• A new assemblage of late Neanderthal remains from Cova Simanya (NE Iberia)

  Morales, Juan I.; Cebrià, Artur; Soto, María; Rodríguez-Hidalgo, Antonio; Hernando, Raquel; Moreno-Ribas, Elena; Lombao, Diego; Rabuñal, José R.; Martín-Perea, David M.; García-Tabernero, Antonio; Allué, Ethel; García Basanta, Andrea; Lizano González, Esther, 1974-; Marquès i Bonet, Tomàs, 1975-; Talamo, Sahra; Tassoni, Laura; Lalueza Fox, Carles, 1965-; Fullola, Josep M.; Rosas, Antonio (Frontiers, 2023)

  This study presents an exceptional collection of 54 Late Pleistocene human remains that correspond to at least three Neanderthal individuals from Simanya Gran, the main gallery of Cova Simanya, located in the northeastern ...
• Increased paclitaxel recovery from Taxus baccata vascular stem cells using novel in situ product recovery approaches

  Santoyo-Garcia, Jorge H.; Valdivia-Cabrera, Marissa; Ochoa-Villarreal, Marisol; Casasola-Zamora, Samuel; Ripoll, Magdalena; Escrich Montañana, Ainoa; Moyano Claramunt, Elisabet; Betancor, Lorena; Halliday, Karen J.; Loake, Gary J.; Rios-Solis, Leonardo (Springer, 2023)

  In this study, several approaches were tested to optimise the production and recovery of the widely used anticancer drug Taxol® (paclitaxel) from culturable vascular stem cells (VSCs) of Taxus baccata, which is currently ...
• Classification system for nanotechnology-enabled health products with both scientific and regulatory application

  Rodríguez-Gómez, Francisco D.; Penon, Oriol; Monferrer, Dominique; Rivera Gil, Pilar, 1976- (Frontiers, 2023)

  The lack of specific regulatory guidelines for nanotechnology-enabled health products (NHPs) is hampering development and patient access to these innovative technologies. Namely, there is an urgent need for harmonized ...
• Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions

  Maury, Eduardo A.; Brain Somatic Mosaicism Network; Walsh, Christopher A. (Elsevier, 2023)

  While germline copy-number variants (CNVs) contribute to schizophrenia (SCZ) risk, the contribution of somatic CNVs (sCNVs)-present in some but not all cells-remains unknown. We identified sCNVs using blood-derived genotype ...
• A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

  Coto-Segura, Pablo; Segú-Vergés, Cristina; Martorell, Antonio; Moreno-Ramírez, David; Jorba Argemí, Guillem; Junet, Valentin; Guerri, Filippo; Daura, Xavier; Oliva Miguel, Baldomero; Cara, Carlos; Suárez-Magdalena, Olaya; Abraham, Sonya; Mas, José Manuel (Frontiers, 2023)

  Background: Psoriasis is a chronic immune-mediated inflammatory systemic disease with skin manifestations characterized by erythematous, scaly, itchy and/or painful plaques resulting from hyperproliferation of keratinocytes. ...

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