Browsing by Author "Maldonado, Rafael, 1961-"

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  • Valverde Granados, Olga; Maldonado, Rafael, 1961-; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Flores de los Heros, África, 1985-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Frontiers, 2013)
    Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical ...
  • Aso Pérez, Ester; Sánchez Pla, Alexandre; Vegas Lozano, Esteban; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2015)
    Several recent findings suggest that targeting the endogenous cannabinoid system can be considered as a potential therapeutic approach to treat Alzheimer's disease (AD). The present study supports this hypothesis demonstrating ...
  • Aso Pérez, Ester; Palomer, Ernest; Juvés, Salvador; Maldonado, Rafael, 1961-; Muñoz López, Francisco José, 1964-; Ferrer, Isidre (IOS Press, 2012)
    The present study shows that chronic administration of the cannabinoid receptor type 1 (CB1) receptor agonist arachidonyl-2-chloroethylamide (ACEA) at pre-symptomatic or at early symptomatic stages, at a non-amnesic dose, ...
  • Touriño Raposo, Clara; Ledent, Catherine; Maldonado, Rafael, 1961-; Valverde Granados, Olga (Elsevier, 2008)
    Background: 3, 4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug widely abused by young people. The endocannabinoid system is involved in the addictive processes induced by different drugs of abuse. ...
  • Saravia, Rocío; Flores de los Heros, África, 1985-; Plaza-Zabala, Ainhoa, 1982-; Busquets Garcia, Arnau, 1985-; Pastor, Antonio; Torre Fornell, Rafael de la; Di Marzo, Vicenzo; Marsicano, Giovanni; Ozaita Mintegui, Andrés, 1969-; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2017)
    BACKGROUND: Tobacco withdrawal is associated with deficits in cognitive function, including attention, working memory, and episodic memory. Understanding the neurobiological mechanisms involved in these effects is crucial ...
  • Mato, Susana; Aso Pérez, Ester; Castro, Elena; Martín, Miguel; Valverde Granados, Olga; Maldonado, Rafael, 1961-; Pazos, Ángel (Wiley-Blackwell, 2007)
    Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioural and biochemical responses in CB1 receptor knockout mice. CB1 knockout animals exhibited ...
  • Aso Pérez, Ester; Juvés, Salvador; Maldonado, Rafael, 1961-; Ferrer, Isidre (IOS Press, 2013)
    The specific CB2 cannabinoid receptor agonist JWH-133 induced cognitive improvement in double AβPP/PS1 transgenic mice, a genetic model of Alzheimer's disease. This effect was more pronounced when administered at the ...
  • Kossatz, Elk; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Elsevier, 2016)
    The role of CB2 cannabinoid receptors (CB2R) in global brain lesions induced by hypoxia-ischemia (HI) insult is still unresolved. The aim of this study was to evaluate the involvement of CB2R in the behavioural and biochemical ...
  • Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Royal Society, 2012)
    Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds ...
  • Matrov, Denis; Kaart, Tanel; Lanfumey, Laurence; Maldonado, Rafael, 1961-; Sharp, Trevor; Tordera, Rosa M.; Kelly, Paul A.; Deakin, Bill; Harro, Jaanus (Elsevier, 2019)
    The psychopathology of depression is highly complex and the outcome of studies on animal models is divergent. In order to find brain regions that could be metabolically distinctively active across a variety of mouse ...
  • Viñals, Xavier; Moreno, Estefanía; Lanfumey, Laurence; Cordomí, Arnau; Pastor, Antonio; Torre Fornell, Rafael de la; Gasperini, Paola; Navarro, Gemma; Howell, Lesley A.; Pardo, Leonardo; Lluís, Carmen; Canela, Enric I.; McCormick, Peter J.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958- (Public Library of Science, 2015)
    Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in cannabis users that constitute important drawbacks for the use of ...
  • Guegan, Thomas, 1983- (Universitat Pompeu Fabra, 2013-11-05)
    Drug addiction and some eating disorders present striking similarities in their behavioural symptoms. It has been postulated that excessive consumption of drugs of abuse and palatable food could lead to the development of ...
  • Saravia, Rocío; Ten-Blanco, Marc; Julià Hernández, Marina; Gagliano, Humberto; Andero, Raül; Armario García, Antonio; Maldonado, Rafael, 1961-; Berrendero Díaz, Fernando, 1971- (Elsevier, 2019)
    Δ9-tetrahydrocannabinol (THC) consumption during adolescence is reported to be a risk factor for the appearance of psychiatric disorders later in life. The interaction between genetic or environmental events and cannabinoid ...
  • Racz, Ildiko; Nadal i Roura, Xavier, 1980-; Alferink, Judith; Baños i Díez, Josep Eladi; Rehnelt, Jennifer; Martín Sánchez, Miquel, 1971-; Pintado, Belén; Gutierrez-Adan, Alfonso; Sanguino, Elena; Manzanares, Jorge; Zimmer, Andreas; Maldonado, Rafael, 1961- (Society for Neuroscience, 2008)
    Neuropathic pain is a clinical manifestation of nerve injury difficult to treat even with potent analgesic compounds. Here, we used different lines of genetically modified mice to clarify the role played by CB2 cannabinoid ...
  • Aso Pérez, Ester; Maldonado, Rafael, 1961-; Murtra, Patricia; Balerio, Graciela N.; Berrendero Díaz, Fernando, 1971- (Wiley-Blackwell, 2004)
    The possible interactions between Delta9-tetrahydrocannabinol (THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the ...
  • Salgado Mendialdúa, Victòria; Aguirre Plans, Joaquim; Guney, Emre; Reig-Viader, Rita; Maldonado, Rafael, 1961-; Bayés, Angels; Oliva Miguel, Baldomero; Ozaita Mintegui, Andrés, 1969- (Elsevier, 2018)
    Cannabis is the most consumed illicit drug worldwide. Its principal psychoactive component, Δ9-tetrahydrocannabinol (THC), affects multiple brain functions, including cognitive performance, by modulating cannabinoid type-1 ...
  • Martín García, Elena, 1975-; Bourgoin, Lucie; Cathala, Adeline; Kasanetz, Fernando; Mondesir, Miguel; Gutiérrez-Rodríguez, Ana; Reguero, Leire; Fiancette, Jean-François; Grandes, Pedro; Spampinato, Umberto; Maldonado, Rafael, 1961-; Piazza, Pier Vincenzo; Marsicano, Giovanni; Deroche-Gamonet, Véronique (Nature Publishing Group, 2016)
    The type 1 cannabinoid receptor (CB1) modulates numerous neurobehavioral processes and is therefore explored as a target for the treatment of several mental and neurological diseases. However, previous studies have ...
  • Georgiou, Polymnia; Zanos, Panos; Ehteramyan, Mazdak; Hourani, Susanna; Kitchen, Ian; Maldonado, Rafael, 1961-; Bailey, Alexis (Wiley, 2015)
    The key problem for the treatment of drug addiction is relapse to drug use after abstinence that can be triggered by drug-associated cues, re-exposure to the drug itself and stress. Understanding the neurobiological ...
  • Puighermanal Puigvert, Emma, 1983-; Busquets Garcia, Arnau, 1985-; Gomis González, Maria; Marsicano, Giovanni; Maldonado, Rafael, 1961-; Ozaita Mintegui, Andrés, 1969- (Nature Publishing Group, 2013)
    The potential therapeutic benefits of cannabinoid compounds have raised interest in understanding the molecular mechanisms that underlie cannabinoid-mediated effects. We previously showed that the acute amnesic-like effects ...