Visualitza per autoria "Tartaglia, Gian Gaetano"

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  • Determination of primary microRNA processing in clinical samples by targeted pri-miR-sequencing
    Conrad, Thomas; Ntini, Evgenia; Lang, Benjamin; Cozzuto, Luca; Andersen, Jesper B.; Marquardt, Jens U.; Ponomarenko, Julia; Tartaglia, Gian Gaetano; Vang Ørom, Ulf A. (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    MicroRNA expression is important for gene regulation and deregulated microRNA expression is often observed in diseases such as cancer. The processing of primary microRNA transcripts is an important regulatory step in ...
  • Discovering the 3' UTR-mediated regulation of alpha-synuclein
    Marchese, Domenica, 1986-; Botta Orfila, Teresa; Cirillo, Davide; Rodríguez, Juan Antonio; Livi, Carmen Maria; Fernández-Santiago, Ruben; Ezquerra, Mario; Martí, Maria José; Bechara, Elias; Tartaglia, Gian Gaetano; Catalan multiple system atrophy-registry (CMSAR) (Oxford University Press, 2017)
    Recent evidence indicates a link between Parkinson's Disease (PD) and the expression of a-synuclein (SNCA) isoforms with different 3' untranslated regions (3'UTRs). Yet, the post-transcriptional mechanisms regulating SNCA ...
  • DnaK functions as a central hub in the E. colichaperone network
    Calloni, Giulia; Chen, Taotao; Schermann, Sonya M.; Chang, Hung-chun; Genevaux, Pierre; Agostini, Federico, 1985-; Tartaglia, Gian Gaetano (Elsevier, 2012)
    Cellular chaperone networks prevent potentially toxic protein aggregation and ensure proteome integrity. Here, we used Escherichia coli as a model to understand the organization of these networks, focusing on the cooperation ...
  • DualSeqDB: the host-pathogen dual RNA sequencing database for infection processes
    Macho Rendón, Javier; Lang, Benjamin; Ramos Llorens, Marc; Tartaglia, Gian Gaetano; Torrent Burgas, Marc (Oxford University Press, 2020)
    Despite antibiotic resistance being a matter of growing concern worldwide, the bacterial mechanisms of pathogenesis remain underexplored, restraining our ability to develop new antimicrobials. The rise of high-throughput ...
  • Editorial: Molecular evolution: You learn from your mistakes
    Fantini, Marco; Sarti, Edoardo; Tartaglia, Gian Gaetano; Pastore, Annalisa (Frontiers, 2022)
  • Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells
    Riemschoss, Katrin; Arndt, Verena; Bolognesi, Benedetta; von Eisenhart-Rothe, Philipp; Liu, Shu; Buravlova, Oleksandra; Duernberger, Yvonne; Paulsen, Lydia; Hornberger, Annika; Hossinger, André; Lorenzo Gotor, Maria de las Nieves; Hogl, Sebastian; Müller, Stephan A.; Tartaglia, Gian Gaetano; Lichtenthaler, Stefan F.; Vorberg, Ina M. (Life Science Alliance, 2019)
    Prions of lower eukaryotes are self-templating protein aggregates that replicate by converting homotypic proteins into stable, tightly packed beta-sheet-rich protein assemblies. Propagation is mediated by prion domains, ...
  • FUS phase separation is modulated by a molecular chaperone and methylation of arginine cation-π interactions
    Qamar, Seema; Tartaglia, Gian Gaetano; St George-Hyslop, Peter (Elsevier, 2018)
    Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we ...
  • Homage to Chris Dobson
    Baum, Jean; Chiti, Fabrizio; de Simone, Alfonso; Knowles, Tuomas P.J.; Kumita, Janet R.; Radford, Sheena E.; Robinson, Carol V.; Salvatella, Xavier; Valelli, Karen; Vendruscolo, Michele; Pastore, Annalisa; Tartaglia, Gian Gaetano (Frontiers, 2019)
  • HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade
    Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Armaos, Alexandros, 1989-; Garone, Maria Giovanna; Iberite, Federica; Cipriano, Andrea; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa (Nature Research, 2020)
    Neuronal differentiation is a timely and spatially regulated process, relying on precisely orchestrated gene expression control. The sequential activation/repression of genes driving cell fate specification is achieved by ...
  • Identification of long non-coding RNAs and RNA binding proteins in breast cancer subtypes
    Cava, Claudia; Armaos, Alexandros, 1989-; Lang, Benjamin; Tartaglia, Gian Gaetano; Castiglioni, Isabella (Nature Research, 2022)
    Breast cancer is a heterogeneous disease classified into four main subtypes with different clinical outcomes, such as patient survival, prognosis, and relapse. Current genetic tests for the differential diagnosis of BC ...
  • In silico, in vitro, and in vivo approaches to identify molecular players in fragile X tremor and ataxia syndrome
    Haify, Saif N.; Botta Orfila, Teresa; Hukema, Renate K.; Tartaglia, Gian Gaetano (Frontiers Media, 2020)
    Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset neurodegenerative monogenetic disorder affecting carriers of premutation (PM) forms of the FMR1 gene, resulting in a progressive development of tremors, ...
  • Insights on protein thermal stability: a graph representation of molecular interactions
    Miotto, Mattia; Olimpieri, Pier Paolo; Di Rienzo, Lorenzo; Ambrosetti, Francesco; Corsi, Pietro; Lepore, Rosalba; Tartaglia, Gian Gaetano; Milanetti, Edoardo (Oxford University Press, 2019)
    Motivation: Understanding the molecular mechanisms of thermal stability is a challenge in protein biology. Indeed, knowing the temperature at which proteins are stable has important theoretical implications, which are ...
  • Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex
    Panatta, Emanuele; Lena, Anna Maria; Mancini, Mara; Smirnov, Artem; Marini, Alberto; Delli Ponti, Riccardo, 1987-; Botta Orfila, Teresa; Tartaglia, Gian Gaetano; Mauriello, Alessandro; Zhang, Xinna; Calin, George A.; Melino, Gerry; Candi, Eleonora (EMBO Press, 2020)
    The mechanisms that regulate the switch between epidermal progenitor state and differentiation are not fully understood. Recent findings indicate that the chromatin remodelling BAF complex (Brg1-associated factor complex ...
  • Long non-coding RNA-polycomb intimate rendezvous
    Cerase, Andrea; Tartaglia, Gian Gaetano (Royal Society, 2020)
    The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of ...
  • Machine learning methods applied to genotyping data capture interactions between single nucleotide variants in late onset Alzheimer's disease
    Arnal, Magdalena; Bini, Giorgio; Fernández Orth, Dietmar; Samaras, Eleftherios; Kassis, Maya; Aisopos, Fotis; Rambla de Argila, Jordi; Paliouras, George; Garrard, Peter; Giambartolomei, Claudia; Tartaglia, Gian Gaetano (Wiley Open Access, 2022)
    Introduction: Genome-wide association studies (GWAS) in late onset Alzheimer's disease (LOAD) provide lists of individual genetic determinants. However, GWAS do not capture the synergistic effects among multiple genetic ...
  • Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins
    Lang, Benjamin; Yang, Jae-Seong; Garriga-Canut, Mireia; Speroni, Silvia; Aschern, Moritz; Gili, Maria; Hoffmann, Tobias, 1990-; Tartaglia, Gian Gaetano; Maurer, Sebastian (Oxford University Press, 2021)
    RNA-binding proteins (RBPs) are crucial factors of post-transcriptional gene regulation and their modes of action are intensely investigated. At the center of attention are RNA motifs that guide where RBPs bind. However, ...
  • Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments
    Monti, Michele; Guiducci, Giulia; Paone, Alessio; Rinaldo, Serena; Giardina, Giorgio; Liberati, Francesca Romana; Cutruzzolà, Francesca; Tartaglia, Gian Gaetano (Elsevier, 2021)
    Human serine hydroxymethyltransferase (SHMT) regulates the serine-glycine one carbon metabolism and plays a role in cancer metabolic reprogramming. Two SHMT isozymes are acting in the cell: SHMT1 encoding the cytoplasmic ...
  • Molecular pathophysiology of fragile x-associated tremor/ataxia syndrome and perspectives for drug development
    Botta Orfila, Teresa; Tartaglia, Gian Gaetano; Michalon, Aubin (Springer, 2016)
    Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder manifesting in carriers of 55 to 200 CGG repeats in the 5' untranslated region (UTR) of the fragile X mental retardation gene ...
  • Neurodegeneration and cancer: where the disorder prevails
    Klus, Petr, 1985-; Cirillo, Davide; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Nature Publishing Group, 2015)
    It has been reported that genes up-regulated in cancer are often down-regulated in neurodegenerative disorders and vice versa. The fact that apparently unrelated diseases share functional pathways suggests a link between ...
  • Neurodegenerative diseases: quantitative predictions of protein-RNA interactions
    Cirillo, Davide; Agostini, Federico, 1985-; Klus, Petr, 1985-; Marchese, Domenica, 1986-; Rodríguez, Silvia; Bolognesi, Benedetta; Tartaglia, Gian Gaetano (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Increasing evidence indicates that RNA plays an active role in a number of neurodegenerative diseases. We recently introduced a theoretical framework, catRAPID, to predict the binding ability of protein and RNA molecules. ...

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