Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Issue Date

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Browsing Articles (Departament de Ciències Experimentals i de la Salut) by Issue Date

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  • Fickett, James W.; Guigó Serra, Roderic (Oxford University Press, 1993)
    A number of experimental methods have been reported for estimating the number of genes in a genome, or the closely related coding density of a genome, defined as the fraction of base pairs in codons. Recently, DNA sequence ...
  • Guigó Serra, Roderic (Centre de Supercomputació de Catalunya, 1995)
  • Guigó Serra, Roderic (Mary Ann Liebert, Inc, 1998)
    In a number of programs for gene structure prediction in higher eukaryotic genomic sequences, exon prediction is decoupled from gene assembly: a large pool of candidate exons is predicted and scored from features located ...
  • Álvarez, Alejandra; Alarcón, Rodrigo; Opazo, Carlos; Campos, Eliseo O.; Muñoz López, Francisco José; Calderón, Frances H.; Dajas, Federico; Gentry, Mary K.; Doctor, Bhupendra P.; Mello, Fernando G. de; Inestrosa, Nibaldo C. (Society for Neuroscience, 1998)
    Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (Abeta) during its assembly into filaments, in agreement with its colocalization with the Abeta deposits of Alzheimer's brain. The association ...
  • Matthes, Hans W. D.; Smadja, C.; Valverde, Olga; Vonesch, J. L.; Foutz, A. S.; Boudinot, E.; Denavit-Saubié, M.; Severini, Cintia; Negri, Lucia; Roques, B. P.; Maldonado, Rafael; Kieffer, Brigitte L. (Society for Neuroscience, 1998)
    Previous pharmacological studies have indicated the possible existence of functional interactions between μ-, δ- and κ-opioid receptors in the CNS. We have investigated this issue using a genetic approach. Here we describe ...
  • Chow, Alan; Erisir, A.; Farb, C.; Nadal, M. S.; Ozaita Mintegui, Andrés; Lau, David; Welker, E.; Rudy, Bernardo (Society for Neuroscience, 1999)
    Kv3.1 and Kv3.2 K+ channel proteins form similar voltage-gated K+ channels with unusual properties, including fast activation at voltages positive to −10 mV and very fast deactivation rates. These properties are thought ...
  • Lau, David; Vega-Saenz de Miera, Eleazar; Contreras, Diego; Ozaita Mintegui, Andrés; Harvey, Michael; Chow, Alan; Noebels, Jeffrey L.; Paylor, Richard; Morgan, James I.; Leonard, Christopher S.; Rudy, Bernardo (Society for Neuroscience, 2000)
    Voltage-gated K+ channels of the Kv3 subfamily have unusual electrophysiological properties, including activation at very depolarized voltages (positive to −10 mV) and very fast deactivation rates, suggesting special roles ...
  • Valjent, Emmanuel; Corvol, Jean-Christophe; Pagès, Christiane; Besson, Marie-J.; Maldonado, Rafael; Caboche, Jocelyne (Society for Neuroscience, 2000)
    A central feature of drugs of abuse is to induce gene expression in discrete brain structures that are critically involved in behavioral responses related to addictive processes. Although extracellular signal-regulated ...
  • Parra Farré, Genís; Blanco, Enrique; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2000)
    GeneID is a program to predict genes in anonymous genomic sequences designed with a hierarchical structure. In the first step, splice sites, and start and stop codons are predicted and scored along the sequence using ...
  • Guigó Serra, Roderic; Agarwal, Pankaj; Abril Ferrando, Josep Francesc; Burset Albareda, Moisès; Fickett, James W. (Cold Spring Harbor Laboratory Press-CSHL Press, 2000)
    One of the first useful products from the human genome will be a set of predicted genes. Besides its intrinsic scientific interest, the accuracy and completeness of this data set is of considerable importance for human ...
  • Guigó Serra, Roderic (Institut d'Estudis Catalans, 2000)
  • Valverde, Olga; Maldonado, Rafael; Valjent, Emmanuel; Zimmer, Anne M.; Zimmer, Andreas (Society for Neuroscience, 2000)
    The functional interactions between the endogenous cannabinoid and opioid systems were evaluated in pre-proenkephalin-deficient mice. Antinociception induced in the tail-immersion test by acute Delta9-tetrahydrocannabinol ...
  • Haley, Jane E.; Abogadie, Fe C.; Fernández-Fernández, José Manuel; Dayrell, Mariza; Vallis, Yvonne; Buckley, Noel J.; Brown, David A. (Society for Neuroscience, 2000)
    Rat superior cervical ganglion (SCG) neurons express low-threshold noninactivating M-type potassium channels (I-K(M)), which can be inhibited by activation of M-1 muscarinic receptors (M-1 mAChR) and bradykinin (BK) B-2 ...
  • Thomson, Timothy M.; Lozano, Juan José; Loukili, Noureddine; Carrió, Roberto; Serras Rigalt, Florenci; Cormand, Bru; Valeri, Marta; Díaz, Víctor M.; Abril Ferrando, Josep Francesc; Burset Albareda, Moisès; Merino, Jesús; Macaya, Alfons; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2000)
    UEV proteins are enzymatically inactive variants of the E2 ubiquitin-conjugating enzymes that regulate noncanonical elongation of ubiquitin chains. In Saccharomyces cerevisiae, UEV is part of the RAD6-mediated error-free ...
  • Wiehe, Thomas; Gebauer-Jung, Steffi; Mitchell-Olds, Thomas; Guigó Serra, Roderic (Cold Spring Harbor Laboratory Press-CSHL Press, 2001)
    Conventional methods of gene prediction rely on the recognition of DNA-sequence signals, the coding potential or the comparison of a genomic sequence with a cDNA, EST, or protein database. Reasons for limited accuracy in ...
  • Otto, Christiane; Kovalchuk, Yury; Wolfer, David Paul; Gass, Peter; Martin, Miguel; Zuschratter, Werner; Gröne, Hermann Josef; Kellendonk, Christoph; Tronche, François; Maldonado, Rafael; Lipp, Hans-Peter; Konnerth, Arthur; Schütz, Günter (Society for Neuroscience, 2001)
    The pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor (PAC1) is a G-protein-coupled receptor binding the strongly conserved neuropeptide PACAP with 1000-fold higher affinity than the related peptide ...
  • Zimmer, Andreas; Valjent, Emmanuel; König, Monika; Zimmer, Anne M.; Robledo, M. Patricia; Hahn, Heidi; Valverde, Olga; Maldonado, Rafael (Society for Neuroscience, 2001)
    The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show ...
  • Kalaydjieva, Luba; Gresham, David; Calafell i Majó, Francesc (BioMed Central, 2001)
    Background: Data provided by the social sciences as well as genetic research suggest that the 8-10 million Roma (Gypsies) who live in Europe today are best described as a conglomerate of genetically isolated founder ...
  • Muñoz López, Francisco José; Opazo, Carlos; Gil Gómez, Gabriel; Tapia, Gladys; Fernández, Virginia; Valverde, M. A. (Miguel Ángel); Inestrosa, Nibaldo C. (Society for Neuroscience, 2002)
    Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...
  • Ghozland, Sandy; Matthes, Hans W. D.; Simonin, Frederic; Filliol, Dominique; Kieffer, Brigitte L.; Maldonado, Rafael (Society for Neuroscience, 2002)
    Repeated THC administration produces motivational and somatic adaptive changes leading to dependence in rodents. To investigate the molecular basis for cannabinoid dependence and its possible relationship with the ...

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