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Exploring the role of DYRK1A in RNA polymerase III transcription : DYRK1A as a potential regulator of TFIIIC

Cort, Rianne Angelica (Universitat Pompeu Fabra, 2020-01-14)

The kinase DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a dosage-sensitive gene, since both haploinsufficiency and overexpression when in trisomy lead to pathological phenotypes in humans. In this Thesis, the ...
Nuclear DYRK1A :new insights into its role within the nucleus

Di Vona, Chiara (Universitat Pompeu Fabra, 2014-10-31)

The view on how protein kinases regulate gene expression have recently expanded to include not only transcription factors but also histones, chromatin remodelers or components of the basal transcription machinery, which ...
Polyhistidine repeats and Dyrk 1a: from the localization on the function

Salichs Fradera, Eulàlia (Universitat Pompeu Fabra, 2011-04-12)

PolyHistidine repeats and DYRK1A: from the localization to the function<br/>El principal objectiu d'aquesta tesi ha estat el d'esbrinar noves funcions de la proteína quinasa DYRK1A en el nucli cel.lular. Donat que el domini ...
RNF169 and RNF168 novel substrates of DYRK1A : connecting DYRK1A to DNA-damage repair

Roewenstrunk, Julia Maria (Universitat Pompeu Fabra, 2018-05-18)

Gene dosage alterations of the kinase DYRK1A are linked to disease in humans. To better understand DYRK1A activities an interactome analysis was performed. RNF169, an E3-ubiquitin ligase key component of the cellular ...
Role of DYRK1A in the development of the cerebral cortex : Implication in Down Syndrome

Najas Sales, Sònia (Universitat Pompeu Fabra, 2016-05-11)

In this work we have assessed the possible contribution of the human chromosome-21 gene DYRK1A in the developmental cortical alterations associated with Down Syndrome using the mBACTgDyrk1a mouse, which carries 3 copies ...