File contents ----------------- Protein_Drug_Interactions.tsv Interactions of 96/475 cancer driver genes in Drivers Database with therapeutic agents Protein_druggability.tsv Exclusvie druggability of 157/475 driver genes according interactions in Protein_Drug_Interactions.tsv Drug_details.tsv Description of each drug Drug_FDAapproved_rules.tsv Rules for prescription of FDA approved drugs to genomic alterations Drug_ClinicalTrials_rules.tsv Rules for prescription of drugs in clinical trials to genomic alterations Drug_resistances_rules.tsv Rules for not prescribing drugs to samples bearing genomic alterations of primary resistance Specificities ----------------- *In most of the files tumor types are represented through its acronyms (see Drivers Database) *Specific genomic dependencies/evidences/resistances are codified in the same unified code in the Columns () in the files (Drug_resistances_rules.tsv, Drug_FDAapproved_rules.tsv, Drug_ClinicalTrials_rules.tsv). The coding rules are: - All of them are divided in mutations/CNAs/fusions. - For each one, different genes with alterations are semicolon (;) divided. - Each gene differs from its alterions with colon(:) and its different alterations are comma (,) divided. i.e BRAF:V600E,V600K (two diferent alterations) - For CNAs A stants for Amplification and D for delention. i.e. FGFR1:A - For mutations all of them are specified at protein level lik referenceAA+proteinposition+alteredAA. i.e. BRAF:V600E,V600K except mutational requirements not based on AA change but specific consequence type, which are specified by ::CT:: after the gene. i.e. NOTCH1::CT::missense_variant:2380-2445;CT::feature_truncation:2380-2445 - Fusion partners are divided with dash (-). i.e. BCR-ABL1 - A dot (.) represents any. i.e. BRAF:V600. (any alteredAA) i.e. BRAF:. (any PAM mutation)