# # This file lists the High Confidence Drivers identified as part of the pan-cancer12 initiative, published in the paper # "Comprehensive identification of mutational cancer driver genes across 12 tumor types" Scientific Reports 3:2650 doi:10.1038/srep02650, 2013 # # Columns names # ## Gene Symbol: High-Confidence Driver gene ## Cancer Gene Census: The gene is already part of the Cancer Gene Census ## MuSIC: The gene was identified recurrently mutated by MuSIC (Nature 502, 333–339) ## OncodriveFM: The gene was identified as FM biased by OncodriveFM (Nucleic Acids Research. 2012. 1-10. 10.1093/nar/gks743) ## OncodriveCLUST: The gene was identified with mutations significantly clustered by OncodriveCLUST (Bioinformatics. 2013; doi: 10.1093/bioinformatics/btt395s) ## ActiveDriver: The gene was identified with muttaions enriched for phosphorilation motifs (Scientific Reports 3,Article number: 2651 doi:10.1038/srep02651) ## MutSig: The gene was identified as significantly mutated by MutSig (Nature 499, 214–218) # Gene Symbol Cancer Gene Census MuSIC OncodriveFM OncodriveCLUST ActiveDriver MutSig Putative Driver Category AARS2 Selected High Confidence Driver ABCB1 Selected Selected Selected High Confidence Driver ABL1 CGC Selected High Confidence Driver ACVR1B Selected Selected High Confidence Driver ADAM10 Selected High Confidence Driver ADCY1 Selected High Confidence Driver ADORA2A Selected High Confidence Driver AHNAK2 Selected Selected High Confidence Driver AJUBA Selected Selected High Confidence Driver AKAP9 CGC Selected Selected High Confidence Driver AKD1 Selected High Confidence Driver AKT1 CGC Selected Selected Selected Selected High Confidence Driver AMPH Selected High Confidence Driver ANAPC1 Selected High Confidence Driver ANKRD12 Selected Selected High Confidence Driver APAF1 Selected High Confidence Driver APC CGC Selected Selected Selected Selected High Confidence Driver AR Selected High Confidence Driver ARHGAP32 Selected High Confidence Driver ARHGAP35 Selected Selected High Confidence Driver ARHGEF6 Selected High Confidence Driver ARID1A CGC Selected Selected Selected High Confidence Driver ARID2 CGC Selected Selected High Confidence Driver ARID5B Selected Selected High Confidence Driver ASPM Selected Selected High Confidence Driver ASXL1 CGC Selected Selected High Confidence Driver ATG13 Selected High Confidence Driver ATM CGC Selected Selected Selected High Confidence Driver ATR Selected Selected High Confidence Driver ATRX CGC Selected Selected Selected Selected High Confidence Driver AXIN2 Selected Selected High Confidence Driver B2M Selected Selected Selected High Confidence Driver BAP1 CGC Selected Selected Selected High Confidence Driver BARD1 Selected High Confidence Driver BCLAF1 Selected Selected High Confidence Driver BCOR CGC Selected High Confidence Driver BLM CGC Selected Selected High Confidence Driver BRAF CGC Selected Selected Selected Selected High Confidence Driver BRCA1 CGC Selected Selected Selected High Confidence Driver BRCA2 CGC Selected Selected Selected High Confidence Driver BUB1B CGC Selected High Confidence Driver CAD Selected High Confidence Driver CARM1 Selected High Confidence Driver CASP8 Selected Selected Selected Selected High Confidence Driver CAST Selected Selected High Confidence Driver CBFB CGC Selected Selected Selected Selected High Confidence Driver CCAR1 Selected High Confidence Driver CCND1 CGC Selected Selected Selected Selected High Confidence Driver CDC73 CGC Selected High Confidence Driver CDH1 CGC Selected Selected Selected High Confidence Driver CDK12 CGC Selected Selected Selected Selected High Confidence Driver CDKN1A Selected Selected Selected High Confidence Driver CDKN1B Selected Selected Selected High Confidence Driver CDKN2A CGC Selected Selected Selected Selected High Confidence Driver CDKN2C CGC Selected High Confidence Driver CEBPA CGC Selected Selected Selected High Confidence Driver CFH Selected Selected High Confidence Driver CHD4 Selected Selected High Confidence Driver CHD8 Selected High Confidence Driver CHEK2 CGC Selected Selected Selected High Confidence Driver CIC CGC Selected High Confidence Driver CLIP1 Selected High Confidence Driver CLTC CGC Selected High Confidence Driver CLTCL1 CGC Selected High Confidence Driver COL18A1 Selected High Confidence Driver CREB1 CGC Selected High Confidence Driver CRTC1 CGC Selected High Confidence Driver CRTC3 CGC Selected High Confidence Driver CSDE1 Selected High Confidence Driver CTCF Selected Selected Selected Selected Selected High Confidence Driver CTNNB1 CGC Selected Selected Selected Selected Selected High Confidence Driver CTNND1 Selected High Confidence Driver CTTN Selected High Confidence Driver CUL1 Selected High Confidence Driver CYLD CGC Selected High Confidence Driver DDX5 CGC Selected High Confidence Driver DHX9 Selected High Confidence Driver DICER1 CGC Selected High Confidence Driver DMD Selected Selected High Confidence Driver DNMT3A CGC Selected Selected Selected Selected High Confidence Driver DOCK2 Selected High Confidence Driver EEF1A1 Selected Selected High Confidence Driver EGFR CGC Selected Selected Selected Selected Selected High Confidence Driver EIF4A2 CGC Selected High Confidence Driver ELF3 Selected Selected Selected High Confidence Driver EP300 CGC Selected Selected Selected High Confidence Driver ERBB2 CGC Selected Selected Selected High Confidence Driver ERBB2IP Selected High Confidence Driver ERCC2 CGC Selected Selected Selected High Confidence Driver ESR1 Selected High Confidence Driver EWSR1 CGC Selected High Confidence Driver EZH2 CGC Selected High Confidence Driver FANCA CGC Selected High Confidence Driver FBN2 Selected Selected High Confidence Driver FBXO11 CGC Selected High Confidence Driver FBXW7 CGC Selected Selected Selected Selected High Confidence Driver FES Selected High Confidence Driver FGFR2 CGC Selected Selected Selected Selected High Confidence Driver FGFR3 CGC Selected Selected Selected Selected High Confidence Driver FLT3 CGC Selected Selected Selected Selected Selected High Confidence Driver FN1 Selected High Confidence Driver FOXA1 Selected Selected High Confidence Driver FOXA2 Selected Selected Selected High Confidence Driver FRG1B Selected Selected Selected High Confidence Driver GATA3 CGC Selected Selected Selected High Confidence Driver GNAI1 Selected High Confidence Driver GNAS CGC Selected Selected High Confidence Driver GOLGA5 CGC Selected Selected High Confidence Driver GOT2 Selected Selected High Confidence Driver GPHN CGC Selected High Confidence Driver GPS2 Selected Selected High Confidence Driver GTF2H1 Selected High Confidence Driver H3F3C Selected Selected High Confidence Driver HGF Selected High Confidence Driver HLA-A Selected Selected Selected High Confidence Driver HLA-B Selected Selected High Confidence Driver HMGXB4 Selected Selected High Confidence Driver HRAS CGC Selected Selected Selected High Confidence Driver HSP90AB1 CGC Selected High Confidence Driver HSPA8 Selected High Confidence Driver HUWE1 Selected High Confidence Driver IDH1 CGC Selected Selected Selected Selected Selected High Confidence Driver IDH2 CGC Selected Selected Selected Selected Selected High Confidence Driver IRS2 Selected High Confidence Driver ITGA6 Selected High Confidence Driver JAK2 CGC Selected High Confidence Driver KALRN Selected High Confidence Driver KDM5C CGC Selected Selected Selected High Confidence Driver KDM6A CGC Selected Selected Selected Selected High Confidence Driver KEAP1 Selected Selected Selected Selected High Confidence Driver KIAA1109 Selected Selected High Confidence Driver KIFC3 Selected High Confidence Driver KIT CGC Selected Selected Selected Selected High Confidence Driver KRAS CGC Selected Selected Selected Selected High Confidence Driver LCP1 CGC Selected High Confidence Driver LEPR Selected Selected High Confidence Driver LIFR CGC Selected High Confidence Driver LPP CGC Selected High Confidence Driver LRRK2 Selected Selected High Confidence Driver LUM Selected Selected High Confidence Driver LYN Selected High Confidence Driver LZTR1 Selected Selected High Confidence Driver MALAT1 CGC Selected High Confidence Driver MAP2K4 CGC Selected Selected Selected Selected High Confidence Driver MAP3K1 Selected Selected Selected High Confidence Driver MAP3K3 Selected High Confidence Driver MAP3K4 Selected High Confidence Driver MAPK8IP1 Selected High Confidence Driver MAST2 Selected Selected High Confidence Driver MATK Selected High Confidence Driver MAX Selected Selected High Confidence Driver MDC1 Selected High Confidence Driver MECOM CGC Selected High Confidence Driver MED12 CGC Selected High Confidence Driver MED13 Selected High Confidence Driver MED17 Selected High Confidence Driver MEF2A Selected High Confidence Driver METTL14 Selected Selected Selected High Confidence Driver MLL CGC Selected Selected High Confidence Driver MLL2 CGC Selected Selected Selected Selected High Confidence Driver MLL3 CGC Selected Selected Selected High Confidence Driver MLLT10 CGC Selected High Confidence Driver MLLT3 CGC Selected High Confidence Driver MLLT4 CGC Selected Selected High Confidence Driver MMP2 Selected High Confidence Driver MN1 CGC Selected High Confidence Driver MSN CGC Selected High Confidence Driver MST1 Selected High Confidence Driver MTOR Selected Selected High Confidence Driver MYB CGC Selected Selected High Confidence Driver MYH9 CGC Selected Selected High Confidence Driver NAV3 Selected Selected High Confidence Driver NBPF10 Selected Selected High Confidence Driver NCOA3 Selected Selected High Confidence Driver NCOA4 CGC Selected High Confidence Driver NCOR1 Selected Selected Selected High Confidence Driver NCOR2 Selected High Confidence Driver NEB Selected Selected High Confidence Driver NEDD4L Selected High Confidence Driver NF1 CGC Selected Selected Selected High Confidence Driver NFE2L2 CGC Selected Selected Selected Selected Selected High Confidence Driver NIN CGC Selected High Confidence Driver NLRP3 Selected High Confidence Driver NONO CGC Selected High Confidence Driver NOTCH1 CGC Selected Selected Selected High Confidence Driver NPM1 CGC Selected Selected Selected High Confidence Driver NR1H2 Selected High Confidence Driver NR4A2 Selected High Confidence Driver NRAS CGC Selected Selected Selected Selected Selected High Confidence Driver NSD1 CGC Selected Selected High Confidence Driver NUMA1 CGC Selected Selected High Confidence Driver NUP214 CGC Selected High Confidence Driver NUP93 Selected High Confidence Driver NUP98 CGC Selected High Confidence Driver PABPC1 Selected High Confidence Driver PBRM1 CGC Selected Selected Selected High Confidence Driver PCBP1 Selected Selected High Confidence Driver PCM1 CGC Selected High Confidence Driver PDGFRA CGC Selected Selected High Confidence Driver PHF6 CGC Selected Selected Selected High Confidence Driver PHLDA1 Selected Selected High Confidence Driver PIK3CA CGC Selected Selected Selected Selected High Confidence Driver PIK3CB Selected High Confidence Driver PIK3CG Selected High Confidence Driver PIK3R1 CGC Selected Selected Selected Selected Selected High Confidence Driver PIP5K1A Selected High Confidence Driver PLCG1 Selected High Confidence Driver PLEC Selected Selected High Confidence Driver POTEF Selected Selected High Confidence Driver PPP2R1A CGC Selected Selected Selected Selected High Confidence Driver PRKAR1A CGC Selected High Confidence Driver PRKCD Selected High Confidence Driver PRPF8 Selected High Confidence Driver PSEN1 Selected High Confidence Driver PTEN CGC Selected Selected Selected Selected Selected High Confidence Driver PTPN11 CGC Selected Selected Selected Selected High Confidence Driver RAC1 Selected Selected Selected High Confidence Driver RAD21 Selected High Confidence Driver RANBP2 Selected High Confidence Driver RANBP3 Selected High Confidence Driver RASA1 Selected Selected Selected High Confidence Driver RB1 CGC Selected Selected Selected High Confidence Driver RBMX Selected High Confidence Driver RHEB Selected High Confidence Driver RHOA Selected High Confidence Driver RNF213 CGC Selected High Confidence Driver RNF43 Selected High Confidence Driver RPGR Selected High Confidence Driver RPL22 CGC Selected Selected High Confidence Driver RPL5 Selected Selected Selected High Confidence Driver RPSAP58 Selected Selected Selected High Confidence Driver RUNX1 CGC Selected Selected Selected Selected High Confidence Driver RXRA Selected High Confidence Driver SETD2 CGC Selected Selected Selected High Confidence Driver SF3B1 CGC Selected Selected Selected High Confidence Driver SGK1 Selected High Confidence Driver SIN3A Selected High Confidence Driver SMAD2 Selected Selected Selected High Confidence Driver SMAD4 CGC Selected Selected Selected Selected High Confidence Driver SMARCA4 CGC Selected Selected High Confidence Driver SMC1A Selected Selected High Confidence Driver SMC3 Selected Selected High Confidence Driver SOS1 Selected High Confidence Driver SOX17 Selected Selected High Confidence Driver SPATA6 Selected Selected High Confidence Driver SPEN Selected Selected High Confidence Driver SPOP Selected Selected Selected Selected High Confidence Driver STAG2 Selected Selected Selected High Confidence Driver STAT3 Selected High Confidence Driver STK11 CGC Selected Selected Selected High Confidence Driver SUZ12 CGC Selected Selected High Confidence Driver SYNE1 Selected Selected High Confidence Driver TAF1 Selected Selected High Confidence Driver TBL1XR1 Selected Selected High Confidence Driver TBX3 Selected Selected Selected High Confidence Driver TCF12 CGC Selected High Confidence Driver TCF7 Selected High Confidence Driver TCF7L2 CGC Selected Selected High Confidence Driver TET2 CGC Selected Selected Selected High Confidence Driver TFDP1 Selected High Confidence Driver TGFBR2 Selected Selected High Confidence Driver TGIF1 Selected High Confidence Driver TJP2 Selected High Confidence Driver TNFRSF10C Selected High Confidence Driver TOM1 Selected High Confidence Driver TOP3A Selected High Confidence Driver TP53 CGC Selected Selected Selected Selected Selected High Confidence Driver TP53BP1 Selected Selected High Confidence Driver TPR CGC Selected High Confidence Driver TRIM7 Selected High Confidence Driver TRIO Selected High Confidence Driver TRIP11 CGC Selected High Confidence Driver TSC2 CGC Selected High Confidence Driver TUBA1A Selected High Confidence Driver TXNIP Selected Selected High Confidence Driver U2AF1 CGC Selected Selected Selected Selected High Confidence Driver UHRF1BP1L Selected High Confidence Driver VHL CGC Selected Selected Selected Selected Selected High Confidence Driver WHSC1 CGC Selected Selected High Confidence Driver WHSC1L1 CGC Selected High Confidence Driver WRN CGC Selected High Confidence Driver WT1 CGC Selected Selected Selected Selected High Confidence Driver ZFHX3 Selected Selected Selected High Confidence Driver ZFP36L1 Selected Selected Selected High Confidence Driver ZFP36L2 Selected Selected High Confidence Driver ZMYM2 CGC Selected High Confidence Driver ZNF132 Selected High Confidence Driver ZNF300 Selected High Confidence Driver ZNF814 Selected Selected High Confidence Driver ZNF844 Selected Selected High Confidence Driver ZNF91 Selected Selected High Confidence Driver