Browsing by Author "Covas Planells, Maria Isabel"

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  • A functional virgin olive oil enriched with olive oil and thyme phenolic compounds improves the expression of cholesterol efflux-related genes: a randomized, crossover, controlled trial
    Farràs Mañé, Marta; Arranz, Sara; Carrión, Sílvia; Subirana Cachinero, Isaac; Muñoz-Aguayo, D.; Blanchart, Gemma; Kool, Marjon; Solà, Rosa; Motilva, Maria-José; Escolà-Gil, Joan Carles; Rubió, Laura; Fernández-Castillejo, Sara; Pedret, Anna; Estruch, Ramón; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Hernáez, Álvaro; Castañer, Olga (MDPI, 2019)
    The consumption of antioxidant-rich foods such as virgin olive oil (VOO) promotes high-density lipoprotein (HDL) anti-atherogenic capacities. Intake of functional VOOs (enriched with olive/thyme phenolic compounds (PCs)) ...
  • Alkylglycerols reduce serum complement and plasma vascular endothelial growth factor in obese individuals
    Parri, Alejandra; Fitó Colomer, Montserrat; Torres, C. F.; Muñoz-Aguayo, D.; Schröder, Helmut, 1958-; Cano, J. F.; Vázquez, Luis Alberto; Reglero, G.; Covas Planells, Maria Isabel (Elsevier, 2016)
    Alkylglycerols (AKGs), isolated or present in shark liver oil have anti-inflammatory properties. Complement 3 (C3) and 4 (C4) participate in lipid metabolism and in obesity, contributing to the metabolic syndrome and to ...
  • Analysis of free hydroxytyrosol in human plasma following the administration of olive oil.
    Pastor, Antonio; Rodríguez-Morató, Jose, 1987-; Olesti Muñoz, Eulàlia, 1991-; Pujadas Bastardes, Mitona; Pérez Mañá, Clara; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Solà, Rosa; Motilva, Maria-José; Farré Albaladejo, Magí; Torre Fornell, Rafael de la (Elsevier, 2016)
    Hydroxytyrosol (HT) from olive oil, a potent bioactive molecule with health benefits, has a poor bioavailability, its free form (free HT) being undetectable so far. This fact leads to the controversy whether attained HT ...
  • Cardioprotective effect of a virgin olive oil enriched with bioactive compounds in spontaneously hypertensive rats
    Vázquez, Alejandra; Sánchez-Rodriguez, Estefanía; Vargas, Félix; Montoro-Molina, Sebastián; Romero-Cuevas, Miguel; Espejo, Juan-Antonio; Vilchez, Pedro; Jaramillo, Sara; Olmo-García, Lucía; Carrasco-Pancorbo, Alegría; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Martínez de Victoria, Emilio; Mesa, Maria-Dolores (MDPI, 2019)
    Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), ...
  • Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans: a randomized, controlled trial
    Boronat Rigol, Anna, 1990-; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz Aguayo, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)
    Introduction: The simple phenol hydroxytyrosol (OHTyr) has been associated with the beneficial health effects of extra virgin olive oil. Pre-clinical studies have identified Tyr hydroxylation, mediated by cytochrome P450 ...
  • Characterization of human gene expression changes after olive oil ingestion: an exploratory approach
    Konstantinidou, Valentini; Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Torre Fornell, Rafael de la; Anglada Busquets, Roger; Dopazo, Ana; Covas Planells, Maria Isabel (Univerzita Karlova v Praze, Fakulta Socialnich Ved, 2009)
    Olive oil consumption is protective against risk factors for cardiovascular and cancer diseases. A nutrigenomic approach was performed to assess whether changes in gene expression could occur in human peripheral blood ...
  • Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans
    Boronat Rigol, Anna, 1990-; Mateus Rodriguez, Julian Andrés; Soldevila-Domenech, Natalia; Guerra Albà, Mercè; Rodríguez-Morató, Jose, 1987-; Varon, Carlota; Muñoz, Daniel; Barbosa, Francina; Morales, Juan Carlos; Gaedigk, Andreas; Langohr, Klaus; Covas Planells, Maria Isabel; Pérez Mañá, Clara; Fitó Colomer, Montserrat; Tyndale, Rachel F.; Torre Fornell, Rafael de la (Elsevier, 2019)
    Here we present new and original data on the endogenous conversion of tyrosol (Tyr) into hydroxytyrosol (OHTyr) in humans and its effects on the cardiovascular system. A randomized, crossover, controlled clinical trial was ...
  • Dietary total antioxidant capacity and mortality in the PREDIMED study.
    Henríquez-Sánchez, P.; Sánchez-Villegas, A.; Ruano-Rodríguez, C.; Gea, Alfredo; Lamuela-Raventós, Rosa M.; Estruch, Ramón; Salas-Salvadó, Jordi; Covas Planells, Maria Isabel; Corella, Dolores; Schröder, Helmut, 1958-; Gutierrez-Bedmar, Mario; Santos-Lozano, José; Pinto, Xavier; Arós, Fernando; Fiol, Miquel; Tresserra-Rimbau, Anna; Ros, Emilio; Martínez-González, Miguel Ángel, 1957-; Serra-Majem, Luis; PREDIMED investigators (Springer, 2016)
    PURPOSE: The aim of the present study was to assess the association between the dietary total antioxidant capacity, the dietary intake of different antioxidants and mortality in a Mediterranean population at high cardiovascular ...
  • Effects of virgin olive oils differing in their bioactive compound contents on biomarkers of oxidative stress and inflammation in healthy adults: a randomized double-blind controlled trial
    Sánchez-Rodriguez, Estefanía; Biel-Glesson, Sara; Fernández-Navarro, Jose-Ramón; Calleja, Miguel Angel; Espejo-Calvo, Juan A.; Gil-Extremera, Blas; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Vilchez, Pedro; Alche, Juan de Dios; Martínez de Victoria, Emilio; Gil, Angel; Mesa, Maria-Dolores (MDPI, 2019)
    A regular consumption of virgin olive oil (VOO) is associated with a reduced risk of cardiovascular disease. We aimed to assess whether the raw intake of an optimized VOO (OVOO, 490 ppm of phenolic compounds and 86 ppm of ...
  • Effects of virgin olive oils differing in their bioactive compound contents on metabolic syndrome and endothelial functional risk biomarkers in healthy adults: a randomized double-blind controlled trial
    Sánchez-Rodriguez, Estefanía; Lima-Cabello, Elena; Biel-Glesson, Sara; Fernández-Navarro, Jose-Ramón; Calleja, Miguel Angel; Roca Bigorra, Maria; Espejo-Calvo, Juan A.; Gil-Extremera, Blas; Soria-Florido, Maria; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Alche, Juan de Dios; Martínez de Victoria, Emilio; Gil, Angel; Mesa, Maria-Dolores (MDPI, 2018)
    The aim of this study was to evaluate the effect of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes on metabolic syndrome and endothelial function biomarkers in healthy adults. The trial was a ...
  • From green technology to functional olive oils: assessing the best combination of olive tree-related extracts with complementary bioactivities
    Hernáez, Álvaro; Jaramillo, Sara; García Borrego, Aránzazu; Espejo-Calvo, Juan A.; Covas Planells, Maria Isabel; Blanchart, Gemma; Torre Fornell, Rafael de la; Carrasco-Pancorbo, Alegría; Mesa, Maria-Dolores; Fernández Prior, Maria África; Castañer, Olga; Fitó Colomer, Montserrat (MDPI, 2021)
    Our aim was to assess the combination of olive tree-related extracts with the most favorable profile of in vitro bioactive properties. We tested the antioxidant (increment of low-density lipoprotein resistance against ...
  • Impact of phenol-enriched olive oils on serum metabonome and its relationship with cardiometabolic parameters. a randomized, double-blind, cross-over, controlled trial
    Farràs Mañé, Marta; Swann, Jonathan Richard; Rowland, Ian; Rubió, Laura; Subirana Cachinero, Isaac; Catalán, Úrsula; Motilva, Maria-José; Solà, Rosa; Covas Planells, Maria Isabel; Blanco-Vaca, Francisco; Fitó Colomer, Montserrat; Mayneris Perxachs, Jordi (MDPI, 2022)
    Phenol-rich foods consumption such as virgin olive oil (VOO) has been shown to have beneficial effects on cardiovascular diseases. The broader biochemical impact of VOO and phenol-enriched OOs remains, however, unclear. A ...
  • Impact of phenol-enriched virgin olive oils on the postprandial levels of circulating microRNAs related to cardiovascular disease
    Daimiel, Lidia; Micó, Víctor; Valls, Rosa M.; Pedret, Anna; Motilva, Maria-José; Rubió, Laura; Fitó Colomer, Montserrat; Farràs Mañé, Marta; Covas Planells, Maria Isabel; Solá, Rosa; Ordovás, José M. (Wiley-VCH Verlag, 2020)
    Scope: We investigate the postprandial modulation of cardiovascular-related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols. Methods and results: It is randomized, ...
  • Impact of virgin olive oil and phenol-enriched virgin olive oils on the HDL Proteome in hypercholesterolemic subjects: a double blind, randomized, controlled, cross-over clinical trial (VOHF Study).
    Pedret, Anna; Catalán, Úrsula; Fernández-Castillejo, Sara; Farràs Mañé, Marta; Valls, Rosa M.; Rubió, Laura; Canela, Núria; Aragonés, Gerard; Romeu, Marta; Castañer, Olga; Torre Fornell, Rafael de la; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Motilva, Maria-José; Solà, Rosa (Public Library of Science, 2015)
    The effects of olive oil phenolic compounds (PCs) on HDL proteome, with respect to new aspects of cardioprotective properties, are still unknown. The aim of this study was to assess the impact on the HDL protein cargo of ...
  • Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation
    Pérez Martínez, Pablo; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat; Schröder, Helmut, 1958-; Torre Fornell, Rafael de la; López Miranda, José (Oxford University Press, 2017)
    The importance of metabolic syndrome (MetS) lies in its associated risk of cardiovascular disease and type 2 diabetes, as well as other harmful conditions such as nonalcoholic fatty liver disease. In this report, the ...
  • May bioactive compounds from the olive fruit improve the postprandial insulin response in healthy adults?
    Sánchez-Rodriguez, Estefanía; Vázquez Aguilar, Laura Alejandra; Biel-Glesson, Sara; Fernández-Navarro, Jose-Ramón; Espejo-Calvo, Juan A.; Olmo Peinado, Jose Maria; Torre Fornell, Rafael de la; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Romero, Concepción; Brenes, Manuel; Martínez de Victoria, Emilio; Gil, Angel; Mesa, Maria-Dolores (Elsevier, 2021)
    Scope. The postprandial effects of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes from the olive fruit on plasma glucose and insulin (primary outcomes), and gastrointestinal hormones responses ...
  • Molecular mechanisms involved in the protective effect of Mediterranean diet and olive oil consumption in humans
    Konstantinidou, Valentini (Universitat Pompeu Fabra, 2011-04-12)
    The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be ...
  • Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study
    Khymenets, Olha, 1974-; Fitó Colomer, Montserrat; Covas Planells, Maria Isabel; Farré Albaladejo, Magí; Pujadas, María Antonia; Muñoz Aguayo, Daniel; Konstantinidou, Valentini; Torre Fornell, Rafael de la (Mary Ann Liebert, Inc, 2009)
    Virgin olive oil (VOO) is considered to be one of the main components responsible for the health benefits of the Mediterranean diet, particularly against atherosclerosis where peripheral blood mononuclear cells (PBMNCs) ...
  • Olive oil polyphenols decrease LDL concentrations and LDL atherogenicity in men in a randomized controlled trial.
    Hernáez, Álvaro; Remaley, Alan T.; Farràs Mañé, Marta; Fernández-Castillejo, Sara; Subirana Cachinero, Isaac; Schröder, Helmut, 1958-; Fernández-Mampel, Mireia; Muñoz Aguayo, Daniel; Sampson, Maureen; Solà, Rosa; Farré Albaladejo, Magí; Torre Fornell, Rafael de la; López Sabater, M. Carmen; Nyyssönen, Kristiina; Zunft, Hans-Joachim F.; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat (American Society for Nutrition, 2015)
    BACKGROUND: Olive oil polyphenols have shown protective effects on cardiovascular risk factors. Their consumption decreased oxidative stress biomarkers and improved some features of the lipid profile. However, their effects ...
  • Olive oil polyphenols enhance high-density lipoprotein function in humans: a randomized controlled trial
    Hernáez, Álvaro; Fernández-Castillejo, Sara; Farràs Mañé, Marta; Catalán, Úrsula; Subirana Cachinero, Isaac; Montes, Rosa; Solà, Rosa; Muñoz Aguayo, Daniel; Gelabert-Gorgues, Anna; Díaz Gil, Oscar; Nyyssönen, Kristiina; Zunft, Hans-Joachim F.; Torre Fornell, Rafael de la; Martín-Peláez, Sandra; Pedret, Anna; Remaley, Alan T.; Covas Planells, Maria Isabel; Fitó Colomer, Montserrat (American Hearth Association, 2014)
    Objective: Olive oil polyphenols have shown beneficial properties against cardiovascular risk factors. Their consumption has been associated with higher cholesterol content in high-density lipoproteins (HDL). However, data ...

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