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Visualitza TDX per autoria "Aramburu, José (Aramburu Beltrán)"

Ara mostrant els elements 1-11 de 11

Analysis of transcription mechanisms that limit type I interferon responses

Huerga Encabo, Hector (Universitat Pompeu Fabra, 2019-03-01)

Programa de doctorat en Biomedicina
Caracterización funcional de mecanismos que regulan el factor de transcripción NFAT5

Minguillón Pedreño, Jordi (Universitat Pompeu Fabra, 2012-03-02)

El NFAT5 es un factor de transcripción de la familia Rel, la cual incluye a los NFATc y los NF-[kappa]B. Hasta ahora, el NFAT5 había sido caracterizado principalmente como un factor de respuesta a estrés osmótico ya que ...
Circadian regulation of macrophages in homeostasis and disease

Val Casals, Maria (Universitat Pompeu Fabra, 2020-09-15)

Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària circadiana consisteix ...
Influence of metabolism in the regulation of T cell differentiation

Tejedor Vaquero, Sonia (Universitat Pompeu Fabra, 2019-01-08)

Glucose is a key nutrient for T cells. Despite that T cell activation is impaired when they are deprived of glucose, it has also been shown that T effector responses can be elicited in vivo in glucose-poor environments, ...
New insights into transcription that preserve hematopoietic stem cell homeostasis

Traveset Martínez, Laia (Universitat Pompeu Fabra, 2020-12-09)

Maintenance of steady-state and stress-adapted hematopoiesis depends on the fitness of hematopoietic stem and progenitor cells (HSPCs) in the bone marrow. Hematopoietic stem cells (HSCs) can adapt to stress by expanding ...
Novel transcription regulators of tissue macrophages and alternative macrophage polarization

Higuera González, Laura (2021-10-29)

Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network of transcription ...
Regulation of NFAT5 by signaling pathways involved in osmotic stress responses and cell growth

Morancho Armisen, Beatriz (Universitat Pompeu Fabra, 2012-03-02)

NFAT5 is the main regulator of an osmoprotective gene program that is switched on by osmotic stress. Hypertonicity causes a harmful increase in the intracellular concentration of inorganic ions and NFAT5-regulated genes ...
Regulation of T cell fates by the transcription factor NFAT5 in different microenvironments

Alberdi Ibarzabal, Maria (Universitat Pompeu Fabra, 2018-04-12)

CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...
Regulatory role of the mechanistic target of Rapamycin (mTOR) on the expression of osmotic stress response genes in mammalian cells

Ortells Campos, Mª Carmen (Universitat Pompeu Fabra, 2012-11-06)

Adaptive responses allow cells to maintain their growth as well as their proliferative potential under diverse stress conditions. It is known that, growth and proliferation can be suppressed by intense stress, but maintained ...
Role of the transcription factor NFAT5 in mammalian cell cycle regulation

Drews-Elger, Katherine (Universitat Pompeu Fabra, 2011-04-12)

The transcription factor NFAT5/TonEBP belongs to the Rel family, which also comprises NF ÛB and NFATc proteins. NFAT5 only shares structural and functional homology with other Rel family members at the level of the DNA ...
The role of CDKN1B-p27kip1 deregulation in the pathogenesis of pediatric T-cell acute lymphoblastic leukemia

Colomer-Lahiguera, Sara (Universitat Pompeu Fabra, 2018-05-02)

T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10 15% of pediatric ALL. The oncogenic transformation of T-cell precursors is driven by a broad spectrum of genetic abnormalities. We have confirmed the high frequency ...