baquero Pérez, Belinda; Yonchev, Ivaylo D.; Delgado-Tejedor, Anna; Medina, Rebeca; Puig-Torrents, Mireia; Sudbery, Ian; Begik, Oguzhan; Wilson, Stuart A.; Novoa, Eva Maria; Díez Antón, Juana, 1962- (Nature Research, 2024)
    Despite the nuclear localization of the m6A machinery, the genomes of multiple exclusively-cytoplasmic RNA viruses, such as chikungunya (CHIKV) and dengue (DENV), are reported to be extensively m6A-modified. However, these ...
  • Koutsoudakis, George; Paris de León, Alexia; Herrera, Carolina; Dorner, Marcus; Pérez Vilaró, Gemma, 1985-; Lyonnais, Sébastien; Grijalvo, Santiago; Eritja, Ramon; Meyerhans, Andreas; Mirambeau, Gilles; Díez Antón, Juana, 1962- (American Society for Microbiology, 2017)
    A hepatitis C virus (HCV) epidemic affecting HIV-infected men who have sex with men (MSM) is expanding worldwide. In spite of the improved cure rates obtained with the new direct-acting antiviral drug (DAA) combinations, ...
  • Elsebai, Mahmoud Fahmi; Koutsoudakis, George; Saludes, Verónica; Pérez Vilaró, Gemma, 1985-; Turpeinen, Ari; Mattila, Sampo; Pirttilä, Anna Maria; Fontaine, Fabien; Mehiri, Mohamed; Meyerhans, Andreas; Díez Antón, Juana, 1962- (American Society for Microbiology, 2016)
    Hepatitis C virus (HCV) infection is the leading cause of chronic liver diseases. Water extracts of the leaves of the wild Egyptian artichoke (WEA) [Cynara cardunculus L. var. sylvestris (Lam.) Fiori] have been used for ...
  • Llorens, Franc; Thüne, Katrin; Martí Puig, Eulàlia; Kanata, Eirini; Dafou, Dimitra; Díaz Lucena, Daniela; Vivancos Prellezo, Ana; Shomroni, Orr; Zafar, Saima; Schmitz, Matthias; Michel, Uwe; Fernández Borges, Natalia; Andreóletti, Olivier; del Río, José Antonio; Díez Antón, Juana, 1962-; Fischer, André; Bonn, Stefan; Sklaviadis, Theodoros K.; Torres, Juan María; Ferrer, Isidre; Zerr, Inga (Public Library of Science (PLoS), 2018)
    Increasing evidence indicates that microRNAs (miRNAs) are contributing factors to neurodegeneration. Alterations in miRNA signatures have been reported in several neurodegenerative dementias, but data in prion diseases are ...
  • Kobayashi-Ishihara, Mie; Smutná, Katarína, 1991-; Alonso, Florencia E.; Argilaguet Marqués, Jordi, 1977-; Esteve-Codina, Anna; Geiger, Kerstin; Rogenmoser, Selina; Oliva Miguel, Baldomero; Martinez, Javier P.; Díez Antón, Juana, 1962-; Meyerhans, Andreas (Nature Research, 2023)
    Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe the Schlafen 12 ...
  • Koutsoudakis, George; Romero-Brey, Inés; Berger, Carola; Pérez Vilaró, Gemma, 1985-; Monteiro Perin, Paula; Vondran, Florian Wolfgang Rudolf; Kalesse, Markus; Harmrolfs, Kirsten; Müller, Rolf; Martínez, Javier P.; Pietschmann, Thomas; Bartenschlager, Ralf; Brönstrup, Mark; Meyerhans, Andreas; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Soraphen A (SorA) is a myxobacterial metabolite that inhibits the acetyl-CoA carboxylase, a key enzyme in lipid biosynthesis. We have previously identified SorA to efficiently inhibit the human ...

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