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Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes

Sala, David; Ivanova, Saska; Plana, Natàlia; Ribas, Vicent; Duran, Jordi; Bach, Daniel; Turkseven, Saadet; Laville, Martine; Vidal, Hubert; Karczewska-Kupczewska, Monika; Kowalska, Irina; Straczkowski, Marek; Testar, Xavier; Palacín Mateo, Manuel; Sandri, Marco; Serrano, Antonio L.; Zorzano, Antonio (American Society for Clinical Investigation, 2014)

A precise balance between protein degradation and synthesis is essential to preserve skeletal muscle mass. Here, we found that TP53INP2, a homolog of the Drosophila melanogaster DOR protein that regulates autophagy in ...