Browsing Departament de Ciències Experimentals i de la Salut by Subject "ADN"

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Browsing Departament de Ciències Experimentals i de la Salut by Subject "ADN"

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  • Guigó Serra, Roderic; Manichanh, Chaysavanh; Chapple, Charles E.; Frangeul, Lionel; Gloux, Karine; Dore, Joel (Oxford University Press, 2008)
    The construction of metagenomic libraries has permitted the study of microorganisms resistant to isolation and the analysis of 16S rDNA sequences has been used for over two decades to examine bacterial biodiversity. Here, ...
  • Pedersen, Marie; Sunyer Deu, Jordi; Mendez, Michelle A.; Espinosa, Aina; Agramunt, Silvia; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2013)
    Background: Tobacco-smoke, airborne, and dietary exposures to polycyclic aromatic hydrocarbons (PAHs) have been associated with reduced prenatal growth. Evidence from biomarker-based studies of low-exposed populations is ...
  • Cirillo, Davide; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Oxford University Press, 2015)
    Access to genome-wide data provides the opportunity to address questions concerning the ability of transcription factors (TFs) to assemble in distinct macromolecular complexes. Here, we introduce the PAnDA (Protein And DNA ...
  • Serra Juhé, Clara, 1984-; Rodríguez Santiago, Benjamín; Cuscó, Ivon; Vendrell, Teresa; Camats, Núria; Torán, Núria; Pérez Jurado, Luis Alberto (Public Library of Science (PLoS), 2012)
    Background: Congenital malformations are present in approximately 2–3% of liveborn babies and 20% of stillborn fetuses. The mechanisms underlying the majority of sporadic and isolated congenital malformations are poorly ...
  • Gazave, Elodie; Darre, Fleur; Morcillo Suárez, Carlos; Petit, Natalia; Carreño, Angel; Marigorta, Urko M.; Ryder, Oliver A.; Blancher, Antoine; Rocchi, Mariano; Bosch Fusté, Elena; Baker, Carl; Marquès i Bonet, Tomàs, 1975-; Eichler, Evan E.; Navarro i Cuartiellas, Arcadi, 1969- (Cold Spring Harbor Laboratory Press (CSHL Press), 2011)
    Copy number variants (CNVs) are increasingly acknowledged as an important source of evolutionary novelties in the human lineage. However, our understanding of their significance is still hindered by the lack of primate CNV ...
  • Duch, Alba; Nadal Clanchet, Eulàlia de; Posas Garriga, Francesc (Elsevier, 2013)
    Transcription during S phase needs to be spatially and temporally regulated to prevent collisions between the transcription and replication machineries. Cells have evolved a number of mechanisms to make both processes ...
  • Giannuzzi, Giuliana; Siswara, Priscillia; Malig, Maika; Marquès i Bonet, Tomàs, 1975-; Mullikin, James C.; Ventura, Mario; Eichler, Evan E.; NISC Comparative Sequencing Program (Cold Spring Harbor Laboratory Press (CSHL Press), 2013)
    Core duplicons in the human genome represent ancestral duplication modules shared by the majority of intrachromosomal duplication blocks within a given chromosome. These cores are associated with the emergence of novel ...
  • González Neira, Anna; Calafell i Majó, Francesc; Navarro i Cuartiellas, Arcadi, 1969-; Lao Grueso, Oscar, 1976-; Cann, Howard M.; Comas, David, 1969-; Bertranpetit, Jaume, 1952- (BioMed Central, 2004)
    Recent studies of haplotype diversity in a number of genomic regions have suggested that long stretches of DNA are preserved in the same chromosome, with little evidence of recombination events. The knowledge of the extent ...
  • Ballana Guix, Ester; Mercader Bigas, Josep Maria; Fischel Ghodsian, Nathan; Estivill, Xavier, 1955- (BioMed Central, 2007)
    Background: Mitochondrial DNA (mtDNA) mutations account for at least 5% of cases of postlingual, nonsyndromic hearing impairment. Among them, mutation A1555G is frequently found associated with aminoglycoside-induced and/or ...
  • Gazave, Elodie; Marquès i Bonet, Tomàs, 1975-; Fernando, Olga; Charlesworth, Brian; Navarro i Cuartiellas, Arcadi, 1969- (BioMed Central, 2007)
    We present the first analysis of human-chimpanzee intron divergence, in which differences in the number of substitutions per intronic site (Ki) can be interpreted as the footprint of different intensities and directions ...
  • Meyerhans, Andreas; Suspène, Rodolphe (Public Library of Science (PLoS), 2012)
    In the nucleus of HIV-1 infected cells, unintegrated HIV-1 DNA molecules exist in the form of one and two LTR circles and linear molecules with degraded extremities. In tissue culture they are invariably more numerous than ...
  • Alves-Rodrigues, Isabel; Ferreira, Pedro G.; Moldón Vara, Alberto; Vivancos Prellezo, Ana; Hidalgo Hernando, Elena; Guigó Serra, Roderic; Ayté del Olmo, José (Elsevier, 2016)
    Meiosis is a differentiated program of the cell cycle that is characterized by high levels of recombination followed by two nuclear divisions. In fission yeast, the genetic program during meiosis is regulated at multiple ...
  • Vives, Sergi; Gilbert, M Thomas; Arenas, Conxita; Gigli, Elena, 1978-; Lao Grueso, Oscar, 1976-; Lalueza Fox, Carles, 1965- (BioMed Central, 2008)
    Background: We have analysed the distribution of post mortem DNA damage derived miscoding lesions from the datasets of seven published Neandertal specimens that have extensive cloned sequence coverage over the mitochondrial ...
  • Sonay, Tugce Bilgin; Carvalho, Tiago; Robinson, Mark D.; Greminger, Maja P.; Krützen, Michael; Comas, David, 1969-; Highnam, Gareth; Mittelman, David; Sharp, Andrew J.; Marquès i Bonet, Tomàs, 1975-; Wagner, Andreas (Cold Spring Harbor Laboratory Press (CSHL Press), 2015)
    Tandem repeats (TRs) are stretches of DNA that are highly variable in length and mutate rapidly. They are thus an important source of genetic variation. This variation is highly informative for population and conservation ...
  • Ivanova, Tsvetomira Georgieva, 1978-; Alves-Rodrigues, Isabel; Gómez Escoda, Blanca; Dutta, Chaitali; DeCaprio, James A.; Rhind, Nick; Hidalgo Hernando, Elena; Ayté del Olmo, José (American Society for Cell Biology, 2013)
    In fission yeast cells, Cds1 is the effector kinase of the DNA replication checkpoint. We previously showed that when the DNA replication checkpoint is activated, the repressor Yox1 is phosphorylated and inactivated by ...
  • Marquès i Bonet, Tomàs, 1975-; Cheng, Ze; She, Xinwei; Eichler, Evan E.; Navarro i Cuartiellas, Arcadi, 1969- (BioMed Central, 2008)
    Background: It has been suggested that chromosomal rearrangements harbor the molecular footprint of the biological phenomena which they induce, in the form, for instance, of changes in the sequence divergence rates of ...
  • Hernando Herráez, Irene; Heyn, Holger; Fernández Callejo, Marcos; Vidal, Enrique; Fernandez Bellon, Hugo; Prado Martínez, Javier, 1987-; Sharp, Andrew J.; Esteller, Manel; Marquès i Bonet, Tomàs, 1975- (Oxford University Press, 2015)
    Despite the increasing knowledge about DNA methylation, the understanding of human epigenome evolution is in its infancy. Using whole genome bisulfite sequencing we identified hundreds of differentially methylated regions ...
  • Nikolaou, Christoforos; Bermúdez, Ignacio; Manichanh, Chaysavanh; García Martínez, José; Guigó Serra, Roderic; Pérez Ortín, José E.; Roca, Joaquim (Oxford University Press, 2013)
    Eukaryotic topoisomerase II (topo II) is the essential decatenase of newly replicated chromosomes and the main relaxase of nucleosomal DNA. Apart from these general tasks, topo II participates in more specialized functions. ...
  • Coll Lladó, Montserrat; Acinas, Silvia G; Pujades Corbi, Cristina; Pedrós-Alió, Carles (Public Library of Science (PLoS), 2011)
    Microbial transcriptomics are providing new insights into the functional processes of microbial communities. However, analysis of each sample is still expensive and time consuming. A rapid and low cost method that would ...

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