Browsing by Author "Muñoz Cánoves, Pura, 1962-"

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  • Perdiguero, Eusebio, 1968-; Sousa-Victor, Pedro; Ruiz Bonilla, Vanesa, 1979-; Jardí, Mercè; Caelles Franch, Carme; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2011)
    Repair of damaged tissue requires the coordinated action of inflammatory and tissue-specific cells to restore homeostasis, but the underlying regulatory mechanisms are poorly understood. In this paper, we report new roles ...
  • Ardite, Esther; Perdiguero, Eusebio, 1968-; Vidal Iglesias, Berta; Gutarra, Susana; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Rockefeller University Press, 2012)
    There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for ...
  • García Forero, Carlos; Sousa-Victor, Pedro; Muñoz Cánoves, Pura, 1962- (Elsevier, 2017)
    Adult stem cells, particularly those resident in tissues with little turnover, are largely quiescent and only activate in response to regenerative demands, while embryonic stem cells continuously replicate, suggesting ...
  • Segalés Dalmau, Jessica; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962- (Frontiers, 2016)
    Formation of skeletal muscle fibers (myogenesis) during development and after tissue injury in the adult constitutes an excellent paradigm to investigate the mechanisms whereby environmental cues control gene expression ...
  • Bengal, Eyal; Perdiguero, Eusebio, 1968-; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (F1000Research, 2017)
    Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the ...
  • Victor, Pedro Sousa (Universitat Pompeu Fabra, 2012-02-27)
    Muscle aging, in particular, is characterized by the reduction of tissue mass and function, which are particularly prominent in geriatric individuals undergoing sarcopenia. The age-associated muscle wasting is also associated ...
  • García-Prat, Laura, 1987- (Universitat Pompeu Fabra, 2015-10-14)
    During aging, muscle stem cell regenerative function declines, being maximal at advanced geriatric age, due to a quiescence-to-senescence transition. How quiescence is maintained over long periods of time remains largely ...
  • Gómez-Del Arco, Pablo; Perdiguero, Eusebio, 1968-; Muñoz Cánoves, Pura, 1962-; Redondo, Juan Miguel (Elsevier, 2016)
    Heart muscle maintains blood circulation, while skeletal muscle powers skeletal movement. Despite having similar myofibrilar sarcomeric structures, these striated muscles differentially express specific sarcomere components ...
  • Vidal Iglesias, Berta (Universitat Pompeu Fabra, 2008-09-17)
    Duchenne muscular dystrophy (DMD) is a fatal degenerative disorder of locomotor and respiratory muscles, in which myofibers are progressively replaced by non-muscular fibrotic tissue. Here, we show that fibrin/ogen accumulates ...
  • Brack, Andrew S.; Muñoz Cánoves, Pura, 1962- (BioMed Central, 2016)
    Skeletal muscle has a remarkable capacity to regenerate by virtue of its resident stem cells (satellite cells). This capacity declines with aging, although whether this is due to extrinsic changes in the environment and/or ...
  • Kharraz, Yacine; Guerra, Joana; Pessina, Patrizia; Serrano, Antonio L.; Muñoz Cánoves, Pura, 1962- (Hindawi, 2014)
    Fibrosis is the aberrant deposition of extracellular matrix (ECM) components during tissue healing leading to loss of its architecture and function. Fibrotic diseases are often associated with chronic pathologies and occur ...