Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Subject "Cannabinoides -- Receptors"

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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Subject "Cannabinoides -- Receptors"

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  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, M. Patricia; Hahn, Heidi; Valverde, Olga; Maldonado, Rafael (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Aso Pérez, Ester; Valverde Granados, Olga; Ozaita Mintegui, Andrés; Maldonado, Rafael; Pazos, Ángel; Ledent, Catherine; Valdizán, Elsa M. (Wiley-Blackwell, 2008)
    Stress can cause damage and atrophy of neurons in the hippocampus by deregulating the expression of neurotrophic factors that promote neuronal plasticity. The endocannabinoid system represents a physiological substrate ...
  • Maldonado, Rafael; Rodríguez de Fonseca, Fernando (Society for Neuroscience, 2002)
    The use of cannabis sativa preparations as recreational drugs can be traced back to the earliest civilizations. However, animal models of cannabinoid addiction allowing the exploration of neural correlates of cannabinoid ...
  • Valverde, Olga; Maldonado, Rafael; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Aso Pérez, Ester; Pazos, Ángel; Mato, Susana; Maldonado, Rafael; Valverde Granados, Olga; Martín, Miquel; Castro, Elena (Wiley-Blackwell, 2007)
    Interaction between brain endocannabinoid (EC) and serotonin (5-HT) systems was investigated by examining 5-HT-dependent behavioural and biochemical responses in CB1 receptor knockout mice. CB1 knockout animals exhibited ...
  • Racz, Ildiko; Nadal, Xavier; Alferink, Judith; Baños i Díez, Josep Eladi; Rehnelt, Jennifer; Martín, Miquel; Pintado, Belén; Gutierrez-Adan, Alfonso; Sanguino, Elena; Manzanares, Jorge; Zimmer, Andreas; Maldonado, Rafael (Society for Neuroscience, 2008)
    Neuropathic pain is a clinical manifestation of nerve injury difficult to treat even with potent analgesic compounds. Here, we used different lines of genetically modified mice to clarify the role played by CB2 cannabinoid ...
  • Aso Pérez, Ester; Maldonado, Rafael; Murtra, Patricia; Balerio, Graciela N.; Berrendero Díaz, Fernando (Wiley-Blackwell, 2004)
    The possible interactions between Delta9-tetrahydrocannabinol (THC) and nicotine remain unclear in spite of the current association of cannabis and tobacco in humans. The aim of the present study was to explore the ...
  • Racz, Ildiko; Nadal, Xavier; Alferink, Judith; Baños i Díez, Josep Eladi; Rehnelt, Jennifer; Martín, Miquel; Pintado, Belén; Gutierrez-Adan, Alfonso; Sanguino, Elena; Bellora Pereyra, Nicolás; Manzanares, Jorge; Zimmer, Andreas; Maldonado, Rafael (Society for Neuroscience, 2008)
    Nerve injuries often lead to neuropathic pain syndrome. The mechanisms contributing to this syndrome involve local inflammatory responses, activation of glia cells, and changes in the plasticity of neuronal nociceptive ...
  • Aso Pérez, Ester; Renoir, Thibault; Valverde Granados, Olga; Lanfumey, Laurence; Maldonado, Rafael; Hamon, Michel; Ledent, Catherine; Mengod, Guadalupe (Wiley-Blackwell, 2009)
    Serotonergic and endocannabinoid systems are important substrates for the control of emotional behavior and growing evidence show an involvement in the pathophysiology of mood disorders. In the present study, the absence ...
  • Ghozland, Sandy; Matthes, Hans W. D.; Simonin, Frederic; Filliol, Dominique; Kieffer, Brigitte L.; Maldonado, Rafael (Society for Neuroscience, 2002)
    Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possible relationship with the ...
  • Aso Pérez, Ester; Balerio, Graciela N.; Maldonado, Rafael (Springer, 2006)
    Rationale: Acute behavioural effects and motivational responses induced by nicotine can be modulated by the endocannabinoid system supporting the existence of a physiological interaction between these two systems. Objectives: ...

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