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Visualitza Articles (Departament de Medicina i Ciències de la Vida) per matèria "Genètica molecular"

Ara mostrant els elements 1-10 de 10

Cancer type-dependent genetic interactions between cancer driver alterations indicate plasticity of epistasis across cell types

Park, Solip; Lehner, Ben, 1978- (Wiley Blackwell, 2015)

Cancers, like many diseases, are normally caused by combinations of genetic alterations rather than by changes affecting single genes. It is well established that the genetic alterations that drive cancer often interact ...
Comparative analysis of cancer genes in the human and chimpanzee genomes

Puente, Xosé S.; Velasco, Gloria; Gutiérrez Fernández, Ana; Bertranpetit, Jaume, 1952-; King, Mary Claire; López Otín, Carlos (BioMed Central, 2006)

Background: Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribute ...
Drosha regulates gene expression independently of RNA cleavage function

Gromak, Natalia; Dienstbier, Martin; Macias, Sara; Plass Pórtulas, Mireya, 1982-; Eyras Jiménez, Eduardo; Cáceres, Javier F.; Proudfoot, Nicholas J. (Elsevier, 2013)

Drosha is the main RNase III-like enzyme involved in the process of microRNA (miRNA) biogenesis in the nucleus. Using whole-genome ChIP-on-chip analysis, we demonstrate that, in addition to miRNA sequences, Drosha specifically ...
Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility

Solé, Xavier; Hernández, Pilar; López de Heredia, Miguel de; Armengol i Dulcet, Lluís; Rodríguez Santiago, Benjamín; Gómez, Laia; Maxwell, Christopher A.; Aguilo, Fernando; Condom, Enric; Abril, Jesús; Pérez Jurado, Luis Alberto; Estivill, Xavier, 1955-; Nunes, Virginia; Capellá, Gabriel; Gruber, Stephen B.; Moreno, Víctor; Pujana, Miguel Angel (BioMed Central, 2008)

Background: Germline genetic variation is associated with the differential expression of many human genes. The phenotypic effects of this type of variation may be important when considering susceptibility to common genetic ...
IG/MYC rearrangements are the main cytogenetic alteration in plasmablastic lymphomas

Valera, Alexandra; Balagué, Olga; Colomo Saperas, Luis Alberto; Martínez García, Antonio; Delabie, Jan; Taddesse-Heath, Lekidelu; Jaffe, Elaine S.; Campo, Elias (Lippincott Williams & Wilkins, 2010)

Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in the immunocompromised or elderly patients. Although the clinical and pathologic ...
Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses

Hurle, Belen; Marquès i Bonet, Tomàs, 1975-; Antonacci, Francesca; Hughes, Inna; Ryan, Joseph F.; NISC Comparative Sequencing Program; Eichler, Evan E.; Ornitz, David M.; Green, Eric D. (BioMed Central, 2011)

Background: Mutations in the Otopetrin 1 gene (Otop1) in mice and fish produce an unusual bilateral vestibular pathology that involves the absence of otoconia without hearing impairment. The encoded protein, Otop1, is the ...
Maternal co-ordinate gene regulation and axis polarity in the scuttle fly Megaselia abdita

Wotton, Karl R.; Jiménez Guri, Eva; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2015)

Axis specification and segment determination in dipteran insects are an excellent model system for comparative analyses of gene network evolution. Antero-posterior polarity of the embryo is established through systems of ...
Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita

Karl R., Wotton; Jiménez Guri, Eva; Crombach, Anton; Janssens, Hilde; Alcaine Colet, Anna, 1992-; Lemke, Steffen; Schmidt Ott, Urs; Jaeger, Johannes, 1973- (eLife, 2015)

The segmentation gene network in insects can produce equivalent phenotypic outputs despite differences in upstream regulatory inputs between species. We investigate the mechanistic basis of this phenomenon through a ...
Structural and functional properties of genes involved in human cancer

Furney, Simon J.; Higgins, Desmond G.; Ouzounis, Christos A.; López Bigas, Núria (BioMed Central, 2006)

Background: One of the main goals of cancer genetics is to identify the causative elements at the molecular level leading to cancer./nResults: We have conducted an analysis of a set of genes known to be involved in cancer ...
The tomato genome sequence provides insights into fleshy fruit evolution

Tomato Genome Consortium; Sato, S.; Guigó Serra, Roderic; Cámara, Francisco; Gianese, S. (Nature Publishing Group, 2012)

Tomato (Solanum lycopersicum) is a major crop plant and a model system for fruit development. Solanum is one of the largest angiosperm genera and includes annual and perennial plants from diverse habitats. Here we present ...