Inici
→
Recerca: articles, congressos, llibres
→
Departament de Medicina i Ciències de la Vida
→
Visualitza Departament de Medicina i Ciències de la Vida per matèria

Visualitza Departament de Medicina i Ciències de la Vida per matèria "Parkinson's disease"

Ara mostrant els elements 1-6 de 6

Can digital mobility assessment enhance the clinical assessment of disease severity in Parkinson's disease?

Kirk, Cameron; Rehman, Rana Zia Ur; Galna, Brook; Alcock, Lisa; Ranciati, Saverio; Palmerini, Luca; García Aymerich, Judith; Hansen, Clint; Schaeffer, Eva; Berg, Daniela; Maetzler, Walter; Rochester, Lynn; Del Din, Silvia; Yarnall, Alison J. (IOS Press, 2023)

Background: Real-world walking speed (RWS) measured using wearable devices has the potential to complement the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS III) for motor assessment in ...
Detection of genomic rearrangements from targeted resequencing data in Parkinson's disease patients

Spataro, Nino, 1984-; Roca-Umbert Würth, Ana; Cervera-Carles, Laura; Vallès, Mònica; Anglada Busquets, Roger; Pagonabarraga, Javier; Pascual Sedano, Berta; Campolongo Perillo, Antònia; Kulisevsky, Jaime J.; Casals López, Ferran; Clarimón Echevarría, Jordi; Bosch Fusté, Elena (Wiley, 2017)

Background: The analysis of coverage depth in next-generation sequencing data allows the detection of gene dose alterations. We explore the frequency of such structural events in a Spanish cohort of sporadic PD cases. ...
Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

Pacheco, Carla R.; Morales, Camila N.; Ramírez, Alejandra E.; Muñoz López, Francisco José, 1964-; Gallegos, Scarlet S.; Caviedes, Pablo A.; Aguayo, Luis G.; Opazo, Carlos M. (Wiley, 2015)

It has been postulated that the accumulation of extracellular α-synuclein (α-syn) might alter the neuronal membrane by formation of 'pore-like structures' that will lead to alterations in ionic homeostasis. However, this ...
Functional Rescue of Dopaminergic Neuron Loss in Parkinson's Disease Mice After Transplantation of Hematopoietic Stem and Progenitor Cells

Altarche-Xifro, Wassim; Di Vicino, Umberto; Muñoz-Martin, Maria Isabel; Bortolozzi, Analía; Bové, Jordi; Vila, Miquel; Cosma, Maria Pia (Elsevier, 2016)

Parkinson's disease is a common neurodegenerative disorder, which is due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and for which no definitive cure is currently available. Cellular ...
The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism

González-Aparicio, Ramiro; Blanco, Eduardo; Serrano, Antonia; Pavón, Francisco Javier; Parsons, Loren H.; Maldonado, Rafael, 1961-; Robledo, Patricia, 1958-; Fernández-Espejo, Emilio; Rodríguez de Fonseca, Fernando (Oxford University Press, 2014)

Oleoylethanolamide (OEA) is an agonist of the peroxisome proliferator-activated receptor α (PPARα) and has been described to exhibit neuroprotective properties when administered locally in animal models of several neurological ...
Transcriptome analysis in LRRK2 and idiopathic Parkinson's disease at different glucose levels

Fernández-Santiago, Ruben; Esteve-Codina, Anna; Fernández, Manel; Valldeoriola, Francesc; Sanchez-Gómez, Almudena; Muñoz, Esteban; Compta, Yaroslau; Tolosa, Eduard; Ezquerra, Mario; Martí, Maria José (Nature Research, 2021)

Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson's disease (PD). To detect potential effects of different glucose levels on gene expression, by ...